Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2

Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2

The serine/threonine kinase CK2 (formerly known as casein kinase II) plays a crucial role in various CNS disorders and is highly expressed in various types of cancer. Therefore, inhibiting this key kinase could be promising for the treatment of these diseases. The CK2 holoenzyme is formed by the rec...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lukas Kröger, Sebastian Borgert, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Molecules
Subjects:	CK2 protein kinase heterotetrameric enzyme protein–protein interaction enzyme inhibition Levy reaction
Online Access:	https://www.mdpi.com/1420-3049/30/1/63
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Downregulation of the keratins CK13 and CK14 does not significantly affect cell viability of human urinary bladder carcinoma cells
by: Anna Scherping, et al.
Published: (2024-10-01)

Identifying the potential of ovalbumin and its’ hydrolysates to be used in a liquid food system to develop functional beverages
by: Maggonage Hasini Udeshika Maggonage, et al.
Published: (2025-01-01)

Expression evaluation of exogenous and endogenous alcohol dehydrogenase genes in transgenic Arabidopsis
by: Haoqiang Yu, et al.
Published: (2025-01-01)

Comparison of the synthesis of the alpha-amylase enzyme by the native strain Bacillus licheniformis in immobilized and immersed cells
by: Fahimeh Mahmoudnia
Published: (2024-12-01)

Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silico structure-activity relationship
by: Jeeraporn Pekkoh, et al.
Published: (2025-06-01)

Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages
by: Małgorzata Orłowska, et al.
Published: (2023-09-01)

Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis
by: Dhoni Akbar Ghozali, et al.
Published: (2024-09-01)

Antioxidant and Renin-Angiotensin System Inhibitory Properties of Cashew Nut and Fluted-Pumpkin Protein Hydrolysates
by: Sunday A. Malomo, et al.
Published: (2020-06-01)

Monitoring of enzymatic cleavage reaction of GST-fusion protein on biolayer interferometry sensor
by: Sena Tarumoto, et al.
Published: (2024-10-01)

Effects of a β-glucan-enriched diet on biomarkers of oxidative stress, energy metabolism and lysosomal function in muscle tissue of European grayling (Thymallus thymallus L.)
by: Kurhaluk Natalia, et al.
Published: (2024-11-01)

Detection of antibodies to non-structural proteins of foot-and-mouth disease virus (review)
by: A. S. Yakovleva, et al.
Published: (2023-09-01)

Evaluation of recombinant proteins <i>T. pallidum</i> Тр0163 and Тр0971 as antigens for the diagnosis of syphilis using enzyme immunoassay
by: Natalia V. Arbuzova, et al.
Published: (2024-12-01)

Influence of Arbuscular Mycorrhizal Fungi on Nitrogen Dynamics During <i>Cinnamomum camphora</i> Litter Decomposition
by: Yuehong Gao, et al.
Published: (2025-01-01)

Development and Application of an Indirect Enzyme‐Linked Immunosorbent Assay Based on a Recombinant Matrix Protein for the Serological Study of Porcine Deltacoronavirus in Mexican Pigs
by: Francisco Jesus Castañeda Montes, et al.
Published: (2024-11-01)

Development and evaluation of the recombinant BP26 protein-based C-ELISA for human brucellosis diagnosis
by: Yujia Xie, et al.
Published: (2025-01-01)

Peptides of Trypsin Hydrolyzate in Bovine Colostrum
by: Sergei L. Tikhonov, et al.
Published: (2023-03-01)

Innovation systems for emerging food technologies: evidence from the development of cultured proteins in Thailand
by: Waverly Eichhorst, et al.
Published: (2025-02-01)

Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways
by: Md. Niaj Morshed, et al.
Published: (2024-12-01)

Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera)
by: Andrea Becchimanzi, et al.
Published: (2025-01-01)

Safety evaluation of the food enzyme protein‐glutamine γ‐glutamyltransferase from the non‐genetically modified Streptomyces mobaraensis strain AE‐BTG
by: EFSA Panel on Food Enzymes (FEZ), et al.
Published: (2024-12-01)

Elucidating the role of compositional and processing variables in tailoring the technological functionalities of plant protein ingredients
by: Lorenzo Barozzi, et al.
Published: (2025-01-01)

An artificial transcription factor that activates potent interferon-γ expression in human Jurkat T Cells
by: Ashley King, et al.
Published: (2025-01-01)

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs
by: Yoonhee Kim, et al.
Published: (2025-01-01)

Editorial: Dietary protein for human health
by: Paul J. Moughan, et al.
Published: (2025-01-01)

Evaluation of Interleukin-23 and Creatine Kinase –MB (CK-MB) Levels in Acute Coronary Syndrome Patients with COVID-19 in Baghdad City
by: Zahraa kareem Yaseen, et al.
Published: (2022-11-01)

Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases
by: Lorena Martínez-Alcantar, et al.
Published: (2024-12-01)

Carbon footprint of alternative protein sources for Atlantic salmon (Salmo salar) aquaculture: A two-step systematic literature review
by: Javier Cantillo, et al.
Published: (2025-03-01)

Assessing the Causal Effect of Circulating Protein‐To‐Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma
by: Qiuyuan Yue, et al.
Published: (2025-01-01)

An integrated approach using proximity labelling and chemical crosslinking to probe in situ host-virus protein–protein interactions
by: Jiaqi Li, et al.
Published: (2024-01-01)

DEVELOPMENT AND VALIDATION OF 3AB-ELISATEST-SYSTEM FOR DETECTION OF ANTIBODIES TO FMD VIRUS NONSTRUCTURAL PROTEINS IN BLOOD SERA FROM CATTLE AND SMALL RUMINANTS
by: A. S. Yakovleva, et al.
Published: (2018-04-01)

Advance technologies for DNA-protein interactions and future research prospect
by: Chengyi Qu, et al.
Published: (2025-02-01)

Benchmarking protein language models for protein crystallization
by: Raghvendra Mall, et al.
Published: (2025-01-01)

Gd-EOB-DTPA增强MRI预测肝细胞癌CK19表达
by: 陈玉莹
Published: (2019-01-01)

EquiRank: Improved protein-protein interface quality estimation using protein language-model-informed equivariant graph neural networks
by: Md Hossain Shuvo, et al.
Published: (2025-01-01)

Stapled peptides: targeting protein-protein interactions in drug development
by: Qian Zhang, et al.
Published: (2024-04-01)

Continuous and Discrete Similarity Coefficient for Identifying Essential Proteins Using Gene Expression Data
by: Jiancheng Zhong, et al.
Published: (2023-06-01)

PIPENN-EMB ensemble net and protein embeddings generalise protein interface prediction beyond homology
by: David P. G. Thomas, et al.
Published: (2025-02-01)

Modification of hempseed protein isolate using a novel two-stage method applying high-pressure homogenization coupled with high-intensity ultrasound
by: Ruyu Zhang, et al.
Published: (2025-01-01)

Evaluation of Machinability and Energy Consumption of CK45 Steel Using Synthetic-Based Nanofluid and Minimum Quantity Lubrication Cutting Fluid
by: Emine Şap, et al.
Published: (2025-01-01)

Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases
by: Magdalena Klink, et al.
Published: (2003-01-01)