Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study [version 2; peer review: 1 approved, 2 approved with reservations]

Kadukkai maathirai (Indian herbal drug) prevents hepatocellular cancer progression by enhancing GSTM1 expression and modulating β catenin transcription: in-silico and in-vivo study [version 2; peer review: 1 approved, 2 approved with reservations]

Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in h...

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Main Authors: Akshatha Shetty, Shama Prasada K, Diya Rajasekhar Chinta, Ganesh Shenoy, Amruth Kiran, Vasudha Devi, Arul Amuthan, Smita Shenoy, Manjunath Shetty, Mohandas Rao K G, Nitesh Kumar
Format: Article
Language:English
Published: F1000 Research Ltd 2024-10-01
Series:F1000Research
Subjects:
β catenin
Glutathione-S transferase mu 1
Siddha
herbal
Diethyl nitrosamine
eng
Online Access:https://f1000research.com/articles/13-639/v2
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