Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy
ABSTRACT Background: Patients with chronic Chagas cardiomyopathy (CCC) may present with fatigue and dyspnea, which contribute to functional impairment. However, simple and inexpensive methods for evaluation of functional impairment and identification of left ventricular (LV) systolic dysfunction i...
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Sociedade Brasileira de Medicina Tropical (SBMT)
2025-08-01
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| author | Lucas Frois Fernandes Oliveira Matheus Ribeiro Ávila Whesley Tanor Silva Sueli Ferreira da Fonseca Endi Lanza Galvão Cheyenne Alves Fonseca Vanessa Amaral Mendonça Ana Cristina Rodrigues Lacerda Sabrina Pinheiro Tsopanoglou Sanny Cristina de Castro Faria Daniel Menezes de Souza Mauro Felippe Felix Mediano Marcus Alessandro de Alcantara Pedro Henrique Scheidt Figueiredo Manoel Otávio da Costa Rocha Henrique Silveira Costa |
| author_facet | Lucas Frois Fernandes Oliveira Matheus Ribeiro Ávila Whesley Tanor Silva Sueli Ferreira da Fonseca Endi Lanza Galvão Cheyenne Alves Fonseca Vanessa Amaral Mendonça Ana Cristina Rodrigues Lacerda Sabrina Pinheiro Tsopanoglou Sanny Cristina de Castro Faria Daniel Menezes de Souza Mauro Felippe Felix Mediano Marcus Alessandro de Alcantara Pedro Henrique Scheidt Figueiredo Manoel Otávio da Costa Rocha Henrique Silveira Costa |
| author_sort | Lucas Frois Fernandes Oliveira |
| collection | DOAJ |
| description | ABSTRACT Background: Patients with chronic Chagas cardiomyopathy (CCC) may present with fatigue and dyspnea, which contribute to functional impairment. However, simple and inexpensive methods for evaluation of functional impairment and identification of left ventricular (LV) systolic dysfunction in patients with CCC are lacking. The Human Activity Profile (HAP) has potential in functional evaluation of patients with CCC. This study was conducted to analyze the association between HAP, functional parameters, and LV systolic dysfunction in patients with CCC, and to demonstrate the accuracy of HAP in identifying LV systolic dysfunction in patients with CCC. Methods: One hundred and twenty-six patients with CCC (NYHA I-III, 18.9% with LV systolic dysfunction) were evaluated using echocardiography, the 60-second sit-to-stand test (STS60, for lower limb strength and endurance), and the HAP questionnaire. In addition, the gait speed and handgrip strength of each patient was measured. Results: HAP score was correlated with gait speed (r=-0.206; p=0.023), STS60 score (r=0.199, p=0.030), and handgrip strength (r=0.315, p<0.01). Binary logistic regression showed that HAP score was the only functional variable associated with LV systolic dysfunction. Patients with LV systolic dysfunction (n=24) had lower HAP scores than those without LV systolic dysfunction (n=102) (p <0.01). The area under the ROC curve indicated that HAP score had an acceptable discriminatory ability to identify LV systolic dysfunction in patients with CCC (AUC=0.713). The optimal cut-off HAP score for identifying these patients was <56 points. Conclusion: HAP score is associated with LV systolic dysfunction in patients with CCC. |
| format | Article |
| id | doaj-art-e0046b80c0f0487f94865a7defefcb21 |
| institution | Kabale University |
