Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers
Protocatechuic acid (PCA), a major active component found in Eucommia ulmoides Oliver, is involved in regulating oxidative stress and inflammation. Heat stress poses a significant threat to the poultry industry. In this study, we investigated the protective effect of PCA on intestinal homeostasis un...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124010022 |
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| _version_ | 1846123521993867264 |
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| author | Shuaiyong Wang Xin Wang Yu Gao Yuchen Fu Zhaoqing Han Ping Xu Jianli Tang |
| author_facet | Shuaiyong Wang Xin Wang Yu Gao Yuchen Fu Zhaoqing Han Ping Xu Jianli Tang |
| author_sort | Shuaiyong Wang |
| collection | DOAJ |
| description | Protocatechuic acid (PCA), a major active component found in Eucommia ulmoides Oliver, is involved in regulating oxidative stress and inflammation. Heat stress poses a significant threat to the poultry industry. In this study, we investigated the protective effect of PCA on intestinal homeostasis under heat stress. Our results indicated that PCA improved the growth performance of broilers during heat stress. Furthermore, PCA mitigated jejunal damage and attenuated the upregulation of inflammatory mediators, including TNF-α, IL-6, and IL-1β, triggered by heat stress. Concurrently, it restored the activity of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC). Furthermore, PCA maintained the jejunum function by increasing the levels of ZO-1, Claudin-1, and Occludin. Mechanistically, PCA inhibited the activation of TLR4/p38 MAPK and NF-κB pathways, thereby regulating the imbalance in oxidative stress and inflammatory responses caused by heat stress. |
| format | Article |
| id | doaj-art-e2c28360d296449a86f3ebbf8869c7a9 |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-e2c28360d296449a86f3ebbf8869c7a92024-12-14T06:29:13ZengElsevierPoultry Science0032-57912024-12-0110312104424Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilersShuaiyong Wang0Xin Wang1Yu Gao2Yuchen Fu3Zhaoqing Han4Ping Xu5Jianli Tang6College of Agriculture and Forestry Science, Linyi University, Linyi, 276000, ChinaCollege of Agriculture and Forestry Science, Linyi University, Linyi, 276000, ChinaCollege of Animal Science and Technology, Shandong Agricultural University, Taian, 271018, ChinaCollege of Agriculture and Forestry Science, Linyi University, Linyi, 276000, ChinaCollege of Agriculture and Forestry Science, Linyi University, Linyi, 276000, ChinaCollege of Agriculture and Forestry Science, Linyi University, Linyi, 276000, ChinaCollege of Veterinary Medicine, Northwest A&F University, Yangling, 712100, China; Correspongding author.Protocatechuic acid (PCA), a major active component found in Eucommia ulmoides Oliver, is involved in regulating oxidative stress and inflammation. Heat stress poses a significant threat to the poultry industry. In this study, we investigated the protective effect of PCA on intestinal homeostasis under heat stress. Our results indicated that PCA improved the growth performance of broilers during heat stress. Furthermore, PCA mitigated jejunal damage and attenuated the upregulation of inflammatory mediators, including TNF-α, IL-6, and IL-1β, triggered by heat stress. Concurrently, it restored the activity of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC). Furthermore, PCA maintained the jejunum function by increasing the levels of ZO-1, Claudin-1, and Occludin. Mechanistically, PCA inhibited the activation of TLR4/p38 MAPK and NF-κB pathways, thereby regulating the imbalance in oxidative stress and inflammatory responses caused by heat stress.http://www.sciencedirect.com/science/article/pii/S0032579124010022Protocatechuic acidHeat stressAntioxidantInflammationBroiler |
| spellingShingle | Shuaiyong Wang Xin Wang Yu Gao Yuchen Fu Zhaoqing Han Ping Xu Jianli Tang Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers Poultry Science Protocatechuic acid Heat stress Antioxidant Inflammation Broiler |
| title | Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers |
| title_full | Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers |
| title_fullStr | Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers |
| title_full_unstemmed | Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers |
| title_short | Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers |
| title_sort | protocatechuic acid attenuates intestinal inflammation through tlr4 p38 and nf κb pathways in heat stressed broilers |
| topic | Protocatechuic acid Heat stress Antioxidant Inflammation Broiler |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124010022 |
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