The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review
Since the publication of the Adverse Childhood Experiences (ACEs) Study in 1998, there has been a dramatic increase in the number of studies exploring the immunoendocrinological sequelae of toxic stress. However, the literature exploring this in relation to paediatric atopy predominantly revolves ar...
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MDPI AG
2024-10-01
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| author | Julian Ang Farshid Bayat Aoife Gallagher David O’Keeffe Melissa Isabella Meyer Roberto Velasco Zaheera Yusuf Juan Trujillo |
| author_facet | Julian Ang Farshid Bayat Aoife Gallagher David O’Keeffe Melissa Isabella Meyer Roberto Velasco Zaheera Yusuf Juan Trujillo |
| author_sort | Julian Ang |
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| description | Since the publication of the Adverse Childhood Experiences (ACEs) Study in 1998, there has been a dramatic increase in the number of studies exploring the immunoendocrinological sequelae of toxic stress. However, the literature exploring this in relation to paediatric atopy predominantly revolves around asthma. This review aims to (1) explore the association between ACEs and non-asthmatic, non-iatrogenic paediatric allergies (NANIPA) in the developed world and (2) further focus on the association between exposure to violence and NANIPA. Methods: PubMed and Scopus were searched for articles examining adversity and NANIPA before age 18. Non-English papers, publications before 1998, reviews, opinion pieces and case reports/series were excluded. Screening, data extraction, and risk-of-bias were independently reviewed by the first two authors. Results: Nine of the one thousand eighty-nine records identified were included. Four pertained to objective 1, four to objective 2, and one pertained to both. Regarding objective 1, all studies reported a positive dose-response relationship between ACEs and NANIPA, which was most significant among preschoolers and diminished with age. Studies relevant to objective 2 were too heterogenous to compare. However, two interesting associations emerged: (1) The types of violence significantly associated with NANIPA in adolescence differ in a sex-dependent manner, and (2) verbal abuse and bullying are the violence types most powerfully and significantly associated with NANIPA. Conclusion: Psychological stress is a probable IgE-independent driver of atopy in children exposed to adversity and/or violence. While the literature is too underdeveloped to allow for meaningful cross-comparison between studies, this review has identified many interesting areas for future research. |
| format | Article |
| id | doaj-art-e1a022470ef74bae8a9adb10b52ac70b |
| institution | Kabale University |
| issn | 2313-5786 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Allergies |
| spelling | doaj-art-e1a022470ef74bae8a9adb10b52ac70b2024-12-27T14:05:21ZengMDPI AGAllergies2313-57862024-10-014416218010.3390/allergies4040012The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic ReviewJulian Ang0Farshid Bayat1Aoife Gallagher2David O’Keeffe3Melissa Isabella Meyer4Roberto Velasco5Zaheera Yusuf6Juan Trujillo7Department of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandAcute and Integrated Medicine Division, Northwick Park Hospital, London North West University Healthcare NHS Trust, London HA1 3UJ, UKDepartment of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandDepartment of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandDepartment of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandPaediatric Emergency Unit, Hospital Universitari Parc Tauli Barcelona, 08208 Barcelona, SpainDepartment of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandDepartment of Paediatrics, Cork University Hospital, T12 DC4A Cork, IrelandSince the publication of the Adverse Childhood Experiences (ACEs) Study in 1998, there has been a dramatic increase in the number of studies exploring the immunoendocrinological sequelae of toxic stress. However, the literature exploring this in relation to paediatric atopy predominantly revolves around asthma. This review aims to (1) explore the association between ACEs and non-asthmatic, non-iatrogenic paediatric allergies (NANIPA) in the developed world and (2) further focus on the association between exposure to violence and NANIPA. Methods: PubMed and Scopus were searched for articles examining adversity and NANIPA before age 18. Non-English papers, publications before 1998, reviews, opinion pieces and case reports/series were excluded. Screening, data extraction, and risk-of-bias were independently reviewed by the first two authors. Results: Nine of the one thousand eighty-nine records identified were included. Four pertained to objective 1, four to objective 2, and one pertained to both. Regarding objective 1, all studies reported a positive dose-response relationship between ACEs and NANIPA, which was most significant among preschoolers and diminished with age. Studies relevant to objective 2 were too heterogenous to compare. However, two interesting associations emerged: (1) The types of violence significantly associated with NANIPA in adolescence differ in a sex-dependent manner, and (2) verbal abuse and bullying are the violence types most powerfully and significantly associated with NANIPA. Conclusion: Psychological stress is a probable IgE-independent driver of atopy in children exposed to adversity and/or violence. While the literature is too underdeveloped to allow for meaningful cross-comparison between studies, this review has identified many interesting areas for future research.https://www.mdpi.com/2313-5786/4/4/12adverse childhood experiencechildhood adversitytoxic stresspaediatric allergypaediatric atopy |
| spellingShingle | Julian Ang Farshid Bayat Aoife Gallagher David O’Keeffe Melissa Isabella Meyer Roberto Velasco Zaheera Yusuf Juan Trujillo The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review Allergies adverse childhood experience childhood adversity toxic stress paediatric allergy paediatric atopy |
| title | The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review |
| title_full | The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review |
| title_fullStr | The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review |
| title_full_unstemmed | The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review |
| title_short | The Relationship between Adverse Childhood Experiences and Non-Asthmatic Allergies: A Systematic Review |
| title_sort | relationship between adverse childhood experiences and non asthmatic allergies a systematic review |
| topic | adverse childhood experience childhood adversity toxic stress paediatric allergy paediatric atopy |
| url | https://www.mdpi.com/2313-5786/4/4/12 |
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