Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study
Context: Breast cancer (BC) is the most common cancer in women. Reports suggest a possible relationship between lipids and BC; but the pattern of lipid profile in breast lesions is unknown. Objective: to evaluate the lipid profile of women with BC and compare with benign breast lesions and contr...
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| Format: | Article |
| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2025-01-01
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| Series: | Ibom Medical Journal |
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| Online Access: | http://ibommedicaljournal.org/index.php/imjhome/article/view/606 |
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| author | Ajeigbe AK Omisore AD Akinde AO Makinde RA Ajose OA |
| author_facet | Ajeigbe AK Omisore AD Akinde AO Makinde RA Ajose OA |
| author_sort | Ajeigbe AK |
| collection | DOAJ |
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Context: Breast cancer (BC) is the most common cancer in women. Reports suggest a possible relationship between lipids and BC; but the pattern of lipid profile in breast lesions is unknown.
Objective: to evaluate the lipid profile of women with BC and compare with benign breast lesions and controls.
Study design: Women (107) undergoing breast imaging in Ile-Ife were enrolled for this pilot study and stratified into BC, benign breast lesion (BBL), and controls. Information was obtained by a structured proforma followed by anthropometric measurements and the collection of blood for lipid assays (Total cholesterol [TC], triglyceride [TG], and high-density lipoprotein cholesterol [HDLc]) done on an autoanalyzer. Very low-density lipoprotein cholesterol (VLDLc) and Low-density lipoprotein cholesterol [LDLc] were calculated using the Friedewald equation. Mean serum concentrations of lipids were considered as normal, low, or high using standard cutoff. Data was analyzed by SPSS 22 using ANOVA. P < 0.05 was considered significant.
Results: Women with BC were significantly younger (51.6±10. 3 vs 62.5±9.5 and 59.0±12.7 years), and had significantly lower mean TG (1.1±0.4 vs 1.5±0.7 and 1.4±0.5 mmol/L), VLDLc (0.51±0.19 Vs 0.69±0.32 and 0.62±0.25 mmol/L) and HDLc (1.1±0.4 vs 1.4±0.3 and 1.5±0.3 mmol/L) than BBL and controls respectively. P < 0.05 However, women with BBL had significantly higher mean TC (6.0 ±1.2 vs 4.8±1.1 and 5.2±1.1 mmol/L), LDL-c (3.9±1.3 vs 3.2 ±0.9 and 3.2±1.0 mmol/L) respectively. P < 0.05
Conclusions: The BC group had hypoalphalipoproteinaemia while the BBL group had hypercholesterolemia. The dyslipidemia in BC is an independent cardiovascular risk factor.
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| format | Article |
| id | doaj-art-dff1736efc6740d09d876e0be9bec1ff |
| institution | Kabale University |
| issn | 1597-7188 2735-9964 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj-art-dff1736efc6740d09d876e0be9bec1ff2025-01-12T11:36:04ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642025-01-0118110.61386/imj.v18i1.606Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot StudyAjeigbe AK0Omisore AD1Akinde AO2Makinde RA3Ajose OA4Department of Chemical Pathology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals, Ile-Ife, NigeriaDepartment of Radiology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals, Ile-Ife, NigeriaDepartment of Radiology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, NigeriaDepartment of Chemical Pathology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals, Ile-Ife, NigeriaDepartment of Chemical Pathology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals, Ile-Ife, Nigeria Context: Breast cancer (BC) is the most common cancer in women. Reports suggest a possible relationship between lipids and BC; but the pattern of lipid profile in breast lesions is unknown. Objective: to evaluate the lipid profile of women with BC and compare with benign breast lesions and controls. Study design: Women (107) undergoing breast imaging in Ile-Ife were enrolled for this pilot study and stratified into BC, benign breast lesion (BBL), and controls. Information was obtained by a structured proforma followed by anthropometric measurements and the collection of blood for lipid assays (Total cholesterol [TC], triglyceride [TG], and high-density lipoprotein cholesterol [HDLc]) done on an autoanalyzer. Very low-density lipoprotein cholesterol (VLDLc) and Low-density lipoprotein cholesterol [LDLc] were calculated using the Friedewald equation. Mean serum concentrations of lipids were considered as normal, low, or high using standard cutoff. Data was analyzed by SPSS 22 using ANOVA. P < 0.05 was considered significant. Results: Women with BC were significantly younger (51.6±10. 3 vs 62.5±9.5 and 59.0±12.7 years), and had significantly lower mean TG (1.1±0.4 vs 1.5±0.7 and 1.4±0.5 mmol/L), VLDLc (0.51±0.19 Vs 0.69±0.32 and 0.62±0.25 mmol/L) and HDLc (1.1±0.4 vs 1.4±0.3 and 1.5±0.3 mmol/L) than BBL and controls respectively. P < 0.05 However, women with BBL had significantly higher mean TC (6.0 ±1.2 vs 4.8±1.1 and 5.2±1.1 mmol/L), LDL-c (3.9±1.3 vs 3.2 ±0.9 and 3.2±1.0 mmol/L) respectively. P < 0.05 Conclusions: The BC group had hypoalphalipoproteinaemia while the BBL group had hypercholesterolemia. The dyslipidemia in BC is an independent cardiovascular risk factor. http://ibommedicaljournal.org/index.php/imjhome/article/view/606Breast cancerLipidWomen |
| spellingShingle | Ajeigbe AK Omisore AD Akinde AO Makinde RA Ajose OA Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study Ibom Medical Journal Breast cancer Lipid Women |
| title | Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study |
| title_full | Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study |
| title_fullStr | Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study |
| title_full_unstemmed | Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study |
| title_short | Assessment of Lipid Profile among Women with Malignant and Non-malignant Breast Lesions in a Tertiary Hospital, Nigeria: A Pilot Study |
| title_sort | assessment of lipid profile among women with malignant and non malignant breast lesions in a tertiary hospital nigeria a pilot study |
| topic | Breast cancer Lipid Women |
| url | http://ibommedicaljournal.org/index.php/imjhome/article/view/606 |
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