Quantum Dots‐caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome

Quantum Dots‐caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome

Abstract Quantum dots (QDs) are widely used, but their health impact on the visual system is little known. This study aims to elucidate the effects and mechanisms of typical metallic QDs on retinas using zebrafish. Comprehensive histology, imaging, and bulk RNA sequencing reveal that InP/ZnS QDs cau...

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Main Authors: Naying Zheng, Tingting Liao, Chuchu Zhang, Zheyang Zhang, Sen Yan, Xiaohan Xi, Fengkai Ruan, Chunyan Yang, Qingliang Zhao, Wenbo Deng, Jialiang Huang, Zi‐Tao Huang, Zhi‐Feng Chen, Xiang Wang, Qingming Qu, Zhenghong Zuo, Chengyong He
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
Ferroptosis
Quantum dots
Retinal degeneration
Single‐cell RNA sequencing
Spliceosome
Online Access:https://doi.org/10.1002/advs.202406343
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