Safety and Efficacy of Combination Therapy with Anti-Vascular Endothelial Growth Factor and Laser for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis
Anas Alamoudi,1 Ahmed N Alnabihi,2,3 Ali Saleh Alsudais,2,3 Naif Almufarriji,1 Waleed T Batais,2,3 Abdulaziz Khalid Aldahlawi,2,3 Abdullah Altalhi,4 Hassan A Al-Dhibi,5 Adel G Alakeely6 1Department of Ophthalmology, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud Bin Abdul...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/safety-and-efficacy-of-combination-therapy-with-anti-vascular-endothel-peer-reviewed-fulltext-article-OPTH |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Anas Alamoudi,1 Ahmed N Alnabihi,2,3 Ali Saleh Alsudais,2,3 Naif Almufarriji,1 Waleed T Batais,2,3 Abdulaziz Khalid Aldahlawi,2,3 Abdullah Altalhi,4 Hassan A Al-Dhibi,5 Adel G Alakeely6 1Department of Ophthalmology, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 3King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 4Division of Vitreoretinal Surgery, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 5Division of Vitreoretinal Surgery and Uveitis, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 6Magrabi Hospitals and Centers, Riyadh, Saudi ArabiaCorrespondence: Anas Alamoudi, Department of Ophthalmology, Jeddah Eye Hospital, Jeddah, Saudi Arabia, Email anasalamoudi99@gmail.comAim: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of combined laser and anti-VEGF therapy for (retinopathy of prematurity ROP), focusing on both structural and functional outcomes.Methods: A comprehensive search was conducted in multiple databases to identify randomized controlled trials (RCTs) that investigated combination therapy for ROP. The PRISMA guidelines were followed. Data were extracted and analyzed using risk ratios and 95% confidence intervals (CIs). The Cochrane Risk of Bias tool was used to assess the risk of bias.Results: Three RCTs involving a total of 162 premature infants were included in the meta-analysis. Combination therapy of anti-VEGF and laser photocoagulation was compared with other interventions. The pooled analysis of favorable structural outcomes did not show a statistically significant difference between combination therapy with anti-VEGFs and laser therapy compared to the interventions in the control groups (P=0.25). The incidence of adverse events was comparable between the combination therapy group and other intervention groups.Conclusion: This systematic review and meta-analysis suggest that risk ratio of combination therapy with anti-VEGF and laser for ROP is associated with favorable outcomes, albeit insignificant. The safety profile of combination therapy appears to be similar to other interventions. However, due to the limited number of included studies, further research is needed.Keywords: neonatal retinal disease, angiogenesis inhibitors, retinal photocoagulation, premature infant eye health |
|---|---|
| ISSN: | 1177-5483 |