Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study
Objectives This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | The Aging Male |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2024.2449341 |
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| author | Wentao Yao Jiacheng Wu Hongzhi Wang Zongming Jia Yinyi Zhou Chendi Yang Feng Xu Ying Kong Yuhua Huang |
| author_facet | Wentao Yao Jiacheng Wu Hongzhi Wang Zongming Jia Yinyi Zhou Chendi Yang Feng Xu Ying Kong Yuhua Huang |
| author_sort | Wentao Yao |
| collection | DOAJ |
| description | Objectives This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.Results Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [−0.075 (−0.145, −0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [−0.282 (−0.557, −0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.Conclusion In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70. |
| format | Article |
| id | doaj-art-e17d9229df734d588bf6ad737deef9e5 |
| institution | Kabale University |
| issn | 1368-5538 1473-0790 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Aging Male |
| spelling | doaj-art-e17d9229df734d588bf6ad737deef9e52025-01-08T12:42:42ZengTaylor & Francis GroupThe Aging Male1368-55381473-07902025-12-0128110.1080/13685538.2024.2449341Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional studyWentao Yao0Jiacheng Wu1Hongzhi Wang2Zongming Jia3Yinyi Zhou4Chendi Yang5Feng Xu6Ying Kong7Yuhua Huang8Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Urology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Urology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaObjectives This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.Results Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [−0.075 (−0.145, −0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [−0.282 (−0.557, −0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.Conclusion In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.https://www.tandfonline.com/doi/10.1080/13685538.2024.2449341Visceral adiposity indexprostate-specific antigenprostate cancermen aged 40 years and olderNHANES |
| spellingShingle | Wentao Yao Jiacheng Wu Hongzhi Wang Zongming Jia Yinyi Zhou Chendi Yang Feng Xu Ying Kong Yuhua Huang Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study The Aging Male Visceral adiposity index prostate-specific antigen prostate cancer men aged 40 years and older NHANES |
| title | Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study |
| title_full | Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study |
| title_fullStr | Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study |
| title_full_unstemmed | Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study |
| title_short | Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study |
| title_sort | association between visceral adiposity index and prostate cancer in men aged 40 years and older a nationwide cross sectional study |
| topic | Visceral adiposity index prostate-specific antigen prostate cancer men aged 40 years and older NHANES |
| url | https://www.tandfonline.com/doi/10.1080/13685538.2024.2449341 |
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