Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures
Objective: We present a physics-based, temperature and state-dependent electrical conductivity model for soft biological tissue under thermal therapies with a quantified damage parameter that represents the state of soft biological tissue (degree of denaturation). Most existing models consider elect...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2422509 |
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| author | Junren Ran Martin Ostoja-Starzewski |
| author_facet | Junren Ran Martin Ostoja-Starzewski |
| author_sort | Junren Ran |
| collection | DOAJ |
| description | Objective: We present a physics-based, temperature and state-dependent electrical conductivity model for soft biological tissue under thermal therapies with a quantified damage parameter that represents the state of soft biological tissue (degree of denaturation). Most existing models consider electrical conductivity to be only temperature-dependent and evaluate tissue damage during post-processing after temperature calculation. Our model allows tissue damage to be coupled into the thermal model for a more accurate description of both RF ablation and electrosurgery. Methods: We model the denaturation process with an Arrhenius-type differential equation for chemical kinetics and a modified Stogryn equation for electrical conductivity under state transition. We present experimental data from two types of heating procedures at 128 kHz to validate and showcase the capability of our model. Results: Our model is able to capture the change in electrical conductivity during heating, cooling, and reheating procedures, which distinguishes different states and shows the irreversibility of denaturation. The model also accurately captures tissue change during slow cooking at a constant temperature, highlighting a state dependence. Conclusion: By incorporating state dependence into the model for electrical properties, we are able to capture the denaturation process more accurately and distinguish different degrees of damage. Our model allows the modeling of procedures involving repeated heating or cooling, which is impossible for models without a state dependence. While being able to adapt to patient-specific needs, the model can be used to improve planning and control in future robot-assisted surgeries to reduce unnecessary damage. |
| format | Article |
| id | doaj-art-e03903fc57e14a8a810980a70f3a267c |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-e03903fc57e14a8a810980a70f3a267c2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2422509Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperaturesJunren Ran0Martin Ostoja-Starzewski1Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USADepartment of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USAObjective: We present a physics-based, temperature and state-dependent electrical conductivity model for soft biological tissue under thermal therapies with a quantified damage parameter that represents the state of soft biological tissue (degree of denaturation). Most existing models consider electrical conductivity to be only temperature-dependent and evaluate tissue damage during post-processing after temperature calculation. Our model allows tissue damage to be coupled into the thermal model for a more accurate description of both RF ablation and electrosurgery. Methods: We model the denaturation process with an Arrhenius-type differential equation for chemical kinetics and a modified Stogryn equation for electrical conductivity under state transition. We present experimental data from two types of heating procedures at 128 kHz to validate and showcase the capability of our model. Results: Our model is able to capture the change in electrical conductivity during heating, cooling, and reheating procedures, which distinguishes different states and shows the irreversibility of denaturation. The model also accurately captures tissue change during slow cooking at a constant temperature, highlighting a state dependence. Conclusion: By incorporating state dependence into the model for electrical properties, we are able to capture the denaturation process more accurately and distinguish different degrees of damage. Our model allows the modeling of procedures involving repeated heating or cooling, which is impossible for models without a state dependence. While being able to adapt to patient-specific needs, the model can be used to improve planning and control in future robot-assisted surgeries to reduce unnecessary damage.https://www.tandfonline.com/doi/10.1080/02656736.2024.2422509Electrosurgeryradiofrequency ablationionic heatingtissue propertieshyperthermia |
| spellingShingle | Junren Ran Martin Ostoja-Starzewski Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures International Journal of Hyperthermia Electrosurgery radiofrequency ablation ionic heating tissue properties hyperthermia |
| title | Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| title_full | Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| title_fullStr | Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| title_full_unstemmed | Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| title_short | Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| title_sort | temperature and state dependent electrical conductivity of soft biological tissue at hyperthermic temperatures |
| topic | Electrosurgery radiofrequency ablation ionic heating tissue properties hyperthermia |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2422509 |
| work_keys_str_mv | AT junrenran temperatureandstatedependentelectricalconductivityofsoftbiologicaltissueathyperthermictemperatures AT martinostojastarzewski temperatureandstatedependentelectricalconductivityofsoftbiologicaltissueathyperthermictemperatures |