A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients
Abstract The nature of somatotroph adenomas has not been clearly revealed in studies. We consider that there are macroscopic differences in intraoperative tumor consistency in acromegaly patients. We aimed to determine whether there is a relationship between intraoperative tumor consistency and hist...
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Nature Portfolio
2025-01-01
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| author | Eren Yilmaz Seda Duman Ozturk Ayse Uzuner Pinar Yildirim Atakan Emengen Aykut Gokbel Melih Caklili Sibel Balci Ayca Ersen Danyeli Burak Cabuk Ihsan Anik Savas Ceylan |
| author_facet | Eren Yilmaz Seda Duman Ozturk Ayse Uzuner Pinar Yildirim Atakan Emengen Aykut Gokbel Melih Caklili Sibel Balci Ayca Ersen Danyeli Burak Cabuk Ihsan Anik Savas Ceylan |
| author_sort | Eren Yilmaz |
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| description | Abstract The nature of somatotroph adenomas has not been clearly revealed in studies. We consider that there are macroscopic differences in intraoperative tumor consistency in acromegaly patients. We aimed to determine whether there is a relationship between intraoperative tumor consistency and histopathological subtypes by planning a prospective study to determine whether these differences are significant. Between August 1997 and December 2021, 1118 patients with GH-secreting tumors underwent endoscopic endonasal surgery at our Pituitary Research Center. Between January 2022 and May 2023, pure GH-secreting adenomas operated via the endoscopic endonasal approach were sequentially categorized into three types(Type-1:Soft, Type-2:Mucinous/Adhesive, Type-3:Mix/Intermediate) according to the intraoperative tumor consistency. The final patient cohort consisted 218 cases. The ratio of densely granulated adenomas(DG-A) to sparsely granulated adenomas(SG-A) was as follows: Type-1, 89/11; Type-2, 5/95; Type-3, 13/5. Logistic regression revealed that Type-1 tumors were associated with a high remission rate(p = 0.011), and Type-2 were associated with SG-A(p < 0.001). Furthermore, no or weak staining for E-cadherin was associated with Type-2 tumors(p < 0.001). Surgeon could predict the prognosis and histopathological subtype of the pure somatotroph adenoma by observing the intraoperative tumor consistency. This could facilitate better intraoperative planning of patient-specific surgical strategies to increase the remission rates. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e0b5ad206a7445cfaf2bcdd94fe8dd1e2025-01-12T12:16:40ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-85331-5A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patientsEren Yilmaz0Seda Duman Ozturk1Ayse Uzuner2Pinar Yildirim3Atakan Emengen4Aykut Gokbel5Melih Caklili6Sibel Balci7Ayca Ersen Danyeli8Burak Cabuk9Ihsan Anik10Savas Ceylan11Department of Neurosurgery, Cihanbeyli State HospitalDepartment of Pathology, Kocaeli University School of MedicineDepartment of Neurosurgery, Pituitary Research Center, Kocaeli University School of MedicineDepartment of Neurosurgery, Pituitary Research Center, Kocaeli University School of MedicineDepartment of Neurosurgery, Bahcesehir Universty School of MedicineDepartment of Neurosurgery, Bahcesehir Universty School of MedicineDepartment of Neurosurgery, Pituitary Research Center, Kocaeli University School of MedicineDepartment of Biostatistics and Medical Informatics, Kocaeli UniversityDepartment of Pathology, Acibadem UniversityDepartment of Neurosurgery, Pituitary Research Center, Kocaeli University School of MedicineDepartment of Neurosurgery, Pituitary Research Center, Kocaeli University School of MedicineDepartment of Neurosurgery, Bahcesehir Universty School of MedicineAbstract The nature of somatotroph adenomas has not been clearly revealed in studies. We consider that there are macroscopic differences in intraoperative tumor consistency in acromegaly patients. We aimed to determine whether there is a relationship between intraoperative tumor consistency and histopathological subtypes by planning a prospective study to determine whether these differences are significant. Between August 1997 and December 2021, 1118 patients with GH-secreting tumors underwent endoscopic endonasal surgery at our Pituitary Research Center. Between January 2022 and May 2023, pure GH-secreting adenomas operated via the endoscopic endonasal approach were sequentially categorized into three types(Type-1:Soft, Type-2:Mucinous/Adhesive, Type-3:Mix/Intermediate) according to the intraoperative tumor consistency. The final patient cohort consisted 218 cases. The ratio of densely granulated adenomas(DG-A) to sparsely granulated adenomas(SG-A) was as follows: Type-1, 89/11; Type-2, 5/95; Type-3, 13/5. Logistic regression revealed that Type-1 tumors were associated with a high remission rate(p = 0.011), and Type-2 were associated with SG-A(p < 0.001). Furthermore, no or weak staining for E-cadherin was associated with Type-2 tumors(p < 0.001). Surgeon could predict the prognosis and histopathological subtype of the pure somatotroph adenoma by observing the intraoperative tumor consistency. This could facilitate better intraoperative planning of patient-specific surgical strategies to increase the remission rates.https://doi.org/10.1038/s41598-025-85331-5AcromegalyTumor consistencyHistopathological subtypes |
| spellingShingle | Eren Yilmaz Seda Duman Ozturk Ayse Uzuner Pinar Yildirim Atakan Emengen Aykut Gokbel Melih Caklili Sibel Balci Ayca Ersen Danyeli Burak Cabuk Ihsan Anik Savas Ceylan A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients Scientific Reports Acromegaly Tumor consistency Histopathological subtypes |
| title | A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| title_full | A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| title_fullStr | A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| title_full_unstemmed | A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| title_short | A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| title_sort | single center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients |
| topic | Acromegaly Tumor consistency Histopathological subtypes |
| url | https://doi.org/10.1038/s41598-025-85331-5 |
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