Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review
Abstract The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improv...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-024-00442-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846171777550516224 |
|---|---|
| author | Daan W. A. van den Nieuwenhof Lorenzo Moroni Joshua Chou Jochen Hinkelbein |
| author_facet | Daan W. A. van den Nieuwenhof Lorenzo Moroni Joshua Chou Jochen Hinkelbein |
| author_sort | Daan W. A. van den Nieuwenhof |
| collection | DOAJ |
| description | Abstract The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine. |
| format | Article |
| id | doaj-art-e197ec02e1874b22b923eda30b429df3 |
| institution | Kabale University |
| issn | 2373-8065 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj-art-e197ec02e1874b22b923eda30b429df32024-11-10T12:36:03ZengNature Portfolionpj Microgravity2373-80652024-11-0110111610.1038/s41526-024-00442-zCellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative reviewDaan W. A. van den Nieuwenhof0Lorenzo Moroni1Joshua Chou2Jochen Hinkelbein3Department of Otorhinolaryngology, Radboud University Medical CenterMERLN Institute for Technology-Inspired Regenerative Medicine, Department of Complex Tissue Engineering, Maastricht UniversityUniversity of Technology Sydney (UTS)Department of Anesthesiology, Intensive Care Medicine and Emergency Medicine, Johannes Wesling Klinikum Minden, University Hospital Ruhr University BochumAbstract The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.https://doi.org/10.1038/s41526-024-00442-z |
| spellingShingle | Daan W. A. van den Nieuwenhof Lorenzo Moroni Joshua Chou Jochen Hinkelbein Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review npj Microgravity |
| title | Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review |
| title_full | Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review |
| title_fullStr | Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review |
| title_full_unstemmed | Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review |
| title_short | Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review |
| title_sort | cellular response in three dimensional spheroids and tissues exposed to real and simulated microgravity a narrative review |
| url | https://doi.org/10.1038/s41526-024-00442-z |
| work_keys_str_mv | AT daanwavandennieuwenhof cellularresponseinthreedimensionalspheroidsandtissuesexposedtorealandsimulatedmicrogravityanarrativereview AT lorenzomoroni cellularresponseinthreedimensionalspheroidsandtissuesexposedtorealandsimulatedmicrogravityanarrativereview AT joshuachou cellularresponseinthreedimensionalspheroidsandtissuesexposedtorealandsimulatedmicrogravityanarrativereview AT jochenhinkelbein cellularresponseinthreedimensionalspheroidsandtissuesexposedtorealandsimulatedmicrogravityanarrativereview |