Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota
Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect of human evolution, plays a crucial role in this condition....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Pharmaceutical Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2024.2351946 |
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| author | Xia-Qing Wu Lei Zhao Yan-Long Zhao Xin-Yao He Liang Zou Ying-Yong Zhao Xia Li |
| author_facet | Xia-Qing Wu Lei Zhao Yan-Long Zhao Xin-Yao He Liang Zou Ying-Yong Zhao Xia Li |
| author_sort | Xia-Qing Wu |
| collection | DOAJ |
| description | Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect of human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes in ameliorating DKD by addressing the gut microbiota.Objective This review elucidates the modifications in gut microbiota observed in DKD and explores the impact of TCM interventions on correcting microbial dysregulation.Methods We searched relevant articles from databases including Web of Science, PubMed, ScienceDirect, Wiley, and Springer Nature. The following keywords were used: diabetic kidney disease, diabetic nephropathy, gut microbiota, natural product, TCM, Chinese herbal medicine, and Chinese medicinal herbs. Rigorous criteria were applied to identify high-quality studies on TCM interventions against DKD.Results Dysregulation of the gut microbiota, including Lactobacillus, Streptococcus, and Clostridium, has been observed in individuals with DKD. Key indicators of microbial dysregulation include increased uremic solutes and decreased short-chain fatty acids. Various TCM therapies, such as formulas, tablets, granules, capsules, and decoctions, exhibit unique advantages in regulating the disordered microbiota to treat DKD.Conclusion This review highlights the importance of targeting the gut-kidney axis to regulate microbial disorders, their metabolites, and associated signaling pathways in DKD. The Qing-Re-Xiao-Zheng formula, the Shenyan Kangfu tablet, the Huangkui capsule, and the Bekhogainsam decoction are potential candidates to address the gut-kidney axis. TCM interventions offer a significant therapeutic approach by targeting microbial dysregulation in patients with DKD. |
| format | Article |
| id | doaj-art-dffa9b791f86462cb7e72491c125877c |
| institution | Kabale University |
| issn | 1388-0209 1744-5116 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj-art-dffa9b791f86462cb7e72491c125877c2024-12-09T07:41:45ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162024-12-0162142343510.1080/13880209.2024.2351946Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiotaXia-Qing Wu0Lei Zhao1Yan-Long Zhao2Xin-Yao He3Liang Zou4Ying-Yong Zhao5Xia Li6Faculty of Life Science & Medicine, Northwest University, Xi’an, Shaanxi, ChinaDepartment of General Practice, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaFaculty of Life Science & Medicine, Northwest University, Xi’an, Shaanxi, ChinaFaculty of Life Science & Medicine, Northwest University, Xi’an, Shaanxi, ChinaSchool of Food and Bioengineering, Chengdu University, Chengdu, Sichuan, ChinaFaculty of Life Science & Medicine, Northwest University, Xi’an, Shaanxi, ChinaFaculty of Life Science & Medicine, Northwest University, Xi’an, Shaanxi, ChinaContext Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect of human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes in ameliorating DKD by addressing the gut microbiota.Objective This review elucidates the modifications in gut microbiota observed in DKD and explores the impact of TCM interventions on correcting microbial dysregulation.Methods We searched relevant articles from databases including Web of Science, PubMed, ScienceDirect, Wiley, and Springer Nature. The following keywords were used: diabetic kidney disease, diabetic nephropathy, gut microbiota, natural product, TCM, Chinese herbal medicine, and Chinese medicinal herbs. Rigorous criteria were applied to identify high-quality studies on TCM interventions against DKD.Results Dysregulation of the gut microbiota, including Lactobacillus, Streptococcus, and Clostridium, has been observed in individuals with DKD. Key indicators of microbial dysregulation include increased uremic solutes and decreased short-chain fatty acids. Various TCM therapies, such as formulas, tablets, granules, capsules, and decoctions, exhibit unique advantages in regulating the disordered microbiota to treat DKD.Conclusion This review highlights the importance of targeting the gut-kidney axis to regulate microbial disorders, their metabolites, and associated signaling pathways in DKD. The Qing-Re-Xiao-Zheng formula, the Shenyan Kangfu tablet, the Huangkui capsule, and the Bekhogainsam decoction are potential candidates to address the gut-kidney axis. TCM interventions offer a significant therapeutic approach by targeting microbial dysregulation in patients with DKD.https://www.tandfonline.com/doi/10.1080/13880209.2024.2351946Chronic kidney diseaseintestinal epithelial cell barrier |
| spellingShingle | Xia-Qing Wu Lei Zhao Yan-Long Zhao Xin-Yao He Liang Zou Ying-Yong Zhao Xia Li Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota Pharmaceutical Biology Chronic kidney disease intestinal epithelial cell barrier |
| title | Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| title_full | Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| title_fullStr | Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| title_full_unstemmed | Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| title_short | Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| title_sort | traditional chinese medicine improved diabetic kidney disease through targeting gut microbiota |
| topic | Chronic kidney disease intestinal epithelial cell barrier |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2024.2351946 |
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