Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise
Abstract Maximal oxygen uptake (VO2max) in healthy subjects is primarily limited by systemic oxygen delivery. In chronic kidney disease (CKD), VO2max is potentially reduced by both central and peripheral factors. We aimed to investigate the effect on VO2peak of adding arm exercise to leg exercise. T...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70200 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527545615351808 |
|---|---|
| author | Helena Wallin Eva Jansson Ragad Said Sigrid Lundberg Pourya Zolfaghardidani Maria J. Eriksson Anette Rickenlund Patrik Sundblad |
| author_facet | Helena Wallin Eva Jansson Ragad Said Sigrid Lundberg Pourya Zolfaghardidani Maria J. Eriksson Anette Rickenlund Patrik Sundblad |
| author_sort | Helena Wallin |
| collection | DOAJ |
| description | Abstract Maximal oxygen uptake (VO2max) in healthy subjects is primarily limited by systemic oxygen delivery. In chronic kidney disease (CKD), VO2max is potentially reduced by both central and peripheral factors. We aimed to investigate the effect on VO2peak of adding arm exercise to leg exercise. Ten individuals with CKD stages 3–5 and 10 healthy controls, matched for age, sex, body size, and physical activity level, were included. Subjects performed two maximal exercise tests, one with legs only (L exercise) and one test where arm exercise was added to leg exercise (LA exercise). The increase in VO2peak, when comparing LA exercise with L exercise, was significantly higher in CKD (0.20 ± 0.18 L/min or 2.31 ± 1.78 mL/(kg·min)) than in controls (0.019 ± 0.12 L/min or 0.26 ± 1.62 mL/(kg·min); p = 0.02 and 0.01, respectively). The decrease in peak leg workload, when comparing L exercise with LA exercise, was larger in controls than in CKD, in absolute terms (p = 0.002) and relative to body weight (p = 0.01). VO2max in individuals with CKD is dependent on the active muscle mass, supporting a peripheral limitation to VO2max in CKD. By contrast, the control group appeared to have a more central limitation to VO2max. |
| format | Article |
| id | doaj-art-e0a0d8fd85934574a843289a9f82d1a5 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-e0a0d8fd85934574a843289a9f82d1a52025-01-15T13:36:32ZengWileyPhysiological Reports2051-817X2025-01-01131n/an/a10.14814/phy2.70200Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exerciseHelena Wallin0Eva Jansson1Ragad Said2Sigrid Lundberg3Pourya Zolfaghardidani4Maria J. Eriksson5Anette Rickenlund6Patrik Sundblad7Division of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Stockholm SwedenDivision of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Stockholm SwedenDepartment of Clinical Physiology Karolinska University Hospital Stockholm SwedenNephrology Clinic Danderyds Hospital Stockholm SwedenDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet Stockholm SwedenDepartment of Clinical Physiology Karolinska University Hospital Stockholm SwedenDepartment of Clinical Physiology Karolinska University Hospital Stockholm SwedenDivision of Clinical Physiology Department of Laboratory Medicine Karolinska Institutet Stockholm SwedenAbstract Maximal oxygen uptake (VO2max) in healthy subjects is primarily limited by systemic oxygen delivery. In chronic kidney disease (CKD), VO2max is potentially reduced by both central and peripheral factors. We aimed to investigate the effect on VO2peak of adding arm exercise to leg exercise. Ten individuals with CKD stages 3–5 and 10 healthy controls, matched for age, sex, body size, and physical activity level, were included. Subjects performed two maximal exercise tests, one with legs only (L exercise) and one test where arm exercise was added to leg exercise (LA exercise). The increase in VO2peak, when comparing LA exercise with L exercise, was significantly higher in CKD (0.20 ± 0.18 L/min or 2.31 ± 1.78 mL/(kg·min)) than in controls (0.019 ± 0.12 L/min or 0.26 ± 1.62 mL/(kg·min); p = 0.02 and 0.01, respectively). The decrease in peak leg workload, when comparing L exercise with LA exercise, was larger in controls than in CKD, in absolute terms (p = 0.002) and relative to body weight (p = 0.01). VO2max in individuals with CKD is dependent on the active muscle mass, supporting a peripheral limitation to VO2max in CKD. By contrast, the control group appeared to have a more central limitation to VO2max.https://doi.org/10.14814/phy2.70200arm exerciseexercise capacityexercise limitationkidney disease |
| spellingShingle | Helena Wallin Eva Jansson Ragad Said Sigrid Lundberg Pourya Zolfaghardidani Maria J. Eriksson Anette Rickenlund Patrik Sundblad Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise Physiological Reports arm exercise exercise capacity exercise limitation kidney disease |
| title | Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise |
| title_full | Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise |
| title_fullStr | Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise |
| title_full_unstemmed | Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise |
| title_short | Exercise limitation in chronic kidney disease: An experimental pilot study with leg and arm exercise |
| title_sort | exercise limitation in chronic kidney disease an experimental pilot study with leg and arm exercise |
| topic | arm exercise exercise capacity exercise limitation kidney disease |
| url | https://doi.org/10.14814/phy2.70200 |
| work_keys_str_mv | AT helenawallin exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT evajansson exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT ragadsaid exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT sigridlundberg exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT pouryazolfaghardidani exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT mariajeriksson exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT anetterickenlund exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise AT patriksundblad exerciselimitationinchronickidneydiseaseanexperimentalpilotstudywithlegandarmexercise |