The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms
Alzheimer’s disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc,...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-01-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/the-importance-of-iron-copper-zinc-and-magnesium-dyshomeostasis-in-terms-of-alzheimers-disease-and-possible-mechanisms/doi/gmj.galenos.2023.3865 |
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| author | Esra Tekin Ayşegül Küçük Mustafa Arslan |
| author_facet | Esra Tekin Ayşegül Küçük Mustafa Arslan |
| author_sort | Esra Tekin |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc, and magnesium vary and their metabolism are impaired in patients with AD. Metal cation dyshomeostasis is believed to be one of the mechanisms that contribute to the development of AD. In this review, we aimed to evaluate various metal cations in terms of AD. |
| format | Article |
| id | doaj-art-e03b29a1c5384c42872fd7703dd92f69 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-e03b29a1c5384c42872fd7703dd92f692025-01-17T12:18:12ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-01-0135110010510.12996/gmj.galenos.2023.3865The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible MechanismsEsra Tekin0https://orcid.org/0000-0002-9684-3277Ayşegül Küçük1https://orcid.org/0000-0001-9316-9574Mustafa Arslan2https://orcid.org/0000-0003-4882-5063Kütahya Health Sciences University Faculty of Medicine, Department of Physiology, Kütahya, TürkiyeKütahya Health Sciences University Faculty of Medicine, Department of Physiology, Kütahya, TürkiyeGazi University Faculty of Medicine Department of Anesthesiology and Reanimation, Ankara, TürkiyeAlzheimer’s disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc, and magnesium vary and their metabolism are impaired in patients with AD. Metal cation dyshomeostasis is believed to be one of the mechanisms that contribute to the development of AD. In this review, we aimed to evaluate various metal cations in terms of AD.https://gazimedj.com/articles/the-importance-of-iron-copper-zinc-and-magnesium-dyshomeostasis-in-terms-of-alzheimers-disease-and-possible-mechanisms/doi/gmj.galenos.2023.3865alzheimer’s diseasedyshomeostasisironcopperzincmagnesium |
| spellingShingle | Esra Tekin Ayşegül Küçük Mustafa Arslan The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms Gazi Medical Journal alzheimer’s disease dyshomeostasis iron copper zinc magnesium |
| title | The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms |
| title_full | The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms |
| title_fullStr | The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms |
| title_full_unstemmed | The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms |
| title_short | The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms |
| title_sort | importance of iron copper zinc and magnesium dyshomeostasis in terms of alzheimer s disease and possible mechanisms |
| topic | alzheimer’s disease dyshomeostasis iron copper zinc magnesium |
| url | https://gazimedj.com/articles/the-importance-of-iron-copper-zinc-and-magnesium-dyshomeostasis-in-terms-of-alzheimers-disease-and-possible-mechanisms/doi/gmj.galenos.2023.3865 |
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