A whole blood assay for antibody dependent phagocytosis of Plasmodium falciparum infected erythrocytes

A whole blood assay for antibody dependent phagocytosis of Plasmodium falciparum infected erythrocytes

Abstract Background Antibodies are used to protect against Plasmodium falciparum malaria. One antibody target, the variant surface antigens, is expressed on infected erythrocytes (IEs). Antibodies to these antigens can either block IE sequestration in the tissues, facilitate natural killer cell-medi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dilini Rathnayake, Wina Hasang, Alexander Macpherson, HongHua Ding, Laurens Manning, Moses Laman, Maria Ome-Kaius, Holger W. Unger, Feiko Ter Kuile, Mwayi Madanitsa, Bruce Wines, P. Mark Hogarth, Elizabeth H. Aitken, Stephen J. Rogerson
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Series:	Communications Medicine
Online Access:	https://doi.org/10.1038/s43856-025-00989-2
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Roles of the phagocytosis checkpoint in radiotherapy
by: Yulan Kui, et al.
Published: (2025-08-01)

Quantitative modeling of rod outer segment phagocytosis and recycling
by: Christina Kiel, et al.
Published: (2025-07-01)

Consequences of internalization and phagocytosis of Listeria during an infectious process
by: Yu. N. Odintsov, et al.
Published: (2003-12-01)

Autophagy and LC3-associated phagocytosis: similarities and differences
by: B. R. Ibragimov, et al.
Published: (2023-04-01)

Women's access and provider practices for the case management of malaria during pregnancy: a systematic review and meta-analysis.
by: Jenny Hill, et al.
Published: (2014-08-01)

Impact of Hyperbaric Oxygenation on the Phagocytosis-Stimulating Function of the Operated Liver
by: P. N. Savilov
Published: (2008-10-01)

The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells
by: Teresa Garcia-Aguilar, et al.
Published: (2016-01-01)

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
by: Lian Zhao, et al.
Published: (2015-07-01)

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques
by: Yulin Liu, et al.
Published: (2025-08-01)

Lipoprotein(a), an Opsonin, Enhances the Phagocytosis of Nontypeable Haemophilus influenzae by Macrophages
by: Zhi Liu, et al.
Published: (2021-01-01)

Regional-specific activation of phagocytosis in the rat brain in the conditions of sepsis-associated encephalopathy
by: T. V. Shulyatnikova, et al.
Published: (2021-02-01)

Factors affecting the delivery, access, and use of interventions to prevent malaria in pregnancy in sub-Saharan Africa: a systematic review and meta-analysis.
by: Jenny Hill, et al.
Published: (2013-01-01)

Sera contributing to mycobacterial growth restriction in vitro display enhanced Fc-mediated phagocytosis
by: Krista E. van Meijgaarden, et al.
Published: (2025-05-01)

Pan-cancer analysis of phagocytosis regulators in female-specific cancers: a focus on HMGB2
by: Xiaoqin Lu, et al.
Published: (2025-05-01)

USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
by: Panpan Dai, et al.
Published: (2025-05-01)

Aerobic Exercise Ameliorates Alzheimer’s Disease-Like Pathology by Regulating Hepatic Phagocytosis of Aβ
by: Qing Wang, et al.
Published: (2025-04-01)

The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.
by: Breanna Walsh, et al.
Published: (2025-07-01)

Surface N- or O-linked glycans on bovine spermatozoa play minimal role in evading macrophage mediated phagocytosis
by: Jatinder Singh Chera, et al.
Published: (2025-03-01)

Misdiagnosis of an imported case of malaria caused by Plasmodium falciparum
by: Waleed Mohammad Hussain, et al.
Published: (2009-03-01)

Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier
by: Kaili Liang, et al.
Published: (2024-12-01)

Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice
by: Xinya Gao, et al.
Published: (2025-07-01)

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress
by: Guan H, et al.
Published: (2025-08-01)

Prevalence and clinical impact of severe anaemia in referral hospitals in southern Benin
by: Landry Assongba, et al.
Published: (2025-07-01)

The immunostimulant effect of jamblang stem bark (Syzygium cumini L.) ethanol extract against mice macrophages phagocytosis activity and capacity
by: WIDYA SARI, et al.
Published: (2025-07-01)

Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
by: Ze-Xi Jia, et al.
Published: (2025-08-01)

Protocol for performing and analyzing a live-cell imaging-based microglia phagocytosis assay using AI on the Olympus ScanR system
by: Alexander Zähringer, et al.
Published: (2025-09-01)

Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis
by: Dong-Dong Li, et al.
Published: (2025-07-01)

Rising prevalence of Plasmodium falciparum Artemisinin partial resistance mutations in Ethiopia
by: Bokretsion G. Brhane, et al.
Published: (2025-07-01)

Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites
by: Collins Ojonugwa Mamudu, et al.
Published: (2024-01-01)

Risk factor for gametocyte carriage and gametocytemia in Plasmodium vivax and Plasmodium falciparum
by: Minxi Li, et al.
Published: (2025-08-01)

Biochemical and biophysical characterization of Plasmodium falciparum glucose regulated protein 170
by: Florence Lisa Muzenda, et al.
Published: (2025-07-01)

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway
by: Jie Li, et al.
Published: (2025-08-01)

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes
by: Sook-Yoong Chia, et al.
Published: (2025-08-01)

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies
by: Opeyemi Ernest Oludada, et al.
Published: (2023-04-01)

Modulation of apoptosis against P. falciparum by low dose radiation in human PBMCs
by: Sompal Singh, et al.
Published: (2009-12-01)

Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia
by: Marc-Antoine Guery, et al.
Published: (2025-05-01)

Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes
by: Danushka Marapana, et al.
Published: (2025-07-01)

Placental Malaria and the Plasmodium falciparum Erythrocyte Membrane Protein (VAR2CSA).
by: Okungbowa, M. A. and Madumere, R. J.
Published: (2018-03-01)

Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection
by: Andrea A. Berry, et al.
Published: (2025-03-01)

Climate therapy and the development of South Africa as a health resort, c.1850–1910
by: Rogerson Christian M., et al.
Published: (2021-06-01)