PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA
Cerebrovascular accident (CVA) is a common devastating neurological complication of sickle cell disorder (SCD) with a high recurrent and mortality rate. The Stroke Prevention Trial in Sickle Cell Anaemia study (STOP) recommends routine screening with transcranial Doppler ultrasonography in children...
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| Language: | English |
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PAGEPress Publications
2017-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2950 |
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| author | Motunrayo Oluwabukola Adekunle |
| author_facet | Motunrayo Oluwabukola Adekunle |
| author_sort | Motunrayo Oluwabukola Adekunle |
| collection | DOAJ |
| description | Cerebrovascular accident (CVA) is a common devastating neurological complication of sickle cell disorder (SCD) with a high recurrent and mortality rate. The Stroke Prevention Trial in Sickle Cell Anaemia study (STOP) recommends routine screening with transcranial Doppler ultrasonography in children aged two to sixteen years with SCD. The present study assessed cerebral blood flow velocities of children with SCD in accordance with the recommendation of routine screening by the STOP study.
Methods: Transcranial Doppler ultrasonography was done for children with SCD that attended Sickle Cell Foundation, Nigeria between July and November 2015.
Results: In all, 388 subjects were screened within the study period (360 HbSS and 28 HbSC). The prevalence of abnormal Time-Averaged Maximum Mean Velocity (TAMMV) of at least 200cm/second was 10.8%: this was seen solely in HbSS subjects. The mean Time-averaged mean of the maximum (TAMM) velocity were 163 ± 25cm/sec, 162±30cm/sec and 150 ± 30cm/sec for children less than five years, five to ten years and eleven to sixteen years respectively.
Conclusion: The prevalence of abnormal TAMM velocity is high in children with HbSS. The need for availability of and accessibility to transcranial Doppler screening is emphasized. |
| format | Article |
| id | doaj-art-e2d6ee749bc54741b4ebf1b3fd4b2397 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-e2d6ee749bc54741b4ebf1b3fd4b23972024-12-02T09:47:37ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062017-08-0191e2017050e201705010.4084/mjhid.2017.0501703PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIAMotunrayo Oluwabukola Adekunle0Lagos State University Teaching Hospital, Ikeja Lagos State, Nigeria West AfricaCerebrovascular accident (CVA) is a common devastating neurological complication of sickle cell disorder (SCD) with a high recurrent and mortality rate. The Stroke Prevention Trial in Sickle Cell Anaemia study (STOP) recommends routine screening with transcranial Doppler ultrasonography in children aged two to sixteen years with SCD. The present study assessed cerebral blood flow velocities of children with SCD in accordance with the recommendation of routine screening by the STOP study. Methods: Transcranial Doppler ultrasonography was done for children with SCD that attended Sickle Cell Foundation, Nigeria between July and November 2015. Results: In all, 388 subjects were screened within the study period (360 HbSS and 28 HbSC). The prevalence of abnormal Time-Averaged Maximum Mean Velocity (TAMMV) of at least 200cm/second was 10.8%: this was seen solely in HbSS subjects. The mean Time-averaged mean of the maximum (TAMM) velocity were 163 ± 25cm/sec, 162±30cm/sec and 150 ± 30cm/sec for children less than five years, five to ten years and eleven to sixteen years respectively. Conclusion: The prevalence of abnormal TAMM velocity is high in children with HbSS. The need for availability of and accessibility to transcranial Doppler screening is emphasized.http://www.mjhid.org/index.php/mjhid/article/view/2950Transcranial Doppler Ultrasonography, Cerebrovascular Accident |
| spellingShingle | Motunrayo Oluwabukola Adekunle PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA Mediterranean Journal of Hematology and Infectious Diseases Transcranial Doppler Ultrasonography, Cerebrovascular Accident |
| title | PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA |
| title_full | PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA |
| title_fullStr | PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA |
| title_full_unstemmed | PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA |
| title_short | PATTERN OF CEREBRAL BLOOD FLOW VELOCITY USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY IN CHILDREN WITH SICKLE CELL DISORDER IN LAGOS STATE, NIGERIA |
| title_sort | pattern of cerebral blood flow velocity using transcranial doppler ultrasonography in children with sickle cell disorder in lagos state nigeria |
| topic | Transcranial Doppler Ultrasonography, Cerebrovascular Accident |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2950 |
| work_keys_str_mv | AT motunrayooluwabukolaadekunle patternofcerebralbloodflowvelocityusingtranscranialdopplerultrasonographyinchildrenwithsicklecelldisorderinlagosstatenigeria |