Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study
Background It remains unclear whether or which prediagnostic lifestyle and dietary factors influence colorectal cancer (CRC) survival following diagnosis. This study used competing mortality risks analysis to evaluate the association between these factors and CRC survival.Methods A total of 96 889 c...
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| Language: | English |
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BMJ Publishing Group
2019-08-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/6/1/e000338.full |
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| author | Guri Skeie Tonje Braaten Sunday Oluwafemi Oyeyemi Kristin Benjaminsen Borch |
| author_facet | Guri Skeie Tonje Braaten Sunday Oluwafemi Oyeyemi Kristin Benjaminsen Borch |
| author_sort | Guri Skeie |
| collection | DOAJ |
| description | Background It remains unclear whether or which prediagnostic lifestyle and dietary factors influence colorectal cancer (CRC) survival following diagnosis. This study used competing mortality risks analysis to evaluate the association between these factors and CRC survival.Methods A total of 96 889 cancer-free participants of the Norwegian Women and Cancer Study completed the study’s baseline questionnaire on lifestyle and dietary factors between 1996 and 2004. Of the 1861 women who subsequently developed CRC, 550 had CRC as the cause of death, while 110 had a non-CRC cause of death. We used multiple imputation to handle missing data. We performed multivariable competing mortality risks analyses to determine the associations between prediagnostic lifestyle and dietary factors and CRC survival. Cause-specific HRs were estimated by Cox regression and subdistribution HRs were estimated by the Fine-Gray regression with corresponding 95% CIs.Results Following multivariable adjustment, a prediagnostic vitamin D intake of >10 μg/day compared with ≤10 μg/day was associated with better CRC survival (HR=0.75, 95% CI 0.61 to 0.92). Other prediagnostic lifestyle and dietary factors showed no association with CRC survival. The corresponding results obtained from cause-specific Cox and Fine-Gray regressions were similar.Conclusion Our study shows that prediagnostic vitamin D intake could improve CRC survival. |
| format | Article |
| id | doaj-art-e2473650f63d49c1a08970beac009b5d |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-e2473650f63d49c1a08970beac009b5d2024-12-15T06:25:09ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742019-08-016110.1136/bmjgast-2019-000338Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer StudyGuri Skeie0Tonje Braaten1Sunday Oluwafemi Oyeyemi2Kristin Benjaminsen Borch3Community Medicine, UiT The Arctic University of Norway, Tromso, Norway1 Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayCommunity Medicine, UiT The Arctic University of Norway, Tromso, Norway1 Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, NorwayBackground It remains unclear whether or which prediagnostic lifestyle and dietary factors influence colorectal cancer (CRC) survival following diagnosis. This study used competing mortality risks analysis to evaluate the association between these factors and CRC survival.Methods A total of 96 889 cancer-free participants of the Norwegian Women and Cancer Study completed the study’s baseline questionnaire on lifestyle and dietary factors between 1996 and 2004. Of the 1861 women who subsequently developed CRC, 550 had CRC as the cause of death, while 110 had a non-CRC cause of death. We used multiple imputation to handle missing data. We performed multivariable competing mortality risks analyses to determine the associations between prediagnostic lifestyle and dietary factors and CRC survival. Cause-specific HRs were estimated by Cox regression and subdistribution HRs were estimated by the Fine-Gray regression with corresponding 95% CIs.Results Following multivariable adjustment, a prediagnostic vitamin D intake of >10 μg/day compared with ≤10 μg/day was associated with better CRC survival (HR=0.75, 95% CI 0.61 to 0.92). Other prediagnostic lifestyle and dietary factors showed no association with CRC survival. The corresponding results obtained from cause-specific Cox and Fine-Gray regressions were similar.Conclusion Our study shows that prediagnostic vitamin D intake could improve CRC survival.https://bmjopengastro.bmj.com/content/6/1/e000338.full |
| spellingShingle | Guri Skeie Tonje Braaten Sunday Oluwafemi Oyeyemi Kristin Benjaminsen Borch Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study BMJ Open Gastroenterology |
| title | Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study |
| title_full | Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study |
| title_fullStr | Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study |
| title_full_unstemmed | Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study |
| title_short | Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study |
| title_sort | competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival the norwegian women and cancer study |
| url | https://bmjopengastro.bmj.com/content/6/1/e000338.full |
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