抑制<italic>miR</italic>-<italic>4321</italic>减轻脓毒症相关急性肾脏损伤的作用和机制研究

抑制<italic>miR</italic>-<italic>4321</italic>减轻脓毒症相关急性肾脏损伤的作用和机制研究

目的本研究旨在探讨抑制<italic>miR-4321</italic>在改善脓毒症相关急性肾损伤（Sepsis associated acute kidney injury， SA-AKI）中的作用和机制。方法采用RT-qPCR方法检测LPS诱导的HK2细胞模型和CLP模型小鼠肾脏组织中<italic>miR-3165</italic>、<italic>miR-4270</italic>和<italic>miR-4321</italic>的表达水平。利用<italic>miR-4321...

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Bibliographic Details
Main Authors: 张春敏, 陈飞燕, 杨文敏, 林永敏, 毛碧涛, 陈洁, 武志远, 梁宇峰
Format: Article
Language:zho
Published: Editorial Office of Journal of Sun Yat-sen University 2022-11-01
Series:Zhongshan Daxue xuebao. Yixue kexue ban
Subjects:
脓毒症相关急性肾损伤
脂多糖
<italic>miR-4321</italic>
mTOR
Online Access:http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0608/
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