Total Thrombus-Formation System in Patients with Peripheral Artery Disease
The Total Thrombus-formation Analysis System (T-TAS) is an automated device using coated microchips to assess thrombus formation under flow conditions. Its value to monitor coagulation function in patients under antiplatelet therapy awaits further clarification. This study evaluated T-TAS to detect...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-11-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241301412 |
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| author | Christian Pfrepper MD Careen Franke MD Michael Metze MD Maria Weise MD Annelie Siegemund PhD Roland Siegemund PhD Martin Federbusch MD Reinhard Henschler MD Sirak Petros MD Manuela Konert MD |
| author_facet | Christian Pfrepper MD Careen Franke MD Michael Metze MD Maria Weise MD Annelie Siegemund PhD Roland Siegemund PhD Martin Federbusch MD Reinhard Henschler MD Sirak Petros MD Manuela Konert MD |
| author_sort | Christian Pfrepper MD |
| collection | DOAJ |
| description | The Total Thrombus-formation Analysis System (T-TAS) is an automated device using coated microchips to assess thrombus formation under flow conditions. Its value to monitor coagulation function in patients under antiplatelet therapy awaits further clarification. This study evaluated T-TAS to detect response to dual antiplatelet therapy (DAPT) in patients with peripheral artery disease (PAD). T-TAS using the platelet-chip (PL-chip) and atheroma-chip (AR-chip) was performed in 60 patients with PAD on the day after lower extremity revascularization. Results were compared with light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA, ADP- and ASPI-test). To determine T-TAS reference ranges, 30 healthy blood donors were enrolled. The area under the curve of the PL-chip (AUC-PL) was outside the reference range in 91.2% and AUC-AR in 21.1% of the PAD patients. Low responders in MEA ASPI, MEA ADP or both tests and low responders in LTA induced by ADP had a significantly higher AUC-PL compared to responders (204 vs 70, p = .016 and 140 vs 32, p < .001), respectively. Median AUC-PL in low responders in LTA and MEA, LTA or MEA and in responders in LTA and MEA was 301, 104 and 32 (p = .001), respectively. Our results suggest that the PL-chip can continuously assess the level of response to DAPT and might be helpful to monitor PAD patients. |
| format | Article |
| id | doaj-art-e2e81f5887f14b8fa94a3733e0194ed6 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-e2e81f5887f14b8fa94a3733e0194ed62024-11-22T09:03:38ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232024-11-013010.1177/10760296241301412Total Thrombus-Formation System in Patients with Peripheral Artery DiseaseChristian Pfrepper MD0Careen Franke MD1Michael Metze MD2Maria Weise MD3Annelie Siegemund PhD4Roland Siegemund PhD5Martin Federbusch MD6Reinhard Henschler MD7Sirak Petros MD8Manuela Konert MD9 Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany Department of Cardiology, University of Leipzig Medical Center, Leipzig, Germany Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany Medical ICU, University of Leipzig Medical Center, Leipzig, Germany Medical ICU, University of Leipzig Medical Center, Leipzig, Germany Institute for Laboratory Medicine, University of Leipzig Medical Center, Leipzig, Germany Institute for Transfusion Medicine, University of Leipzig Medical Center, Leipzig, Germany Medical ICU, University of Leipzig Medical Center, Leipzig, Germany Division of Angiology, , Wiesbaden, GermanyThe Total Thrombus-formation Analysis System (T-TAS) is an automated device using coated microchips to assess thrombus formation under flow conditions. Its value to monitor coagulation function in patients under antiplatelet therapy awaits further clarification. This study evaluated T-TAS to detect response to dual antiplatelet therapy (DAPT) in patients with peripheral artery disease (PAD). T-TAS using the platelet-chip (PL-chip) and atheroma-chip (AR-chip) was performed in 60 patients with PAD on the day after lower extremity revascularization. Results were compared with light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA, ADP- and ASPI-test). To determine T-TAS reference ranges, 30 healthy blood donors were enrolled. The area under the curve of the PL-chip (AUC-PL) was outside the reference range in 91.2% and AUC-AR in 21.1% of the PAD patients. Low responders in MEA ASPI, MEA ADP or both tests and low responders in LTA induced by ADP had a significantly higher AUC-PL compared to responders (204 vs 70, p = .016 and 140 vs 32, p < .001), respectively. Median AUC-PL in low responders in LTA and MEA, LTA or MEA and in responders in LTA and MEA was 301, 104 and 32 (p = .001), respectively. Our results suggest that the PL-chip can continuously assess the level of response to DAPT and might be helpful to monitor PAD patients.https://doi.org/10.1177/10760296241301412 |
| spellingShingle | Christian Pfrepper MD Careen Franke MD Michael Metze MD Maria Weise MD Annelie Siegemund PhD Roland Siegemund PhD Martin Federbusch MD Reinhard Henschler MD Sirak Petros MD Manuela Konert MD Total Thrombus-Formation System in Patients with Peripheral Artery Disease Clinical and Applied Thrombosis/Hemostasis |
| title | Total Thrombus-Formation System
in Patients with Peripheral Artery Disease |
| title_full | Total Thrombus-Formation System
in Patients with Peripheral Artery Disease |
| title_fullStr | Total Thrombus-Formation System
in Patients with Peripheral Artery Disease |
| title_full_unstemmed | Total Thrombus-Formation System
in Patients with Peripheral Artery Disease |
| title_short | Total Thrombus-Formation System
in Patients with Peripheral Artery Disease |
| title_sort | total thrombus formation system in patients with peripheral artery disease |
| url | https://doi.org/10.1177/10760296241301412 |
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