Amyloidosis Presenting as a Solitary Nasal Mass
Amyloidosis is characterized by extracellular deposition of amyloid fibrils. Localized collection of amyloid material in the form of a mass is extremely rare. Mr. M presented with epistaxis and was found to have a friable mass in the right maxillary antrum. Excision was followed by the resolution of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-10-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/INJMS.INJMS_82_20 |
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| _version_ | 1849224549202132992 |
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| author | Suvir Singh |
| author_facet | Suvir Singh |
| author_sort | Suvir Singh |
| collection | DOAJ |
| description | Amyloidosis is characterized by extracellular deposition of amyloid fibrils. Localized collection of amyloid material in the form of a mass is extremely rare. Mr. M presented with epistaxis and was found to have a friable mass in the right maxillary antrum. Excision was followed by the resolution of symptoms, and histopathology revealed subepithelial collection of amorphous pink material. It was positive for methyl violet and Congo red stain and showed apple-green birefringence. Staining for serum amyloid A and kappa/lambda light chains were negative. Workup for multiple myeloma, positron emission tomography scan for other masses, and screening for end-organ damage was also negative. He continues to be asymptomatic on observation 1-year after presentation. Amyloidosis presenting as a nasal mass has been described in less than five patients so far. Local excision appears to be the best treatment and is associated with a low risk of recurrence on long-term follow-up. |
| format | Article |
| id | doaj-art-e12598eca1ab4cf9baf3e9adf8f787c3 |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-e12598eca1ab4cf9baf3e9adf8f787c32025-08-25T08:33:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922020-10-0111421721910.4103/INJMS.INJMS_82_20Amyloidosis Presenting as a Solitary Nasal MassSuvir SinghAmyloidosis is characterized by extracellular deposition of amyloid fibrils. Localized collection of amyloid material in the form of a mass is extremely rare. Mr. M presented with epistaxis and was found to have a friable mass in the right maxillary antrum. Excision was followed by the resolution of symptoms, and histopathology revealed subepithelial collection of amorphous pink material. It was positive for methyl violet and Congo red stain and showed apple-green birefringence. Staining for serum amyloid A and kappa/lambda light chains were negative. Workup for multiple myeloma, positron emission tomography scan for other masses, and screening for end-organ damage was also negative. He continues to be asymptomatic on observation 1-year after presentation. Amyloidosis presenting as a nasal mass has been described in less than five patients so far. Local excision appears to be the best treatment and is associated with a low risk of recurrence on long-term follow-up.https://journals.lww.com/10.4103/INJMS.INJMS_82_20amyloidepistaxiskidneymyeloma |
| spellingShingle | Suvir Singh Amyloidosis Presenting as a Solitary Nasal Mass Indian Journal of Medical Specialities amyloid epistaxis kidney myeloma |
| title | Amyloidosis Presenting as a Solitary Nasal Mass |
| title_full | Amyloidosis Presenting as a Solitary Nasal Mass |
| title_fullStr | Amyloidosis Presenting as a Solitary Nasal Mass |
| title_full_unstemmed | Amyloidosis Presenting as a Solitary Nasal Mass |
| title_short | Amyloidosis Presenting as a Solitary Nasal Mass |
| title_sort | amyloidosis presenting as a solitary nasal mass |
| topic | amyloid epistaxis kidney myeloma |
| url | https://journals.lww.com/10.4103/INJMS.INJMS_82_20 |
| work_keys_str_mv | AT suvirsingh amyloidosispresentingasasolitarynasalmass |