Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients
Objective: This study investigates the effects of precision health management combined with dual-energy X-ray absorptiometry (DXA) therapy on bone biomarkers in elderly osteoporotic patients. Methods: 236 elderly patients diagnosed with osteoporosis between May 2020 and November 2021 were enrolled f...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524002882 |
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| author | Zhixing Du Xiaojing Yan Yongjian Liu Yongbin Pei Jin Zhou Lei Zhang Dandan Han Litao Chen |
| author_facet | Zhixing Du Xiaojing Yan Yongjian Liu Yongbin Pei Jin Zhou Lei Zhang Dandan Han Litao Chen |
| author_sort | Zhixing Du |
| collection | DOAJ |
| description | Objective: This study investigates the effects of precision health management combined with dual-energy X-ray absorptiometry (DXA) therapy on bone biomarkers in elderly osteoporotic patients. Methods: 236 elderly patients diagnosed with osteoporosis between May 2020 and November 2021 were enrolled from our hospital. Patients were randomly allocated to either the observation group (n = 118), receiving precision health management alongside DXA therapy, or the control group (n = 118), receiving standard treatment. Clinical data were compared between the two groups. Protein levels of bone formation markers (BSAP, OC) and bone resorption markers (CTX, DPD, TRAP) were analyzed using Western blotting. Bone mineral density (BMD) was measured using DXA at baseline, 12 months, and 24 months. Pain levels were assessed using the Visual Analog Scale (VAS) at the same intervals. Osteoporosis knowledge and self-management confidence were evaluated using respective scales before and after intervention. Results: Baseline characteristics did not significantly differ between groups (P > 0.05). The observation group exhibited decreased BSAP and increased OC and OC protein expressions compared to the control group (P < 0.05). CTX, DPD, and TRAP protein levels were significantly lower in the observation group (P < 0.05). Prior to the intervention, there were no significant variations observed in BMD, as well as VAS, knowledge, and self-efficacy scores between the two groups (P > 0.05). However, over the course of 12 and 24 months, the observation group exhibited significant increases in BMD (P < 0.05). VAS scores were notably lower in the observation group during both follow-up assessments (P < 0.05). Furthermore, knowledge scores were higher in the observation group at 12 and 24 months (P < 0.05), while self-efficacy scores showed significant improvement in the observation group at both follow-up intervals (P < 0.05). Conclusion: Precision health management combined with DXA therapy positively impacts elderly osteoporotic patients by enhancing bone biomarkers, promoting bone growth, and preventing bone loss. This approach leads to increased BMD, reduced fracture risk, improved pain management, and enhanced knowledge and self-management abilities related to osteoporosis. |
| format | Article |
| id | doaj-art-e2a19a0c920a4fa8b96fc039628ea1ea |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-e2a19a0c920a4fa8b96fc039628ea1ea2024-12-02T05:04:37ZengElsevierExperimental Gerontology1873-68152024-12-01198112642Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patientsZhixing Du0Xiaojing Yan1Yongjian Liu2Yongbin Pei3Jin Zhou4Lei Zhang5Dandan Han6Litao Chen7Health Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaHealth Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaHealth Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaCorresponding authors at: No.89 Donggang Road, Yuhua District, Shijiazhuang, Hebei Province 050000, China.; Health Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaHealth Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaHealth Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaHealth Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaCorresponding authors at: No.89 Donggang Road, Yuhua District, Shijiazhuang, Hebei Province 050000, China.; Health Management Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaObjective: This study investigates the effects of precision health management combined with dual-energy X-ray absorptiometry (DXA) therapy on bone biomarkers in elderly osteoporotic patients. Methods: 236 elderly patients diagnosed with osteoporosis between May 2020 and November 2021 were enrolled from our hospital. Patients were randomly allocated to either the observation group (n = 118), receiving precision health management alongside DXA therapy, or the control group (n = 118), receiving standard treatment. Clinical data were compared between the two groups. Protein levels of bone formation markers (BSAP, OC) and bone resorption markers (CTX, DPD, TRAP) were analyzed using Western blotting. Bone mineral density (BMD) was measured using DXA at baseline, 12 months, and 24 months. Pain levels were assessed using the Visual Analog Scale (VAS) at the same intervals. Osteoporosis knowledge and self-management confidence were evaluated using respective scales before and after intervention. Results: Baseline characteristics did not significantly differ between groups (P > 0.05). The observation group exhibited decreased BSAP and increased OC and OC protein expressions compared to the control group (P < 0.05). CTX, DPD, and TRAP protein levels were significantly lower in the observation group (P < 0.05). Prior to the intervention, there were no significant variations observed in BMD, as well as VAS, knowledge, and self-efficacy scores between the two groups (P > 0.05). However, over the course of 12 and 24 months, the observation group exhibited significant increases in BMD (P < 0.05). VAS scores were notably lower in the observation group during both follow-up assessments (P < 0.05). Furthermore, knowledge scores were higher in the observation group at 12 and 24 months (P < 0.05), while self-efficacy scores showed significant improvement in the observation group at both follow-up intervals (P < 0.05). Conclusion: Precision health management combined with DXA therapy positively impacts elderly osteoporotic patients by enhancing bone biomarkers, promoting bone growth, and preventing bone loss. This approach leads to increased BMD, reduced fracture risk, improved pain management, and enhanced knowledge and self-management abilities related to osteoporosis.http://www.sciencedirect.com/science/article/pii/S0531556524002882Precision health managementDual-energy bone density meterSenile osteoporosisBone biomarkers |
| spellingShingle | Zhixing Du Xiaojing Yan Yongjian Liu Yongbin Pei Jin Zhou Lei Zhang Dandan Han Litao Chen Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients Experimental Gerontology Precision health management Dual-energy bone density meter Senile osteoporosis Bone biomarkers |
| title | Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| title_full | Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| title_fullStr | Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| title_full_unstemmed | Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| title_short | Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| title_sort | effects of precision health management combined with dual energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients |
| topic | Precision health management Dual-energy bone density meter Senile osteoporosis Bone biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524002882 |
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