Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application.
<h4>Objective</h4>Using electrochemical characterization methods of stimulation electrodes as well as accelerated stimulation examinations, a safe operating field for stimulation is investigated for particularly very large Pt-Ir macroelectrodes in a Laplace configuration.<h4>Approa...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315779 |
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| author | Elisa Leusmann Ciamak Abkai Michael Tittelbach Wigand Poppendieck |
| author_facet | Elisa Leusmann Ciamak Abkai Michael Tittelbach Wigand Poppendieck |
| author_sort | Elisa Leusmann |
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| description | <h4>Objective</h4>Using electrochemical characterization methods of stimulation electrodes as well as accelerated stimulation examinations, a safe operating field for stimulation is investigated for particularly very large Pt-Ir macroelectrodes in a Laplace configuration.<h4>Approach</h4>Traditional methods such as Electrochemical Impedance Spectroscopy, Cyclic Voltammetry and biphasic, charge balanced current pulses were applied on Pt-Ir macroelectrodes in phosphate buffered saline solution to investigate reversible boundaries. These experiments were adapted to approach realistic working conditions.<h4>Main results</h4>Investigating operational conditions close to realistic use cases have shown an anti-correlation between higher scan rates and the occurrence of irreversible reactions. In addition, at higher current pulse amplitudes (>3 mA), the voltage dropping across the phase boundary (Ema and Emc) saturated. The value of the residual voltage depends on the degree of charge balance of the biphasic pulse. Thus, we have been able to detect more dissolved platinum at high residual voltages-objected by mass spectroscopic measurement.<h4>Significance</h4>Residual voltage plays a greater role concerning reversibility in prolonged stimulation and charge imbalance of applied biphasic current pulses. The Ema saturation is suggested as a new marker for the occurrence of irreversible reactions which needs further investigation. Current amplitudes of 1 mA for the considered single electrode configuration did not lead to a capacitive voltage saturation nor a considerable dissolution of platinum ions and is thus considered as a safe operation configuration. |
| format | Article |
| id | doaj-art-e2943c92f96b4ae6a85a860960e871f2 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-e2943c92f96b4ae6a85a860960e871f22025-01-08T05:32:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031577910.1371/journal.pone.0315779Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application.Elisa LeusmannCiamak AbkaiMichael TittelbachWigand Poppendieck<h4>Objective</h4>Using electrochemical characterization methods of stimulation electrodes as well as accelerated stimulation examinations, a safe operating field for stimulation is investigated for particularly very large Pt-Ir macroelectrodes in a Laplace configuration.<h4>Approach</h4>Traditional methods such as Electrochemical Impedance Spectroscopy, Cyclic Voltammetry and biphasic, charge balanced current pulses were applied on Pt-Ir macroelectrodes in phosphate buffered saline solution to investigate reversible boundaries. These experiments were adapted to approach realistic working conditions.<h4>Main results</h4>Investigating operational conditions close to realistic use cases have shown an anti-correlation between higher scan rates and the occurrence of irreversible reactions. In addition, at higher current pulse amplitudes (>3 mA), the voltage dropping across the phase boundary (Ema and Emc) saturated. The value of the residual voltage depends on the degree of charge balance of the biphasic pulse. Thus, we have been able to detect more dissolved platinum at high residual voltages-objected by mass spectroscopic measurement.<h4>Significance</h4>Residual voltage plays a greater role concerning reversibility in prolonged stimulation and charge imbalance of applied biphasic current pulses. The Ema saturation is suggested as a new marker for the occurrence of irreversible reactions which needs further investigation. Current amplitudes of 1 mA for the considered single electrode configuration did not lead to a capacitive voltage saturation nor a considerable dissolution of platinum ions and is thus considered as a safe operation configuration.https://doi.org/10.1371/journal.pone.0315779 |
| spellingShingle | Elisa Leusmann Ciamak Abkai Michael Tittelbach Wigand Poppendieck Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. PLoS ONE |
| title | Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. |
| title_full | Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. |
| title_fullStr | Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. |
| title_full_unstemmed | Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. |
| title_short | Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application. |
| title_sort | quantification of safe operation conditions for large area platinum iridium electrodes in neurostimulation application |
| url | https://doi.org/10.1371/journal.pone.0315779 |
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