RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis.

RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis.

Mammalian RAD52 is a DNA repair factor with strand annealing and recombination mediator activities that appear important in both interphase and mitotic cells. Nonetheless, RAD52 is dispensable for cell viability. To query RAD52 synthetic lethal relationships, we performed genome-wide CRISPR knock-ou...

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Bibliographic Details
Main Authors: Beth Osia, Arianna Merkell, Felicia Wednesday Lopezcolorado, Xiaoli Ping, Jeremy M Stark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011479&type=printable
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