| issn | 1678-9849 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj-art-e0046b80c0f0487f94865a7defefcb212025-08-20T03:41:27ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492025-08-015810.1590/0037-8682-0251-2024Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathyLucas Frois Fernandes Oliveirahttps://orcid.org/0000-0002-1942-2567Matheus Ribeiro Ávilahttps://orcid.org/0000-0002-9331-4521Whesley Tanor Silvahttps://orcid.org/0000-0002-5783-1820Sueli Ferreira da Fonsecahttps://orcid.org/0000-0001-8020-8511Endi Lanza Galvãohttps://orcid.org/0000-0002-5648-3932Cheyenne Alves Fonsecahttps://orcid.org/0009-0001-8191-8459Vanessa Amaral Mendonçahttps://orcid.org/0000-0002-1696-6091Ana Cristina Rodrigues Lacerdahttps://orcid.org/0000-0001-5366-3754Sabrina Pinheiro Tsopanoglouhttps://orcid.org/0000-0002-1942-5848Sanny Cristina de Castro Fariahttps://orcid.org/0009-0008-6113-7576Daniel Menezes de Souzahttps://orcid.org/0000-0002-6804-4320Mauro Felippe Felix Medianohttps://orcid.org/0000-0001-6369-3631Marcus Alessandro de Alcantarahttps://orcid.org/0000-0001-9233-0186Pedro Henrique Scheidt Figueiredohttps://orcid.org/0000-0002-6748-3081Manoel Otávio da Costa Rochahttps://orcid.org/0000-0002-4721-1767Henrique Silveira Costahttps://orcid.org/0000-0002-1426-7246ABSTRACT Background: Patients with chronic Chagas cardiomyopathy (CCC) may present with fatigue and dyspnea, which contribute to functional impairment. However, simple and inexpensive methods for evaluation of functional impairment and identification of left ventricular (LV) systolic dysfunction in patients with CCC are lacking. The Human Activity Profile (HAP) has potential in functional evaluation of patients with CCC. This study was conducted to analyze the association between HAP, functional parameters, and LV systolic dysfunction in patients with CCC, and to demonstrate the accuracy of HAP in identifying LV systolic dysfunction in patients with CCC. Methods: One hundred and twenty-six patients with CCC (NYHA I-III, 18.9% with LV systolic dysfunction) were evaluated using echocardiography, the 60-second sit-to-stand test (STS60, for lower limb strength and endurance), and the HAP questionnaire. In addition, the gait speed and handgrip strength of each patient was measured. Results: HAP score was correlated with gait speed (r=-0.206; p=0.023), STS60 score (r=0.199, p=0.030), and handgrip strength (r=0.315, p<0.01). Binary logistic regression showed that HAP score was the only functional variable associated with LV systolic dysfunction. Patients with LV systolic dysfunction (n=24) had lower HAP scores than those without LV systolic dysfunction (n=102) (p <0.01). The area under the ROC curve indicated that HAP score had an acceptable discriminatory ability to identify LV systolic dysfunction in patients with CCC (AUC=0.713). The optimal cut-off HAP score for identifying these patients was <56 points. Conclusion: HAP score is associated with LV systolic dysfunction in patients with CCC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100408&tlng=enChagas diseaseChagas cardiomyopathyExerciseActivities of daily livingHuman activities |
| spellingShingle | Lucas Frois Fernandes Oliveira Matheus Ribeiro Ávila Whesley Tanor Silva Sueli Ferreira da Fonseca Endi Lanza Galvão Cheyenne Alves Fonseca Vanessa Amaral Mendonça Ana Cristina Rodrigues Lacerda Sabrina Pinheiro Tsopanoglou Sanny Cristina de Castro Faria Daniel Menezes de Souza Mauro Felippe Felix Mediano Marcus Alessandro de Alcantara Pedro Henrique Scheidt Figueiredo Manoel Otávio da Costa Rocha Henrique Silveira Costa Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Chagas cardiomyopathy Exercise Activities of daily living Human activities |
| title | Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy |
| title_full | Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy |
| title_fullStr | Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy |
| title_full_unstemmed | Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy |
| title_short | Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy |
| title_sort | human activity profile questionnaire functional assessment and screening for systolic dysfunction in patients with chagas cardiomyopathy |
| topic | Chagas disease Chagas cardiomyopathy Exercise Activities of daily living Human activities |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100408&tlng=en |
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