The association between lutein and zeaxanthin intake and multi-level biological aging
ObjectiveThis study investigates the potential association between lutein and zeaxanthin (LZ) intake, particularly lutein, and biological aging. The study aims to explore how LZ intake affects the biological aging progression, particularly in organs like the liver, kidneys, and cardiovascular system...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1618158/full |
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| author | Meiyi Tao Lin Zhang Lin Zhang Caidi Jiang Jia Xiang Jia Xiang Shipeng Chen Shipeng Chen Songwen Tan Songwen Tan Songwen Tan Shengli Sun |
| author_facet | Meiyi Tao Lin Zhang Lin Zhang Caidi Jiang Jia Xiang Jia Xiang Shipeng Chen Shipeng Chen Songwen Tan Songwen Tan Songwen Tan Shengli Sun |
| author_sort | Meiyi Tao |
| collection | DOAJ |
| description | ObjectiveThis study investigates the potential association between lutein and zeaxanthin (LZ) intake, particularly lutein, and biological aging. The study aims to explore how LZ intake affects the biological aging progression, particularly in organs like the liver, kidneys, and cardiovascular system, and explore the potential mechanism of lutein as the main carotenoid mediating this effect.MethodsWe analyzed biological aging using biological age calculations based on data from the NHANES 2007–2015 database. Various adjusted models were used to assess the relationship between LZ intake and aging phenotypes. Transcriptome analysis was conducted to explore the potential mechanisms underlying the anti-aging effects of lutein.ResultsA higher intake of LZ was associated with a slower biological aging rate (P < 0.01), observed in major organs such as the liver and kidneys, as well as the cardiovascular system. LZ intake showed a significant negative correlation with biological aging acceleration (P < 0.05). Enrichment analysis suggested that lutein's anti-aging effects might be mediated through telomere regulation and modulation of aging-related metabolic pathways. Additionally, lutein intake appeared to reduce pro-inflammatory Th1 cell abundance, further suggesting a potential anti-aging effect by suppressing inflammation. Sustained lutein intake also led to a decrease in the expression of aging phenotype-related molecules. However, in the evaluation of linear relationships, excessive lutein intake beyond a certain threshold may not yield additional benefits.ConclusionCombined LZ intake is associated with attenuated multi-level biological aging [OR (95% CI): 0.93 (0.88, 0.93), P = 0.016] and high LZ intake significantly reduce the risk of all-cause death (P < 0.001), with lutein driving systemic effects via telomere regulation and inflammation suppression. These findings highlight lutein's translatable potential for aging interventions and provide insights for dietary strategies in aging health management. |
| format | Article |
| id | doaj-art-e2cdf92efe0c40d9bbe0a92a62c8fe28 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-e2cdf92efe0c40d9bbe0a92a62c8fe282025-08-20T03:59:32ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.16181581618158The association between lutein and zeaxanthin intake and multi-level biological agingMeiyi Tao0Lin Zhang1Lin Zhang2Caidi Jiang3Jia Xiang4Jia Xiang5Shipeng Chen6Shipeng Chen7Songwen Tan8Songwen Tan9Songwen Tan10Shengli Sun11Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University), Changsha, ChinaDepartment of Epidemiology and Preventive Medicine, The School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, AustraliaSuzhou Industrial Park Monash Research Institute of Science and Technology, Suzhou, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaHunan Pilot Free Trade Zone Global Cell Bank, Changsha, ChinaHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, ChinaHunan Pilot Free Trade Zone Global Cell Bank, Changsha, ChinaHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, ChinaSuzhou Industrial Park Monash Research Institute of Science and Technology, Suzhou, ChinaHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, ChinaMonash University-Southeast University Joint Research Institute, Suzhou, ChinaHunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University), Changsha, ChinaObjectiveThis study investigates the potential association between lutein and zeaxanthin (LZ) intake, particularly lutein, and biological aging. The study aims to explore how LZ intake affects the biological aging progression, particularly in organs like the liver, kidneys, and cardiovascular system, and explore the potential mechanism of lutein as the main carotenoid mediating this effect.MethodsWe analyzed biological aging using biological age calculations based on data from the NHANES 2007–2015 database. Various adjusted models were used to assess the relationship between LZ intake and aging phenotypes. Transcriptome analysis was conducted to explore the potential mechanisms underlying the anti-aging effects of lutein.ResultsA higher intake of LZ was associated with a slower biological aging rate (P < 0.01), observed in major organs such as the liver and kidneys, as well as the cardiovascular system. LZ intake showed a significant negative correlation with biological aging acceleration (P < 0.05). Enrichment analysis suggested that lutein's anti-aging effects might be mediated through telomere regulation and modulation of aging-related metabolic pathways. Additionally, lutein intake appeared to reduce pro-inflammatory Th1 cell abundance, further suggesting a potential anti-aging effect by suppressing inflammation. Sustained lutein intake also led to a decrease in the expression of aging phenotype-related molecules. However, in the evaluation of linear relationships, excessive lutein intake beyond a certain threshold may not yield additional benefits.ConclusionCombined LZ intake is associated with attenuated multi-level biological aging [OR (95% CI): 0.93 (0.88, 0.93), P = 0.016] and high LZ intake significantly reduce the risk of all-cause death (P < 0.001), with lutein driving systemic effects via telomere regulation and inflammation suppression. These findings highlight lutein's translatable potential for aging interventions and provide insights for dietary strategies in aging health management.https://www.frontiersin.org/articles/10.3389/fnut.2025.1618158/fullbiological agingluteinzeaxanthincarotenoidNHANES |
| spellingShingle | Meiyi Tao Lin Zhang Lin Zhang Caidi Jiang Jia Xiang Jia Xiang Shipeng Chen Shipeng Chen Songwen Tan Songwen Tan Songwen Tan Shengli Sun The association between lutein and zeaxanthin intake and multi-level biological aging Frontiers in Nutrition biological aging lutein zeaxanthin carotenoid NHANES |
| title | The association between lutein and zeaxanthin intake and multi-level biological aging |
| title_full | The association between lutein and zeaxanthin intake and multi-level biological aging |
| title_fullStr | The association between lutein and zeaxanthin intake and multi-level biological aging |
| title_full_unstemmed | The association between lutein and zeaxanthin intake and multi-level biological aging |
| title_short | The association between lutein and zeaxanthin intake and multi-level biological aging |
| title_sort | association between lutein and zeaxanthin intake and multi level biological aging |
| topic | biological aging lutein zeaxanthin carotenoid NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1618158/full |
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