Establishing a causal link between the human papilloma virus and oral fibromas
Fibroma, a benign tumour of fibrous connective tissue, can be seen as a reactive connective tissue hyperplasia in response to trauma and irritation. They typically have a firm consistency, are nodular and asymptomatic, have a colour that is similar to the mucosa, a sessile base, a smooth surface, an...
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| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000037 |
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| author | Gargi Sarode Urmi Ghone Renuka Gophane Nidhi Kumari Sachin C. Sarode |
| author_facet | Gargi Sarode Urmi Ghone Renuka Gophane Nidhi Kumari Sachin C. Sarode |
| author_sort | Gargi Sarode |
| collection | DOAJ |
| description | Fibroma, a benign tumour of fibrous connective tissue, can be seen as a reactive connective tissue hyperplasia in response to trauma and irritation. They typically have a firm consistency, are nodular and asymptomatic, have a colour that is similar to the mucosa, a sessile base, a smooth surface, and are situated in the buccal mucosa along the line of occlusion, tongue, and lip mucosa. We retrospectively investigated total 79 cases and intriguingly, 41 cases were not associated with any history or clinical evidence of chronic trauma of dental origin suggesting different pathogenesis mechanism. Out of 79 cases of oral fibroma, 18 showed evidence of koilocytes in the overlying epithelium with 14 cases not associated with history of any trauma. This might suggest the cause and effect relationship between HPV and oral fibromas, however, the possibility of secondary infection in already existing fibroma can be considered. This intriguing finding prompt us to propose a novel hypothesis explaining the role of human papilloma virus in the pathogenesis of fibroma. |
| format | Article |
| id | doaj-art-e0221cde08504d629188306eb2b6bc3a |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-e0221cde08504d629188306eb2b6bc3a2025-01-09T06:15:10ZengElsevierOral Oncology Reports2772-90602024-03-019100157Establishing a causal link between the human papilloma virus and oral fibromasGargi Sarode0Urmi Ghone1Renuka Gophane2Nidhi Kumari3Sachin C. Sarode4Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr.D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr.D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr.D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr.D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr.D. Y. Patil Vidyapeeth, Pimpri, Pune, 411018, India; Dr. D. Y. Patil Unitech Society's Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, 411018, Maharashtra, India; Corresponding author. Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 18, Maharashtra, India.Fibroma, a benign tumour of fibrous connective tissue, can be seen as a reactive connective tissue hyperplasia in response to trauma and irritation. They typically have a firm consistency, are nodular and asymptomatic, have a colour that is similar to the mucosa, a sessile base, a smooth surface, and are situated in the buccal mucosa along the line of occlusion, tongue, and lip mucosa. We retrospectively investigated total 79 cases and intriguingly, 41 cases were not associated with any history or clinical evidence of chronic trauma of dental origin suggesting different pathogenesis mechanism. Out of 79 cases of oral fibroma, 18 showed evidence of koilocytes in the overlying epithelium with 14 cases not associated with history of any trauma. This might suggest the cause and effect relationship between HPV and oral fibromas, however, the possibility of secondary infection in already existing fibroma can be considered. This intriguing finding prompt us to propose a novel hypothesis explaining the role of human papilloma virus in the pathogenesis of fibroma.http://www.sciencedirect.com/science/article/pii/S2772906024000037FibromaHPVPathogenesisOral pathology |
| spellingShingle | Gargi Sarode Urmi Ghone Renuka Gophane Nidhi Kumari Sachin C. Sarode Establishing a causal link between the human papilloma virus and oral fibromas Oral Oncology Reports Fibroma HPV Pathogenesis Oral pathology |
| title | Establishing a causal link between the human papilloma virus and oral fibromas |
| title_full | Establishing a causal link between the human papilloma virus and oral fibromas |
| title_fullStr | Establishing a causal link between the human papilloma virus and oral fibromas |
| title_full_unstemmed | Establishing a causal link between the human papilloma virus and oral fibromas |
| title_short | Establishing a causal link between the human papilloma virus and oral fibromas |
| title_sort | establishing a causal link between the human papilloma virus and oral fibromas |
| topic | Fibroma HPV Pathogenesis Oral pathology |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000037 |
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