Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis
Abstract Background Residual back pain (RBP) following vertebral augmentation negatively impacts clinical satisfaction and compromises both the physical and psychological well-being of affected patients. This meta-analysis aimed to identify risk factors associated with RBP after vertebral augmentati...
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2025-07-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08945-w |
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| author | Haozhong Wang Hao Zhang Changming Xiao Kaiquan Zhang Lisheng Qi |
| author_facet | Haozhong Wang Hao Zhang Changming Xiao Kaiquan Zhang Lisheng Qi |
| author_sort | Haozhong Wang |
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| description | Abstract Background Residual back pain (RBP) following vertebral augmentation negatively impacts clinical satisfaction and compromises both the physical and psychological well-being of affected patients. This meta-analysis aimed to identify risk factors associated with RBP after vertebral augmentation in patients with osteoporotic vertebral compression fractures (OVCF). Methods We searched literature in the PubMed, Embase, Web of Science and Cochrane Library. PRISMA guidelines were followed in this review. The Newcastle–Ottawa Scale (NOS) were used to evaluate the quality of included studies. Odds ratio (OR), mean difference (MD) and 95% confidence interval (CI) of potential risk factors were calculated via RevMan5.4. Results A total of 11 studies and 3290 patients were included in this meta-analysis. 12 risk factors were assessed and the outcome showed that lower BMD (MD = 0.39, 95% CI 0.27 ~ 0.52, p < 0.01), lower BMI (MD = -1.22, 95% CI -2.38 ~ -0.06, p = 0.04), depression (OR = 2.72, 95% CI 1.48 ~ 5.01, p < 0.01), adjacent vertebral fracture (OR = 2.53, 95% CI 1.42 ~ 4.50, p < 0.01), posterior fascia injury (OR = 3.94, 95% CI 3.10 ~ 5.00, p < 0.01), intravertebral vacuum cleft (OR = 2.33, 95% CI 1.56 ~ 3.50, p < 0.01), severe paraspinal muscle degeneration (OR = 6.25, 95% CI 4.09 ~ 9.53, p < 0.01), facet joint violation (OR = 7.71, 95% CI 3.50 ~ 17.00, p < 0.01), unsatisfied bone cement distribution (OR = 2.82, 95% CI 1.67 ~ 4.76, p < 0.01), less bone cement volume (MD = -0.24, 95% CI -0.45 ~ -0.03, p = 0.02), less recovery rate of anterior vertebral height (MD = -3.46, 95% CI -6.22 ~ -6.09, p = 0.01), less postoperative local kyphosis correction rate (MD = -4.74, 95% CI -6.43 ~ -3.06, p < 0.01) were associated with postoperative RBP in OVCF patients. Conclusion Lower BMD, lower BMI, depression, adjacent vertebral fracture, posterior fascia injury, intravertebral vacuum cleft, severe paraspinal muscle degeneration, facet joint violation, unsatisfied bone cement distribution, less bone cement volume, less recovery rate of anterior vertebral height, and less postoperative local kyphosis correction rate were associated with an increased risk of RBP after vertebral augmentation in OVCF patients. Early identification and targeted management of high-risk patients may help reduce RBP incidence. |
| format | Article |
| id | doaj-art-e19c20c3e6cc437ebc8cb9b2ec49e33e |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-07-01 |
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| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-e19c20c3e6cc437ebc8cb9b2ec49e33e2025-08-20T03:45:39ZengBMCBMC Musculoskeletal Disorders1471-24742025-07-0126111610.1186/s12891-025-08945-wRisk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysisHaozhong Wang0Hao Zhang1Changming Xiao2Kaiquan Zhang3Lisheng Qi4Department of Orthopedic Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Orthopedic Surgery, People’s Hospital of LinshuiDepartment of Orthopedic Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Orthopedic Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityDepartment of Orthopedic Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityAbstract Background Residual back pain (RBP) following vertebral augmentation negatively impacts clinical satisfaction and compromises both the physical and psychological well-being of affected patients. This meta-analysis aimed to identify risk factors associated with RBP after vertebral augmentation in patients with osteoporotic vertebral compression fractures (OVCF). Methods We searched literature in the PubMed, Embase, Web of Science and Cochrane Library. PRISMA guidelines were followed in this review. The Newcastle–Ottawa Scale (NOS) were used to evaluate the quality of included studies. Odds ratio (OR), mean difference (MD) and 95% confidence interval (CI) of potential risk factors were calculated via RevMan5.4. Results A total of 11 studies and 3290 patients were included in this meta-analysis. 12 risk factors were assessed and the outcome showed that lower BMD (MD = 0.39, 95% CI 0.27 ~ 0.52, p < 0.01), lower BMI (MD = -1.22, 95% CI -2.38 ~ -0.06, p = 0.04), depression (OR = 2.72, 95% CI 1.48 ~ 5.01, p < 0.01), adjacent vertebral fracture (OR = 2.53, 95% CI 1.42 ~ 4.50, p < 0.01), posterior fascia injury (OR = 3.94, 95% CI 3.10 ~ 5.00, p < 0.01), intravertebral vacuum cleft (OR = 2.33, 95% CI 1.56 ~ 3.50, p < 0.01), severe paraspinal muscle degeneration (OR = 6.25, 95% CI 4.09 ~ 9.53, p < 0.01), facet joint violation (OR = 7.71, 95% CI 3.50 ~ 17.00, p < 0.01), unsatisfied bone cement distribution (OR = 2.82, 95% CI 1.67 ~ 4.76, p < 0.01), less bone cement volume (MD = -0.24, 95% CI -0.45 ~ -0.03, p = 0.02), less recovery rate of anterior vertebral height (MD = -3.46, 95% CI -6.22 ~ -6.09, p = 0.01), less postoperative local kyphosis correction rate (MD = -4.74, 95% CI -6.43 ~ -3.06, p < 0.01) were associated with postoperative RBP in OVCF patients. Conclusion Lower BMD, lower BMI, depression, adjacent vertebral fracture, posterior fascia injury, intravertebral vacuum cleft, severe paraspinal muscle degeneration, facet joint violation, unsatisfied bone cement distribution, less bone cement volume, less recovery rate of anterior vertebral height, and less postoperative local kyphosis correction rate were associated with an increased risk of RBP after vertebral augmentation in OVCF patients. Early identification and targeted management of high-risk patients may help reduce RBP incidence.https://doi.org/10.1186/s12891-025-08945-wResidual back painPercutaneous vertebroplastyPercutaneous kyphoplastyVertebral augmentationRisk factorMeta-analysis |
| spellingShingle | Haozhong Wang Hao Zhang Changming Xiao Kaiquan Zhang Lisheng Qi Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis BMC Musculoskeletal Disorders Residual back pain Percutaneous vertebroplasty Percutaneous kyphoplasty Vertebral augmentation Risk factor Meta-analysis |
| title | Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis |
| title_full | Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis |
| title_fullStr | Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis |
| title_full_unstemmed | Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis |
| title_short | Risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis |
| title_sort | risk factors of residual back pain after vertebral augmentation in osteoporotic vertebral compression fracture patients a systematic review and meta analysis |
| topic | Residual back pain Percutaneous vertebroplasty Percutaneous kyphoplasty Vertebral augmentation Risk factor Meta-analysis |
| url | https://doi.org/10.1186/s12891-025-08945-w |
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