Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions
Abstract Purpose To assess the repeatability of a microperimetry methodology for quantifying visual function changes in the junctional zone of eyes with geographic atrophy (GA) in the clinical trial context. Methods A post hoc analysis of the OAKS phase III trial was conducted, which enrolled patien...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-024-00624-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544472030085120 |
|---|---|
| author | A. Yasin Alibhai Eric M. Moult Muhammad Usman Jamil Khadija Raza Marco U. Morales Ramiro Ribeiro Caroline R. Baumal James G. Fujimoto Nadia K. Waheed |
| author_facet | A. Yasin Alibhai Eric M. Moult Muhammad Usman Jamil Khadija Raza Marco U. Morales Ramiro Ribeiro Caroline R. Baumal James G. Fujimoto Nadia K. Waheed |
| author_sort | A. Yasin Alibhai |
| collection | DOAJ |
| description | Abstract Purpose To assess the repeatability of a microperimetry methodology for quantifying visual function changes in the junctional zone of eyes with geographic atrophy (GA) in the clinical trial context. Methods A post hoc analysis of the OAKS phase III trial was conducted, which enrolled patients with GA secondary to age-related macular degeneration. Microperimetry using a standard 10 − 2 fovea centered grid was performed at baseline and follow-up visits. GA regions were traced on fundus autofluorescence (FAF) images. Two graders independently registered baseline microperimetry images with baseline FAF images in a sampling of 30 eyes from the OAKS study. Agreement between the two graders’ assessments of mean sensitivity and the number of scotomatous points within a ± 250 𝜇m GA junctional zone was assessed. Results The intraclass correlation (ICC) and coefficient of repeatability (CoR) for the mean junctional zone sensitivity were 0.987 and 0.214 dB, respectively. The ICC and CoR for the total number of scotomatous points within the junctional zone were 0.991 and 1.42, respectively. Conclusions The repeatability of the methodology and its compatibility with standard MP acquisitions appear to make it well-suited for identifying and analyzing retinal sensitivity within high-risk areas of the retina. Summary We present a microperimetry-based methodology for assessing visual function changes in the junctional zone of geographic atrophy lesions using a standard 10 − 2 fovea centered grid in a clinical trial context. The approach’s repeatability and compatibility with standard microperimetry grids may make it useful for assessing the effects of GA therapeutics. |
| format | Article |
| id | doaj-art-e04cfec20734498ea9d5319cb0c9df40 |
| institution | Kabale University |
| issn | 2056-9920 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj-art-e04cfec20734498ea9d5319cb0c9df402025-01-12T12:34:15ZengBMCInternational Journal of Retina and Vitreous2056-99202025-01-011111810.1186/s40942-024-00624-7Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesionsA. Yasin Alibhai0Eric M. Moult1Muhammad Usman Jamil2Khadija Raza3Marco U. Morales4Ramiro Ribeiro5Caroline R. Baumal6James G. Fujimoto7Nadia K. Waheed8Boston Image Reading CenterDepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of TechnologyNew England Eye Center, Tufts Medical Center, Tufts University School of MedicineNew England Eye Center, Tufts Medical Center, Tufts University School of MedicineApellis PharmaceuticalsApellis PharmaceuticalsApellis PharmaceuticalsDepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of TechnologyNew England Eye Center, Tufts Medical Center, Tufts University School of MedicineAbstract Purpose To assess the repeatability of a microperimetry methodology for quantifying visual function changes in the junctional zone of eyes with geographic atrophy (GA) in the clinical trial context. Methods A post hoc analysis of the OAKS phase III trial was conducted, which enrolled patients with GA secondary to age-related macular degeneration. Microperimetry using a standard 10 − 2 fovea centered grid was performed at baseline and follow-up visits. GA regions were traced on fundus autofluorescence (FAF) images. Two graders independently registered baseline microperimetry images with baseline FAF images in a sampling of 30 eyes from the OAKS study. Agreement between the two graders’ assessments of mean sensitivity and the number of scotomatous points within a ± 250 𝜇m GA junctional zone was assessed. Results The intraclass correlation (ICC) and coefficient of repeatability (CoR) for the mean junctional zone sensitivity were 0.987 and 0.214 dB, respectively. The ICC and CoR for the total number of scotomatous points within the junctional zone were 0.991 and 1.42, respectively. Conclusions The repeatability of the methodology and its compatibility with standard MP acquisitions appear to make it well-suited for identifying and analyzing retinal sensitivity within high-risk areas of the retina. Summary We present a microperimetry-based methodology for assessing visual function changes in the junctional zone of geographic atrophy lesions using a standard 10 − 2 fovea centered grid in a clinical trial context. The approach’s repeatability and compatibility with standard microperimetry grids may make it useful for assessing the effects of GA therapeutics.https://doi.org/10.1186/s40942-024-00624-7MicroperimetryGeographic atrophyFundus auto fluorescenceAge-related macular degenerationScotomatous points |
| spellingShingle | A. Yasin Alibhai Eric M. Moult Muhammad Usman Jamil Khadija Raza Marco U. Morales Ramiro Ribeiro Caroline R. Baumal James G. Fujimoto Nadia K. Waheed Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions International Journal of Retina and Vitreous Microperimetry Geographic atrophy Fundus auto fluorescence Age-related macular degeneration Scotomatous points |
| title | Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| title_full | Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| title_fullStr | Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| title_full_unstemmed | Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| title_short | Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| title_sort | evaluating the reliability of a microperimetry based method for assessing visual function in the junctional zone of geographic atrophy lesions |
| topic | Microperimetry Geographic atrophy Fundus auto fluorescence Age-related macular degeneration Scotomatous points |
| url | https://doi.org/10.1186/s40942-024-00624-7 |
| work_keys_str_mv | AT ayasinalibhai evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT ericmmoult evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT muhammadusmanjamil evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT khadijaraza evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT marcoumorales evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT ramiroribeiro evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT carolinerbaumal evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT jamesgfujimoto evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions AT nadiakwaheed evaluatingthereliabilityofamicroperimetrybasedmethodforassessingvisualfunctioninthejunctionalzoneofgeographicatrophylesions |