Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial
Abstract Background Night shift workers face increased risk of cardiovascular disease (CVD) compared to non-shift workers. Evidence supports on-shift napping and regular non-invasive monitoring of endothelial function for risk mitigation, yet neither strategy is widely used. Methods We evaluated the...
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BMC
2024-11-01
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| Series: | Pilot and Feasibility Studies |
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| Online Access: | https://doi.org/10.1186/s40814-024-01569-2 |
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| author | P. Daniel Patterson Cassie J. Hilditch Sarah E. Martin David G. L. Roach Matthew D. Weaver Tiffany S. Okerman David Hostler Leonard S. Weiss Steven E. Reis |
| author_facet | P. Daniel Patterson Cassie J. Hilditch Sarah E. Martin David G. L. Roach Matthew D. Weaver Tiffany S. Okerman David Hostler Leonard S. Weiss Steven E. Reis |
| author_sort | P. Daniel Patterson |
| collection | DOAJ |
| description | Abstract Background Night shift workers face increased risk of cardiovascular disease (CVD) compared to non-shift workers. Evidence supports on-shift napping and regular non-invasive monitoring of endothelial function for risk mitigation, yet neither strategy is widely used. Methods We evaluated the feasibility of non-invasive assessment of peripheral arterial tone (PAT) to assess the effect of napping during simulated night shift work on endothelial function. We used a single-site, randomized crossover trial of simulated night shift work with a 45-min nap condition versus a control, no-nap condition (ClinicalTrials.gov NCT05436951). Results The primary outcome was the number of participants with ≥ 70% of endothelial function assessments. Secondary outcomes included mean reactive hyperemia index (RHI), BP, and cognitive performance with the brief psychomotor vigilance task (PVT-B). Of the 10 consented, 9 completed both conditions. All participants exceeded feasibility benchmarks. Mean RHI did not differ by nap condition, and the delta from pre- to post measure did not differ (difference in delta = − 0.26, 95% CI − 1.09, 0.58). Hourly PVT-B assessments from 19:00 to 07:00 h did not differ by nap condition. Compared to pre-nap measures, cognitive performance on the PVT-B was poorest at + 0 min post-nap. Conclusion Our findings can inform larger studies evaluating the effects of night shift work and napping on endothelial function. Trial registrations ClinicalTrials.gov (NCT05436951, registered on June 23, 2022). |
| format | Article |
| id | doaj-art-e1fa3d267e844835a4064612ecd9d2d9 |
| institution | Kabale University |
| issn | 2055-5784 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Pilot and Feasibility Studies |
| spelling | doaj-art-e1fa3d267e844835a4064612ecd9d2d92024-11-17T12:10:15ZengBMCPilot and Feasibility Studies2055-57842024-11-0110111110.1186/s40814-024-01569-2Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trialP. Daniel Patterson0Cassie J. Hilditch1Sarah E. Martin2David G. L. Roach3Matthew D. Weaver4Tiffany S. Okerman5David Hostler6Leonard S. Weiss7Steven E. Reis8Department of Emergency Medicine, School of Medicine, University of PittsburghFatigue Countermeasures Laboratory, San José State UniversityDepartment of Emergency Medicine, School of Medicine, University of PittsburghDepartment of Emergency Medicine, School of Medicine, University of PittsburghDivision of Sleep and Circadian Disorders, Brigham and Women’s HospitalDepartment of Emergency Medicine, School of Medicine, University of PittsburghDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at BuffaloDepartment of Emergency Medicine, School of Medicine, University of PittsburghDepartment of Medicine, University of PittsburghAbstract Background Night shift workers face increased risk of cardiovascular disease (CVD) compared to non-shift workers. Evidence supports on-shift napping and regular non-invasive monitoring of endothelial function for risk mitigation, yet neither strategy is widely used. Methods We evaluated the feasibility of non-invasive assessment of peripheral arterial tone (PAT) to assess the effect of napping during simulated night shift work on endothelial function. We used a single-site, randomized crossover trial of simulated night shift work with a 45-min nap condition versus a control, no-nap condition (ClinicalTrials.gov NCT05436951). Results The primary outcome was the number of participants with ≥ 70% of endothelial function assessments. Secondary outcomes included mean reactive hyperemia index (RHI), BP, and cognitive performance with the brief psychomotor vigilance task (PVT-B). Of the 10 consented, 9 completed both conditions. All participants exceeded feasibility benchmarks. Mean RHI did not differ by nap condition, and the delta from pre- to post measure did not differ (difference in delta = − 0.26, 95% CI − 1.09, 0.58). Hourly PVT-B assessments from 19:00 to 07:00 h did not differ by nap condition. Compared to pre-nap measures, cognitive performance on the PVT-B was poorest at + 0 min post-nap. Conclusion Our findings can inform larger studies evaluating the effects of night shift work and napping on endothelial function. Trial registrations ClinicalTrials.gov (NCT05436951, registered on June 23, 2022).https://doi.org/10.1186/s40814-024-01569-2Night shift workNappingCardiovascular diseaseEndothelial functionSleep |
| spellingShingle | P. Daniel Patterson Cassie J. Hilditch Sarah E. Martin David G. L. Roach Matthew D. Weaver Tiffany S. Okerman David Hostler Leonard S. Weiss Steven E. Reis Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial Pilot and Feasibility Studies Night shift work Napping Cardiovascular disease Endothelial function Sleep |
| title | Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial |
| title_full | Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial |
| title_fullStr | Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial |
| title_full_unstemmed | Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial |
| title_short | Comparison of 45-min nap versus no-nap during simulated night shift work on endothelial function: a randomized crossover feasibility trial |
| title_sort | comparison of 45 min nap versus no nap during simulated night shift work on endothelial function a randomized crossover feasibility trial |
| topic | Night shift work Napping Cardiovascular disease Endothelial function Sleep |
| url | https://doi.org/10.1186/s40814-024-01569-2 |
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