Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy
IntroductionThe aim of this study was to evaluate the clinical outcomes of spinal cord stimulation (SCS) in patients with painful diabetic peripheral neuropathy (PDPN).Materials and methodsNinety-two patients underwent permanent SCS implantation and completed a 6-month post-operative follow-up. The...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1619851/full |
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| author | Dongqiang Cui Ming Yang Yang Qiao Zhenxing Gong Zeqing Hu Zhuang Ma Yang Wu Guitong Huo |
| author_facet | Dongqiang Cui Ming Yang Yang Qiao Zhenxing Gong Zeqing Hu Zhuang Ma Yang Wu Guitong Huo |
| author_sort | Dongqiang Cui |
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| description | IntroductionThe aim of this study was to evaluate the clinical outcomes of spinal cord stimulation (SCS) in patients with painful diabetic peripheral neuropathy (PDPN).Materials and methodsNinety-two patients underwent permanent SCS implantation and completed a 6-month post-operative follow-up. The primary endpoint was patient amputation rate, and secondary endpoints included Quality of Life (QOL LC V2.0) scale, pain visual analogue scale (VAS), limb nerve conduction velocity, latency and amplitude, and vibration perception threshold (VPT).ResultsIn patients with diabetic peripheral neuropathy, QOL LC V2.0 and VAS scores were significantly improved at 6 months postoperatively compared to preoperatively (24.74%, p < 0.05; 71.87%, p < 0.05). Compared with the median and ulnar nerves of the upper extremity peripheral nerves, the conduction velocities of the common peroneal, sural, superficial peroneal and tibial nerves of the lower extremity peripheral nerves were increased (p < 0.05), the latency was significantly shortened (p < 0.05) and the amplitude was significantly increased (p < 0.05) at 6 months after surgery. Compared to the dorsum of the hand, VPTs were significantly lower in the first toe and dorsum of the foot at 6 months postoperatively compared to preoperatively (p < 0.05). The overall amputation rate was 8.69%, with 3.26% for major amputation (above the ankle) and 5.43% for minor amputation (below the ankle).ConclusionSCS can effectively relieve lower limb pain in patients with diabetic peripheral neuropathy, repair lower limb peripheral nerves, improve patients’ quality of life, and reduce amputation rate. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-e28bafca8de04c13819d6e7e15ad96762025-08-21T04:10:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16198511619851Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathyDongqiang Cui0Ming Yang1Yang Qiao2Zhenxing Gong3Zeqing Hu4Zhuang Ma5Yang Wu6Guitong Huo7Department of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Neurosurgery, Xingtai Ninth Hospital, Xingtai, ChinaIntroductionThe aim of this study was to evaluate the clinical outcomes of spinal cord stimulation (SCS) in patients with painful diabetic peripheral neuropathy (PDPN).Materials and methodsNinety-two patients underwent permanent SCS implantation and completed a 6-month post-operative follow-up. The primary endpoint was patient amputation rate, and secondary endpoints included Quality of Life (QOL LC V2.0) scale, pain visual analogue scale (VAS), limb nerve conduction velocity, latency and amplitude, and vibration perception threshold (VPT).ResultsIn patients with diabetic peripheral neuropathy, QOL LC V2.0 and VAS scores were significantly improved at 6 months postoperatively compared to preoperatively (24.74%, p < 0.05; 71.87%, p < 0.05). Compared with the median and ulnar nerves of the upper extremity peripheral nerves, the conduction velocities of the common peroneal, sural, superficial peroneal and tibial nerves of the lower extremity peripheral nerves were increased (p < 0.05), the latency was significantly shortened (p < 0.05) and the amplitude was significantly increased (p < 0.05) at 6 months after surgery. Compared to the dorsum of the hand, VPTs were significantly lower in the first toe and dorsum of the foot at 6 months postoperatively compared to preoperatively (p < 0.05). The overall amputation rate was 8.69%, with 3.26% for major amputation (above the ankle) and 5.43% for minor amputation (below the ankle).ConclusionSCS can effectively relieve lower limb pain in patients with diabetic peripheral neuropathy, repair lower limb peripheral nerves, improve patients’ quality of life, and reduce amputation rate.https://www.frontiersin.org/articles/10.3389/fneur.2025.1619851/fulldiabetic peripheral neuropathyspinal cord stimulationlower limb painneuromodulationpainful diabetic peripheral neuropathy |
| spellingShingle | Dongqiang Cui Ming Yang Yang Qiao Zhenxing Gong Zeqing Hu Zhuang Ma Yang Wu Guitong Huo Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy Frontiers in Neurology diabetic peripheral neuropathy spinal cord stimulation lower limb pain neuromodulation painful diabetic peripheral neuropathy |
| title | Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| title_full | Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| title_fullStr | Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| title_full_unstemmed | Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| title_short | Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| title_sort | retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy |
| topic | diabetic peripheral neuropathy spinal cord stimulation lower limb pain neuromodulation painful diabetic peripheral neuropathy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1619851/full |
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