Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion
Objective: This study aimed to assess the therapeutic effects of Xueshuantong (XST), a traditional Chinese medicine that has been studied for its protective effects on the cardiovascular system and anti-inflammatory properties, on central retinal vein occlusion (CRVO) in rabbits and rats. Materials...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/wjtcm.wjtcm_84_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526990878801920 |
|---|---|
| author | Qiang Chen Jing Zhang Xin-Yu Liu Kai Xu Hui-Yi Guo Ya-Min Li Yu-Qing Guo Li-Na Liang |
| author_facet | Qiang Chen Jing Zhang Xin-Yu Liu Kai Xu Hui-Yi Guo Ya-Min Li Yu-Qing Guo Li-Na Liang |
| author_sort | Qiang Chen |
| collection | DOAJ |
| description | Objective:
This study aimed to assess the therapeutic effects of Xueshuantong (XST), a traditional Chinese medicine that has been studied for its protective effects on the cardiovascular system and anti-inflammatory properties, on central retinal vein occlusion (CRVO) in rabbits and rats.
Materials and Methods:
CRVO was induced in rabbits and rats by laser photocoagulation. The animals were then treated with different doses of XST or lyophilized XST (L). Color fundus photography, fundus fluorescein angiography, histological examination, TUNEL assay, and immunofluorescence staining were conducted to evaluate the therapeutic effects.
Results:
The study revealed that both XST and lyophilized XST injections exhibited therapeutic effects against CRVO in rabbits and rats. The drugs improved retinal lesions and structure and mitigated apoptosis of retinal cells to varying degrees. Additionally, downregulation of tumor necrosis factor-α and interleukin-6 within the retina was observed in both drug groups.
Conclusions:
The results indicate that XST injection exhibited significant protective effects against experimental CRVO by regulating angiogenesis and inflammation, suggesting its potential as an effective therapeutic strategy for treating CRVO. |
| format | Article |
| id | doaj-art-e2b4a42be436405388ab3143e2b5cafb |
| institution | Kabale University |
| issn | 2311-8571 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj-art-e2b4a42be436405388ab3143e2b5cafb2025-01-16T08:47:19ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712024-12-0110454856010.4103/wjtcm.wjtcm_84_24Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein OcclusionQiang ChenJing ZhangXin-Yu LiuKai XuHui-Yi GuoYa-Min LiYu-Qing GuoLi-Na LiangObjective: This study aimed to assess the therapeutic effects of Xueshuantong (XST), a traditional Chinese medicine that has been studied for its protective effects on the cardiovascular system and anti-inflammatory properties, on central retinal vein occlusion (CRVO) in rabbits and rats. Materials and Methods: CRVO was induced in rabbits and rats by laser photocoagulation. The animals were then treated with different doses of XST or lyophilized XST (L). Color fundus photography, fundus fluorescein angiography, histological examination, TUNEL assay, and immunofluorescence staining were conducted to evaluate the therapeutic effects. Results: The study revealed that both XST and lyophilized XST injections exhibited therapeutic effects against CRVO in rabbits and rats. The drugs improved retinal lesions and structure and mitigated apoptosis of retinal cells to varying degrees. Additionally, downregulation of tumor necrosis factor-α and interleukin-6 within the retina was observed in both drug groups. Conclusions: The results indicate that XST injection exhibited significant protective effects against experimental CRVO by regulating angiogenesis and inflammation, suggesting its potential as an effective therapeutic strategy for treating CRVO.https://journals.lww.com/10.4103/wjtcm.wjtcm_84_24angiogenesiscentral retinal vein occlusioninflammationprotective effectsxueshuantong injection |
| spellingShingle | Qiang Chen Jing Zhang Xin-Yu Liu Kai Xu Hui-Yi Guo Ya-Min Li Yu-Qing Guo Li-Na Liang Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion World Journal of Traditional Chinese Medicine angiogenesis central retinal vein occlusion inflammation protective effects xueshuantong injection |
| title | Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion |
| title_full | Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion |
| title_fullStr | Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion |
| title_full_unstemmed | Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion |
| title_short | Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion |
| title_sort | exploring the protective effects of xueshuantong injection on central retinal vein occlusion |
| topic | angiogenesis central retinal vein occlusion inflammation protective effects xueshuantong injection |
| url | https://journals.lww.com/10.4103/wjtcm.wjtcm_84_24 |
| work_keys_str_mv | AT qiangchen exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT jingzhang exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT xinyuliu exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT kaixu exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT huiyiguo exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT yaminli exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT yuqingguo exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion AT linaliang exploringtheprotectiveeffectsofxueshuantonginjectiononcentralretinalveinocclusion |