Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy

Mitigating cardiac allograft vasculopathy in a murine model via CD40-TRAF6 blockade and cyclosporin A synergy

Abstract The interactions between CD40 and tumor necrosis factor receptor-associated factor 6 (TRAF6) are implicated in chronic inflammation and fibrosis. Given their poorly understood role in chronic transplant rejection, our study focused on investigating the CD40-TRAF6 interactions in murine mode...

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Bibliographic Details
Main Authors: Yajun Huang, Junlin Lai, Xing Chen, Jinfeng Yang, Chenghao Li, Yixuan Wang, Yuqi Chen, Tian Xia, Yijie Luo, Wai Yen Yim, Xiangchao Ding, Guohua Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Heart transplantation
Cardiac allograft vasculopathy
TRAF6
Online Access:https://doi.org/10.1038/s41598-025-08315-5
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