Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy

Human Activity Profile Questionnaire: functional assessment and screening for systolic dysfunction in patients with Chagas cardiomyopathy

ABSTRACT Background: Patients with chronic Chagas cardiomyopathy (CCC) may present with fatigue and dyspnea, which contribute to functional impairment. However, simple and inexpensive methods for evaluation of functional impairment and identification of left ventricular (LV) systolic dysfunction i...

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Main Authors: Lucas Frois Fernandes Oliveira, Matheus Ribeiro Ávila, Whesley Tanor Silva, Sueli Ferreira da Fonseca, Endi Lanza Galvão, Cheyenne Alves Fonseca, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda, Sabrina Pinheiro Tsopanoglou, Sanny Cristina de Castro Faria, Daniel Menezes de Souza, Mauro Felippe Felix Mediano, Marcus Alessandro de Alcantara, Pedro Henrique Scheidt Figueiredo, Manoel Otávio da Costa Rocha, Henrique Silveira Costa
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2025-08-01
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Chagas disease
Chagas cardiomyopathy
Exercise
Activities of daily living
Human activities
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822025000100408&tlng=en
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Summary:ABSTRACT Background: Patients with chronic Chagas cardiomyopathy (CCC) may present with fatigue and dyspnea, which contribute to functional impairment. However, simple and inexpensive methods for evaluation of functional impairment and identification of left ventricular (LV) systolic dysfunction in patients with CCC are lacking. The Human Activity Profile (HAP) has potential in functional evaluation of patients with CCC. This study was conducted to analyze the association between HAP, functional parameters, and LV systolic dysfunction in patients with CCC, and to demonstrate the accuracy of HAP in identifying LV systolic dysfunction in patients with CCC. Methods: One hundred and twenty-six patients with CCC (NYHA I-III, 18.9% with LV systolic dysfunction) were evaluated using echocardiography, the 60-second sit-to-stand test (STS60, for lower limb strength and endurance), and the HAP questionnaire. In addition, the gait speed and handgrip strength of each patient was measured. Results: HAP score was correlated with gait speed (r=-0.206; p=0.023), STS60 score (r=0.199, p=0.030), and handgrip strength (r=0.315, p<0.01). Binary logistic regression showed that HAP score was the only functional variable associated with LV systolic dysfunction. Patients with LV systolic dysfunction (n=24) had lower HAP scores than those without LV systolic dysfunction (n=102) (p <0.01). The area under the ROC curve indicated that HAP score had an acceptable discriminatory ability to identify LV systolic dysfunction in patients with CCC (AUC=0.713). The optimal cut-off HAP score for identifying these patients was <56 points. Conclusion: HAP score is associated with LV systolic dysfunction in patients with CCC.
ISSN:1678-9849

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