Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis
BackgroundThe purpose of this study is to investigate the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and death of K. pneumoniae infections in acute pancreatitis (AP) patients.MethodsThis was a retrospective analysis of AP patients with K. pneumoniae infection betwee...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1533765/full |
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| author | Jing Chen Qian Xiang Jia-yu Wu Xiao-Jia Zheng Xiao-yan Jiang |
| author_facet | Jing Chen Qian Xiang Jia-yu Wu Xiao-Jia Zheng Xiao-yan Jiang |
| author_sort | Jing Chen |
| collection | DOAJ |
| description | BackgroundThe purpose of this study is to investigate the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and death of K. pneumoniae infections in acute pancreatitis (AP) patients.MethodsThis was a retrospective analysis of AP patients with K. pneumoniae infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of K. pneumoniae infection.ResultsA total of 113 AP patients experienced K. pneumoniae infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group (P < 0.001). Only mechanical ventilation (OR = 2.301; 95% CI 1.02-5.20; P = 0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20–0.75; P = 0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10–7.82; P = 0.032) were the independent risk factors associated with mortality of K. pneumoniae infection in patients with AP.ConclusionKlebsiella pneumoniae infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis. |
| format | Article |
| id | doaj-art-e239257460224f99b2aaed76cecbb000 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-e239257460224f99b2aaed76cecbb0002025-01-17T06:50:57ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.15337651533765Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitisJing ChenQian XiangJia-yu WuXiao-Jia ZhengXiao-yan JiangBackgroundThe purpose of this study is to investigate the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and death of K. pneumoniae infections in acute pancreatitis (AP) patients.MethodsThis was a retrospective analysis of AP patients with K. pneumoniae infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of K. pneumoniae infection.ResultsA total of 113 AP patients experienced K. pneumoniae infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group (P < 0.001). Only mechanical ventilation (OR = 2.301; 95% CI 1.02-5.20; P = 0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20–0.75; P = 0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10–7.82; P = 0.032) were the independent risk factors associated with mortality of K. pneumoniae infection in patients with AP.ConclusionKlebsiella pneumoniae infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1533765/fullacute pancreatitisKlebsiella pneumoniaecarbapenem resistancerisk factormortality |
| spellingShingle | Jing Chen Qian Xiang Jia-yu Wu Xiao-Jia Zheng Xiao-yan Jiang Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis Frontiers in Public Health acute pancreatitis Klebsiella pneumoniae carbapenem resistance risk factor mortality |
| title | Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis |
| title_full | Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis |
| title_fullStr | Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis |
| title_full_unstemmed | Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis |
| title_short | Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis |
| title_sort | characteristics and risk factors for infection and mortality caused by klebsiella pneumoniae in patients with acute pancreatitis |
| topic | acute pancreatitis Klebsiella pneumoniae carbapenem resistance risk factor mortality |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1533765/full |
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