CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer
The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (C...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037024004227 |
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| author | Darja Marolt Presen Duško Lainšček Jane Kinghorn Zsolt Sebestyen Jurgen Kuball Leila Amini Petra Reinke Anke Fuchs Roman Jerala Mojca Benčina |
| author_facet | Darja Marolt Presen Duško Lainšček Jane Kinghorn Zsolt Sebestyen Jurgen Kuball Leila Amini Petra Reinke Anke Fuchs Roman Jerala Mojca Benčina |
| author_sort | Darja Marolt Presen |
| collection | DOAJ |
| description | The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) at the National Institute of Chemistry (NIC) in Ljubljana represents a significant step forward, as it is the first centre of its kind in Slovenia. The CTGCT is poised to spearhead advances in cancer immunotherapy and personalised therapies for neurological and other rare genetic diseases. The centre’s overarching mission is to extend beyond the NIC’s scientific excellence in basic research and bring new therapeutic solutions toward clinical application. The CTGCT aims to develop a broad pipeline of biomedical tools, including innovative synthetic biology tools, gene editing and splicing technologies, RNA-based technologies, immune regulation engineering and novel viral and non-viral delivery systems. The CTGCT is supported by partner institutions from the UK, the Netherlands and Germany, which already have academic good manufacturing practice (GMP) facilities for the manufacture of advanced therapy medicinal products (ATMPs) and is committed to active collaboration with clinicians and patient organizations at all stages of development to improve access to gene and cell therapies (GCTs) for patients. The Centre also seeks to collaborate with national and international academic and industrial partners, and the newly established GMP facilities will address a critical bottleneck in the translation of GCTs from research to practice. Finally, CTGCT's translational research and technology transfer units will ensure the impactful dissemination of research and innovation activities in Slovenia, throughout the Western Balkans and Eastern Europe region, and beyond. With its comprehensive approach and forward-looking vision, the CTGCT will drive transformative advances in gene and cell therapies for the benefit of patients on a global scale. |
| format | Article |
| id | doaj-art-e0e2f9fb97a74787b4a70fbb52df83d0 |
| institution | Kabale University |
| issn | 2001-0370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj-art-e0e2f9fb97a74787b4a70fbb52df83d02024-12-13T10:57:09ZengElsevierComputational and Structural Biotechnology Journal2001-03702025-01-01271016CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancerDarja Marolt Presen0Duško Lainšček1Jane Kinghorn2Zsolt Sebestyen3Jurgen Kuball4Leila Amini5Petra Reinke6Anke Fuchs7Roman Jerala8Mojca Benčina9Centre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, SloveniaCentre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia; Department for Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, SloveniaTranslational Research Office, Innovation & Enterprise, University College London, Gower Street, London WC1E 6BT, UKCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsBerlin Center for Advanced Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health - Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, GermanyBerlin Center for Advanced Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health - Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, GermanyCenter for Regenerative Therapies Dresden, Center for Molecular and Cellular Bioengeneering, Technische Universität Dresden, Dresden, GermanyCentre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia; Department for Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, SloveniaCentre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia; Department for Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia; Corresponding author at: Centre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia.The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) at the National Institute of Chemistry (NIC) in Ljubljana represents a significant step forward, as it is the first centre of its kind in Slovenia. The CTGCT is poised to spearhead advances in cancer immunotherapy and personalised therapies for neurological and other rare genetic diseases. The centre’s overarching mission is to extend beyond the NIC’s scientific excellence in basic research and bring new therapeutic solutions toward clinical application. The CTGCT aims to develop a broad pipeline of biomedical tools, including innovative synthetic biology tools, gene editing and splicing technologies, RNA-based technologies, immune regulation engineering and novel viral and non-viral delivery systems. The CTGCT is supported by partner institutions from the UK, the Netherlands and Germany, which already have academic good manufacturing practice (GMP) facilities for the manufacture of advanced therapy medicinal products (ATMPs) and is committed to active collaboration with clinicians and patient organizations at all stages of development to improve access to gene and cell therapies (GCTs) for patients. The Centre also seeks to collaborate with national and international academic and industrial partners, and the newly established GMP facilities will address a critical bottleneck in the translation of GCTs from research to practice. Finally, CTGCT's translational research and technology transfer units will ensure the impactful dissemination of research and innovation activities in Slovenia, throughout the Western Balkans and Eastern Europe region, and beyond. With its comprehensive approach and forward-looking vision, the CTGCT will drive transformative advances in gene and cell therapies for the benefit of patients on a global scale.http://www.sciencedirect.com/science/article/pii/S2001037024004227Gene therapyCell therapyNeurological diseasesCancer immunotherapySynthetic biologyTranslational medicine |
| spellingShingle | Darja Marolt Presen Duško Lainšček Jane Kinghorn Zsolt Sebestyen Jurgen Kuball Leila Amini Petra Reinke Anke Fuchs Roman Jerala Mojca Benčina CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer Computational and Structural Biotechnology Journal Gene therapy Cell therapy Neurological diseases Cancer immunotherapy Synthetic biology Translational medicine |
| title | CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| title_full | CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| title_fullStr | CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| title_full_unstemmed | CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| title_short | CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| title_sort | ctgct centre of excellence for the technologies of gene and cell therapy collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer |
| topic | Gene therapy Cell therapy Neurological diseases Cancer immunotherapy Synthetic biology Translational medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2001037024004227 |
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