Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair
With the rapid progress of industrialization, the incidence of peripheral nerve injuries caused by trauma has been continuously increasing. These injuries result in a significant number of disabilities and irreversible functional impairments, not only severely impacting the health and quality of lif...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1499766/full |
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| author | Pengjia Qiu Lei Wang Jing Wang Xingdong Wang Jianchao Xu Xiaokai An Fengwang Han Zhao Dong Jiangtao Zhang Peiwen Shi Qiang Niu |
| author_facet | Pengjia Qiu Lei Wang Jing Wang Xingdong Wang Jianchao Xu Xiaokai An Fengwang Han Zhao Dong Jiangtao Zhang Peiwen Shi Qiang Niu |
| author_sort | Pengjia Qiu |
| collection | DOAJ |
| description | With the rapid progress of industrialization, the incidence of peripheral nerve injuries caused by trauma has been continuously increasing. These injuries result in a significant number of disabilities and irreversible functional impairments, not only severely impacting the health and quality of life of patients but also placing a heavy economic burden on families and society. Effectively promoting peripheral nerve regeneration has thus become a key focus and challenge in current research. In recent years, hybrid biohydrogels with adhesive properties have gained widespread attention due to their excellent biocompatibility, mechanical stability, conductivity, and biodegradability. These materials can provide an optimal microenvironment to promote neuron adhesion and axonal extension while offering outstanding mechanical strength to meet the fixation requirements in clinical surgeries. This paper systematically reviews the application of adhesive hybrid biohydrogels in peripheral nerve injury repair, highlighting the latest research progress in promoting nerve regeneration and improving functional recovery, and discusses the challenges and future prospects for their clinical application. |
| format | Article |
| id | doaj-art-e1bdf9bde1004eef8bfb12c835b3960a |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-e1bdf9bde1004eef8bfb12c835b3960a2024-11-14T06:21:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-11-011210.3389/fcell.2024.14997661499766Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repairPengjia Qiu0Lei Wang1Jing Wang2Xingdong Wang3Jianchao Xu4Xiaokai An5Fengwang Han6Zhao Dong7Jiangtao Zhang8Peiwen Shi9Qiang Niu10Department of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Sichuan Gemflower Hospital, North Sichuan Medical College, Sichuan, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaDepartment of Orthopedics, Gaoyang County Hospital, Baoding, Hebei Province, ChinaWith the rapid progress of industrialization, the incidence of peripheral nerve injuries caused by trauma has been continuously increasing. These injuries result in a significant number of disabilities and irreversible functional impairments, not only severely impacting the health and quality of life of patients but also placing a heavy economic burden on families and society. Effectively promoting peripheral nerve regeneration has thus become a key focus and challenge in current research. In recent years, hybrid biohydrogels with adhesive properties have gained widespread attention due to their excellent biocompatibility, mechanical stability, conductivity, and biodegradability. These materials can provide an optimal microenvironment to promote neuron adhesion and axonal extension while offering outstanding mechanical strength to meet the fixation requirements in clinical surgeries. This paper systematically reviews the application of adhesive hybrid biohydrogels in peripheral nerve injury repair, highlighting the latest research progress in promoting nerve regeneration and improving functional recovery, and discusses the challenges and future prospects for their clinical application.https://www.frontiersin.org/articles/10.3389/fcell.2024.1499766/fulltraumatic injuryadhesion materialschitosan-based hydrogelhybrid biohydrogelperipheral nerve injury |
| spellingShingle | Pengjia Qiu Lei Wang Jing Wang Xingdong Wang Jianchao Xu Xiaokai An Fengwang Han Zhao Dong Jiangtao Zhang Peiwen Shi Qiang Niu Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair Frontiers in Cell and Developmental Biology traumatic injury adhesion materials chitosan-based hydrogel hybrid biohydrogel peripheral nerve injury |
| title | Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair |
| title_full | Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair |
| title_fullStr | Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair |
| title_full_unstemmed | Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair |
| title_short | Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair |
| title_sort | adhesive chitosan based hybrid biohydrogels for peripheral nerve injury repair |
| topic | traumatic injury adhesion materials chitosan-based hydrogel hybrid biohydrogel peripheral nerve injury |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1499766/full |
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