Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis
Diphenhydramine (DPH), a commonly used over-the-counter (OTC) antihistamine and sedative, requires accurate and reliable analytical methods to be evaluated in various matrices. The systematic review provides a comprehensive analysis of the current analytical techniques to detect DPH in biological sa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Forensic Science and Medicine |
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| Online Access: | https://journals.lww.com/10.4103/jfsm.jfsm_133_23 |
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| author | Alphonsa Tom Tina Sharma Mahipal Singh Sankhla Archana Gautam |
| author_facet | Alphonsa Tom Tina Sharma Mahipal Singh Sankhla Archana Gautam |
| author_sort | Alphonsa Tom |
| collection | DOAJ |
| description | Diphenhydramine (DPH), a commonly used over-the-counter (OTC) antihistamine and sedative, requires accurate and reliable analytical methods to be evaluated in various matrices. The systematic review provides a comprehensive analysis of the current analytical techniques to detect DPH in biological samples and pharmaceutical formulations between 2012 and 2022. Case reports of DPH-related fatalities and intoxications were included along with crime statistics of OTC drug seizure in India from 2017 to 2021. The review also points out gaps in the body of knowledge and recommends areas for future study to provide novel and reliable analytical techniques for detecting DPH. Researchers, analysts, and regulatory bodies engaged in toxicology, drug analysis, and pharmaceutical quality control will find this review’s conclusions helpful. |
| format | Article |
| id | doaj-art-e051e1ac8e4242659174e3682d358403 |
| institution | Kabale University |
| issn | 2349-5014 2455-0094 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Forensic Science and Medicine |
| spelling | doaj-art-e051e1ac8e4242659174e3682d3584032025-01-11T10:19:22ZengWolters Kluwer Medknow PublicationsJournal of Forensic Science and Medicine2349-50142455-00942024-12-0110432833610.4103/jfsm.jfsm_133_23Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic AnalysisAlphonsa TomTina SharmaMahipal Singh SankhlaArchana GautamDiphenhydramine (DPH), a commonly used over-the-counter (OTC) antihistamine and sedative, requires accurate and reliable analytical methods to be evaluated in various matrices. The systematic review provides a comprehensive analysis of the current analytical techniques to detect DPH in biological samples and pharmaceutical formulations between 2012 and 2022. Case reports of DPH-related fatalities and intoxications were included along with crime statistics of OTC drug seizure in India from 2017 to 2021. The review also points out gaps in the body of knowledge and recommends areas for future study to provide novel and reliable analytical techniques for detecting DPH. Researchers, analysts, and regulatory bodies engaged in toxicology, drug analysis, and pharmaceutical quality control will find this review’s conclusions helpful.https://journals.lww.com/10.4103/jfsm.jfsm_133_23detection techniquesdiphenhydramine over-the-counterdiphenhydramine case studiesdiphenhydramine forensic analysisdrug abuseover-the-counter abuse |
| spellingShingle | Alphonsa Tom Tina Sharma Mahipal Singh Sankhla Archana Gautam Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis Journal of Forensic Science and Medicine detection techniques diphenhydramine over-the-counter diphenhydramine case studies diphenhydramine forensic analysis drug abuse over-the-counter abuse |
| title | Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis |
| title_full | Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis |
| title_fullStr | Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis |
| title_full_unstemmed | Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis |
| title_short | Comprehensive Review of Analytical Approaches for the Detection of Diphenhydramine: A Systematic Analysis |
| title_sort | comprehensive review of analytical approaches for the detection of diphenhydramine a systematic analysis |
| topic | detection techniques diphenhydramine over-the-counter diphenhydramine case studies diphenhydramine forensic analysis drug abuse over-the-counter abuse |
| url | https://journals.lww.com/10.4103/jfsm.jfsm_133_23 |
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