Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study
Background: Oral submucous fibrosis (OSMF) is one of the most commonly occurring potentially malignant disorders in India and south East Asian countries where betel chewing is common practice. Iron and ascorbic acid are important agents for collagen synthesis. Aims: The aims of this study were to es...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2012-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2012;volume=33;issue=4;spage=224;epage=226;aulast=Shetty |
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| author | Shishir Ram Shetty Subhas Babu Suchetha Kumari Pushparaja Shetty R Vijay Arvind Karikal |
| author_facet | Shishir Ram Shetty Subhas Babu Suchetha Kumari Pushparaja Shetty R Vijay Arvind Karikal |
| author_sort | Shishir Ram Shetty |
| collection | DOAJ |
| description | Background: Oral submucous fibrosis (OSMF) is one of the most commonly occurring potentially malignant disorders in India and south East Asian countries where betel chewing is common practice. Iron and ascorbic acid are important agents for collagen synthesis. Aims: The aims of this study were to estimate the levels of iron and ascorbic acid in serum and saliva in patients with OSMF and to correlate change in levels of iron and ascorbic acid with the histopathological grading of OSMF. Materials and Methods: The study group comprised of 65 clinically diagnosed and histopathologically confirmed cases of OSMF; 21 age- and sex-matched controls were also enrolled in the study. Serum and salivary ascorbic acid were analyzed by the dintrophenyl hydrazine method whereas serum and salivary iron were analyzed by the dipyridyl method. Results: The serum and salivary ascorbic acid levels consistently decreased with the progression of histopathologiocal grading of OSMF. Serum and salivary iron levels were also decreased in OSMF patients, but this was not significant. Conclusion: Ascorbic acid and iron may have been used for the excessive collagen synthesis occurring during progression of OSMF. Hence, serum and salivary monitoring may play a crucial role in the early diagnosis and prognosis of OSMF. |
| format | Article |
| id | doaj-art-e2aad3ee2171456b9f9b1dbcad2ee63f |
| institution | Kabale University |
| issn | 0971-5851 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
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| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-e2aad3ee2171456b9f9b1dbcad2ee63f2025-08-20T03:48:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512012-01-0133422422610.4103/0971-5851.107087Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological studyShishir Ram ShettySubhas BabuSuchetha KumariPushparaja ShettyR VijayArvind KarikalBackground: Oral submucous fibrosis (OSMF) is one of the most commonly occurring potentially malignant disorders in India and south East Asian countries where betel chewing is common practice. Iron and ascorbic acid are important agents for collagen synthesis. Aims: The aims of this study were to estimate the levels of iron and ascorbic acid in serum and saliva in patients with OSMF and to correlate change in levels of iron and ascorbic acid with the histopathological grading of OSMF. Materials and Methods: The study group comprised of 65 clinically diagnosed and histopathologically confirmed cases of OSMF; 21 age- and sex-matched controls were also enrolled in the study. Serum and salivary ascorbic acid were analyzed by the dintrophenyl hydrazine method whereas serum and salivary iron were analyzed by the dipyridyl method. Results: The serum and salivary ascorbic acid levels consistently decreased with the progression of histopathologiocal grading of OSMF. Serum and salivary iron levels were also decreased in OSMF patients, but this was not significant. Conclusion: Ascorbic acid and iron may have been used for the excessive collagen synthesis occurring during progression of OSMF. Hence, serum and salivary monitoring may play a crucial role in the early diagnosis and prognosis of OSMF.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2012;volume=33;issue=4;spage=224;epage=226;aulast=ShettyAscorbic acidcollagenironoral submucous fibrosissaliva |
| spellingShingle | Shishir Ram Shetty Subhas Babu Suchetha Kumari Pushparaja Shetty R Vijay Arvind Karikal Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study Indian Journal of Medical and Paediatric Oncology Ascorbic acid collagen iron oral submucous fibrosis saliva |
| title | Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study |
| title_full | Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study |
| title_fullStr | Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study |
| title_full_unstemmed | Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study |
| title_short | Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study |
| title_sort | evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients a clinicopathological study |
| topic | Ascorbic acid collagen iron oral submucous fibrosis saliva |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2012;volume=33;issue=4;spage=224;epage=226;aulast=Shetty |
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