Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse

Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse

Congenital ocular malformations originate from defective morphogenesis during early eye development and cause 25% of childhood blindness. Formation of the eye is a multi-step, dynamic process; it involves evagination of the optic vesicle, followed by distal and ventral invagination, leading to the f...

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Bibliographic Details
Main Authors: Katrina S. Hofstetter, Paula M. Haas, Jonathon P. Kuntz, Yi Zheng, Sabine Fuhrmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
retina
retinal disease
Microphthalmia
Coloboma
Cdc42
RPE
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1474010/full
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