Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture
Abstract Purpose Lipids increase osteoporosis and fracture risk, yet research on Atherogenic Index of Plasma (AIP), bone mineral density declines (BMD), and trabecular bone score (TBS) is limited. This study examined the relationships between AIP, TBS, and BMD in American adults using the National H...
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BMC
2025-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-05460-5 |
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| author | Bo Xu Guo-Liang Ma Xin Chen Bo-Wen Yang Dian Zhang Xiao-Kuan Qin Tai-Wei Lou Wei-Li Duan Le Yu Min-Shan Feng He Yin Xu Wei Li-Guo Zhu |
| author_facet | Bo Xu Guo-Liang Ma Xin Chen Bo-Wen Yang Dian Zhang Xiao-Kuan Qin Tai-Wei Lou Wei-Li Duan Le Yu Min-Shan Feng He Yin Xu Wei Li-Guo Zhu |
| author_sort | Bo Xu |
| collection | DOAJ |
| description | Abstract Purpose Lipids increase osteoporosis and fracture risk, yet research on Atherogenic Index of Plasma (AIP), bone mineral density declines (BMD), and trabecular bone score (TBS) is limited. This study examined the relationships between AIP, TBS, and BMD in American adults using the National Health and Nutrition Examination Survey (NHANES) data, including the effect of obesity. Methods Based on data from 3,162 Americans, multivariable logistic regression and a generalized additive model (GAM) were used to analyze AIP, BMD, and TBS. Mediation studies assessed the impact of obesity (BMI) on these relationships. A threshold effect study identified turning points. Results The average participant age was 47.5 ± 17 years. AIP showed no correlation with BMD after BMI adjustment but was significantly associated with lumbar spine and femoral neck BMD without BMI adjustment. AIP negatively correlated with TBS even after adjusting for covariates. The relationship between AIP and TBS was L-shaped, with a turning point at -0.17. BMI mediated the AIP-BMD relationship by 122.01–131.49% (P < 0.05). Conclusions This study found AIP levels associated with decreased TBS and increased BMD, influenced by obesity. AIP may be a valuable tool in evaluating bone metabolism, indicating high BMD but poor TBS, warranting further exploration. |
| format | Article |
| id | doaj-art-e252dc135e76484eaee2e1d3535d2477 |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-e252dc135e76484eaee2e1d3535d24772025-01-12T12:32:32ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-01-0120111110.1186/s13018-025-05460-5Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitectureBo Xu0Guo-Liang Ma1Xin Chen2Bo-Wen Yang3Dian Zhang4Xiao-Kuan Qin5Tai-Wei Lou6Wei-Li Duan7Le Yu8Min-Shan Feng9He Yin10Xu Wei11Li-Guo Zhu12Department of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesXiyuan Hospital, China Academy of Chinese Medical SciencesWangjing Hospital, Nanyang Hospital, Chinese Academy of Traditional Chinese Medicine (Dushan Hospital District)Beijing Changping District Integrated Traditional Chinese and Western Medicine HospitalDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical SciencesAbstract Purpose Lipids increase osteoporosis and fracture risk, yet research on Atherogenic Index of Plasma (AIP), bone mineral density declines (BMD), and trabecular bone score (TBS) is limited. This study examined the relationships between AIP, TBS, and BMD in American adults using the National Health and Nutrition Examination Survey (NHANES) data, including the effect of obesity. Methods Based on data from 3,162 Americans, multivariable logistic regression and a generalized additive model (GAM) were used to analyze AIP, BMD, and TBS. Mediation studies assessed the impact of obesity (BMI) on these relationships. A threshold effect study identified turning points. Results The average participant age was 47.5 ± 17 years. AIP showed no correlation with BMD after BMI adjustment but was significantly associated with lumbar spine and femoral neck BMD without BMI adjustment. AIP negatively correlated with TBS even after adjusting for covariates. The relationship between AIP and TBS was L-shaped, with a turning point at -0.17. BMI mediated the AIP-BMD relationship by 122.01–131.49% (P < 0.05). Conclusions This study found AIP levels associated with decreased TBS and increased BMD, influenced by obesity. AIP may be a valuable tool in evaluating bone metabolism, indicating high BMD but poor TBS, warranting further exploration.https://doi.org/10.1186/s13018-025-05460-5Bone mineral densityTrabecular bone scoreAtherogenic index of plasmaOsteoporosisNHANES |
| spellingShingle | Bo Xu Guo-Liang Ma Xin Chen Bo-Wen Yang Dian Zhang Xiao-Kuan Qin Tai-Wei Lou Wei-Li Duan Le Yu Min-Shan Feng He Yin Xu Wei Li-Guo Zhu Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture Journal of Orthopaedic Surgery and Research Bone mineral density Trabecular bone score Atherogenic index of plasma Osteoporosis NHANES |
| title | Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture |
| title_full | Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture |
| title_fullStr | Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture |
| title_full_unstemmed | Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture |
| title_short | Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture |
| title_sort | contradictory links between lipid levels and bone health atherogenic index of plasma and bone microarchitecture |
| topic | Bone mineral density Trabecular bone score Atherogenic index of plasma Osteoporosis NHANES |
| url | https://doi.org/10.1186/s13018-025-05460-5 |
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