A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer
The increasing incidence and mortality associated with lung cancer (LC) is a significant global health challenge. The underlying mechanisms contributing to LC remain inadequately understood. However, emerging evidence suggests that the epigenetic modifier protein arginine methyltransferase 5 (PRMT5)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1478672/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846150279948402688 |
|---|---|
| author | Yan Wang Daifang Chu Haichao Li Jiangjiang Fan Ximing Zhu Yulong Ma Zhongping Gu Nianlin Xie Pengyu Jing |
| author_facet | Yan Wang Daifang Chu Haichao Li Jiangjiang Fan Ximing Zhu Yulong Ma Zhongping Gu Nianlin Xie Pengyu Jing |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | The increasing incidence and mortality associated with lung cancer (LC) is a significant global health challenge. The underlying mechanisms contributing to LC remain inadequately understood. However, emerging evidence suggests that the epigenetic modifier protein arginine methyltransferase 5 (PRMT5) plays a complex role in various cellular processes, including DNA repair, gene transcription, and alternative splicing, through its function in catalyzing the symmetric dimethylation of both histone and non-histone proteins. In this study, we examined the functional role of PRMT5 utilizing LC-related datasets (GSE30219, GSE50081, and TCGA LC cohort) through a series of analyses. Our findings revealed that PRMT5 was significantly overexpressed in LC samples compared to normal tissues and was correlated with overall survival and disease-free survival rates. Additionally, PRDM1 was identified as a key protein exhibiting a strong interaction with PRMT5. The prognostic model that integrated PRMT5 with clinical factors demonstrated robust performance in assessing survival outcomes. Elevated levels of PRMT5 were associated with poor prognosis in LC, as evidenced by analyses of the GSE30219, GSE50081, and TCGA-LC datasets. Furthermore, we identified 27 ion channel (IC) genes exhibited a correlation with PRMT5 in lung adenocarcinoma (LUAD), of which 9 genes were identified as statistically significant with KM survival analysis. Strikingly, all of the 9 genes, including LRRC8A, the same as PRMT5, were associated with poor prognosis in LUAD. Our research highlights the potential of PRMT5 as a novel prognostic biomarker and its relationship with IC genes in LC. |
| format | Article |
| id | doaj-art-e2ce08f34d144afc8f95d09322218ca1 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e2ce08f34d144afc8f95d09322218ca12024-11-29T05:10:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14786721478672A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancerYan Wang0Daifang Chu1Haichao Li2Jiangjiang Fan3Ximing Zhu4Yulong Ma5Zhongping Gu6Nianlin Xie7Pengyu Jing8Department of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, Yicheng County People’s Hospital, Linfen, Shanxi, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, ChinaThe increasing incidence and mortality associated with lung cancer (LC) is a significant global health challenge. The underlying mechanisms contributing to LC remain inadequately understood. However, emerging evidence suggests that the epigenetic modifier protein arginine methyltransferase 5 (PRMT5) plays a complex role in various cellular processes, including DNA repair, gene transcription, and alternative splicing, through its function in catalyzing the symmetric dimethylation of both histone and non-histone proteins. In this study, we examined the functional role of PRMT5 utilizing LC-related datasets (GSE30219, GSE50081, and TCGA LC cohort) through a series of analyses. Our findings revealed that PRMT5 was significantly overexpressed in LC samples compared to normal tissues and was correlated with overall survival and disease-free survival rates. Additionally, PRDM1 was identified as a key protein exhibiting a strong interaction with PRMT5. The prognostic model that integrated PRMT5 with clinical factors demonstrated robust performance in assessing survival outcomes. Elevated levels of PRMT5 were associated with poor prognosis in LC, as evidenced by analyses of the GSE30219, GSE50081, and TCGA-LC datasets. Furthermore, we identified 27 ion channel (IC) genes exhibited a correlation with PRMT5 in lung adenocarcinoma (LUAD), of which 9 genes were identified as statistically significant with KM survival analysis. Strikingly, all of the 9 genes, including LRRC8A, the same as PRMT5, were associated with poor prognosis in LUAD. Our research highlights the potential of PRMT5 as a novel prognostic biomarker and its relationship with IC genes in LC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1478672/fulllung cancerPRMT5prognosisepigeneticsion channel genes |
| spellingShingle | Yan Wang Daifang Chu Haichao Li Jiangjiang Fan Ximing Zhu Yulong Ma Zhongping Gu Nianlin Xie Pengyu Jing A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer Frontiers in Oncology lung cancer PRMT5 prognosis epigenetics ion channel genes |
| title | A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer |
| title_full | A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer |
| title_fullStr | A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer |
| title_full_unstemmed | A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer |
| title_short | A comprehensive investigation of PRMT5 in the prognosis and ion channel features of lung cancer |
| title_sort | comprehensive investigation of prmt5 in the prognosis and ion channel features of lung cancer |
| topic | lung cancer PRMT5 prognosis epigenetics ion channel genes |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1478672/full |
| work_keys_str_mv | AT yanwang acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT daifangchu acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT haichaoli acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT jiangjiangfan acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT ximingzhu acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT yulongma acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT zhongpinggu acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT nianlinxie acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT pengyujing acomprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT yanwang comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT daifangchu comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT haichaoli comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT jiangjiangfan comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT ximingzhu comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT yulongma comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT zhongpinggu comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT nianlinxie comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer AT pengyujing comprehensiveinvestigationofprmt5intheprognosisandionchannelfeaturesoflungcancer |