Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation
Abstract Spinal manipulative therapy (SMT) has been shown to significantly alleviate pain in patients with lumbar disc herniation (LDH), with its effects closely associated with brain function modulation. This study investigates the neural biomarkers linked to pain relief efficacy following a comple...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81126-2 |
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| author | Xing-chen Zhou Shuang Wu Kai-zheng Wang Long-hao Chen Shuang-wei Hong Yu Tian Hui-jie Hu Jia Lin Zi-cheng Wei Yun-xing Xie Zi-hui Yin Zhi-zhen Lv Li-jiang Lv |
| author_facet | Xing-chen Zhou Shuang Wu Kai-zheng Wang Long-hao Chen Shuang-wei Hong Yu Tian Hui-jie Hu Jia Lin Zi-cheng Wei Yun-xing Xie Zi-hui Yin Zhi-zhen Lv Li-jiang Lv |
| author_sort | Xing-chen Zhou |
| collection | DOAJ |
| description | Abstract Spinal manipulative therapy (SMT) has been shown to significantly alleviate pain in patients with lumbar disc herniation (LDH), with its effects closely associated with brain function modulation. This study investigates the neural biomarkers linked to pain relief efficacy following a complete SMT treatment cycle in LDH patients. A total of 59 LDH patients were randomized into two groups: SMT treatment (Group 1, n = 28) and sham treatment (ST) (Group 2, n = 31). A matched healthy control group (Group 3, n = 28) was also included. Functional magnetic resonance imaging (fMRI) was performed on LDH patients at two time points (TPs)—before (TP1) and after (TP2) treatment—while healthy controls were scanned once. Clinical assessments were conducted using the Visual Analogue Scale (VAS) and the Japanese Orthopaedic Association (JOA) scale. Post-treatment results indicated significant improvements in both VAS and JOA scores for Group 1, while the improvement was limited to VAS scores for Group 2. Graph properties analysis revealed notable differences in brain network connectivity between LDH patients and healthy controls, particularly between the left precentral gyrus (left PreCG) and left inferior frontal gyrus, opercular part (left IFGoperc). Enhanced functional connectivity (FC) was observed in Group 1, notably between the right angular gyrus (right ANG) and the left middle orbital gyrus (left ORBmid), with right ANG showing a significant positive correlation with clinical scores. This study identifies the sensorimotor network—salience network are significantly activated in chronic pain among LDH patients. The default mode network—dorsal attention network may serve as key neural biomarkers for the efficacy of SMT treatment in alleviating pain in LDH. |
| format | Article |
| id | doaj-art-dfe7c7ece2e1491c9cb1e04e7df9f588 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-dfe7c7ece2e1491c9cb1e04e7df9f5882024-12-01T12:26:32ZengNature PortfolioScientific Reports2045-23222024-11-0114111510.1038/s41598-024-81126-2Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniationXing-chen Zhou0Shuang Wu1Kai-zheng Wang2Long-hao Chen3Shuang-wei Hong4Yu Tian5Hui-jie Hu6Jia Lin7Zi-cheng Wei8Yun-xing Xie9Zi-hui Yin10Zhi-zhen Lv11Li-jiang Lv12The Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)The Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineThe Third Affiliated Hospital of Zhejiang University of Traditional Chinese MedicineAbstract Spinal manipulative therapy (SMT) has been shown to significantly alleviate pain in patients with lumbar disc herniation (LDH), with its effects closely associated with brain function modulation. This study investigates the neural biomarkers linked to pain relief efficacy following a complete SMT treatment cycle in LDH patients. A total of 59 LDH patients were randomized into two groups: SMT treatment (Group 1, n = 28) and sham treatment (ST) (Group 2, n = 31). A matched healthy control group (Group 3, n = 28) was also included. Functional magnetic resonance imaging (fMRI) was performed on LDH patients at two time points (TPs)—before (TP1) and after (TP2) treatment—while healthy controls were scanned once. Clinical assessments were conducted using the Visual Analogue Scale (VAS) and the Japanese Orthopaedic Association (JOA) scale. Post-treatment results indicated significant improvements in both VAS and JOA scores for Group 1, while the improvement was limited to VAS scores for Group 2. Graph properties analysis revealed notable differences in brain network connectivity between LDH patients and healthy controls, particularly between the left precentral gyrus (left PreCG) and left inferior frontal gyrus, opercular part (left IFGoperc). Enhanced functional connectivity (FC) was observed in Group 1, notably between the right angular gyrus (right ANG) and the left middle orbital gyrus (left ORBmid), with right ANG showing a significant positive correlation with clinical scores. This study identifies the sensorimotor network—salience network are significantly activated in chronic pain among LDH patients. The default mode network—dorsal attention network may serve as key neural biomarkers for the efficacy of SMT treatment in alleviating pain in LDH.https://doi.org/10.1038/s41598-024-81126-2Functional magnetic resonance imagingLumbar disc herniationSpinal manipulative therapyGraph properties |
| spellingShingle | Xing-chen Zhou Shuang Wu Kai-zheng Wang Long-hao Chen Shuang-wei Hong Yu Tian Hui-jie Hu Jia Lin Zi-cheng Wei Yun-xing Xie Zi-hui Yin Zhi-zhen Lv Li-jiang Lv Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation Scientific Reports Functional magnetic resonance imaging Lumbar disc herniation Spinal manipulative therapy Graph properties |
| title | Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| title_full | Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| title_fullStr | Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| title_full_unstemmed | Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| title_short | Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| title_sort | default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation |
| topic | Functional magnetic resonance imaging Lumbar disc herniation Spinal manipulative therapy Graph properties |
| url | https://doi.org/10.1038/s41598-024-81126-2 |
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