Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI
<b>Aim:</b> This study aims to determine the morphological and morphometric differences of the corpus callosum in terms of sex using high-resolution images obtained from formalin-fixed sheep brains by 3T Magnetic Resonance Imaging (MRI).<p> <b>Materials and Methods:</b>...
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| Language: | English |
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Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1368 |
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| author | Sedat Aydoğdu Emrullah Eken Mustafa Koplay |
| author_facet | Sedat Aydoğdu Emrullah Eken Mustafa Koplay |
| author_sort | Sedat Aydoğdu |
| collection | DOAJ |
| description | <b>Aim:</b> This study aims to determine the morphological and morphometric differences
of the corpus callosum in terms of sex using high-resolution images
obtained from formalin-fixed sheep brains by 3T Magnetic Resonance Imaging
(MRI).<p>
<b>Materials and Methods:</b> In the study, a total of 18 adult healthy Akkaraman
sheep brains (9 females and 9 males), which had no anomaly and were fixed
with formaldehyde, were used. Morphometric measurements in sheep brains
were performed on T2-weighted images obtained from 3T MRI. First, the
midsagittal cross-sectional area of the corpus callosum was calculated using
MIMICS. Before morphometric measurements, images were converted from
DICOM format to NIfTI format in the MRcronGL. Then, the normalization of
the images were performed using the standard template in the ITK-SNAP. After
that images were opened in the ITK-SNAP, and morphometric measurements
were performed in genu corporis callosi, truncus corporis callosi, and splenium
corporis callosi.<p>
<b>Results: </b>In sheep, the lower surface of the truncus corporis callosi, which
forms the roof of the ventriculus lateralis, was more concave than dog and cat,
and flatter than human, horse and rabbit. There was no sexual dimorphism
in corpus callosum length, midsagittal corpus callosum cross-sectional area,
genu corporis callosi width, truncus corporis callosi width and splenium corporis
callosi width. Similarly, no sexual dimorphism was observed in the ratio
between midsagittal corpus callosum cross-sectional area and brain weight
and volume. However, it was observed that the ratio between surface area and
volume was very close to the difference frequently encountered in this parameter
in studies conducted in humans and other mammals.<p>
<b>Conclusion:</b> It is thought that the findings obtained from healthy sheep brains
in this study can be used in neurodegenerative disease models created in sheep
in neuroscience studies and experimental studies. |
| format | Article |
| id | doaj-art-dfdb183ca84a4c34b8a5b66a1483817e |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-dfdb183ca84a4c34b8a5b66a1483817e2025-01-02T22:35:53ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-12-013742252341368Sexual dimorphism in the sheep corpus callosum using 3 tesla MRISedat Aydoğdu0Emrullah Eken1Mustafa Koplay2Selcuk University, Veterinary Faculty, Department of Anatomy, Konya, TurkeySelcuk University, Veterinary Faculty, Department of Anatomy, Konya, TurkeySelcuk University, Medicine Faculty, Department of Radiology Konya, Turkey<b>Aim:</b> This study aims to determine the morphological and morphometric differences of the corpus callosum in terms of sex using high-resolution images obtained from formalin-fixed sheep brains by 3T Magnetic Resonance Imaging (MRI).<p> <b>Materials and Methods:</b> In the study, a total of 18 adult healthy Akkaraman sheep brains (9 females and 9 males), which had no anomaly and were fixed with formaldehyde, were used. Morphometric measurements in sheep brains were performed on T2-weighted images obtained from 3T MRI. First, the midsagittal cross-sectional area of the corpus callosum was calculated using MIMICS. Before morphometric measurements, images were converted from DICOM format to NIfTI format in the MRcronGL. Then, the normalization of the images were performed using the standard template in the ITK-SNAP. After that images were opened in the ITK-SNAP, and morphometric measurements were performed in genu corporis callosi, truncus corporis callosi, and splenium corporis callosi.<p> <b>Results: </b>In sheep, the lower surface of the truncus corporis callosi, which forms the roof of the ventriculus lateralis, was more concave than dog and cat, and flatter than human, horse and rabbit. There was no sexual dimorphism in corpus callosum length, midsagittal corpus callosum cross-sectional area, genu corporis callosi width, truncus corporis callosi width and splenium corporis callosi width. Similarly, no sexual dimorphism was observed in the ratio between midsagittal corpus callosum cross-sectional area and brain weight and volume. However, it was observed that the ratio between surface area and volume was very close to the difference frequently encountered in this parameter in studies conducted in humans and other mammals.<p> <b>Conclusion:</b> It is thought that the findings obtained from healthy sheep brains in this study can be used in neurodegenerative disease models created in sheep in neuroscience studies and experimental studies.http://eurasianjvetsci.org/pdf.php3?id=1368braincorpus callosumsheepmagnetic resonance imaging |
| spellingShingle | Sedat Aydoğdu Emrullah Eken Mustafa Koplay Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI Eurasian Journal of Veterinary Sciences brain corpus callosum sheep magnetic resonance imaging |
| title | Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI |
| title_full | Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI |
| title_fullStr | Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI |
| title_full_unstemmed | Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI |
| title_short | Sexual dimorphism in the sheep corpus callosum using 3 tesla MRI |
| title_sort | sexual dimorphism in the sheep corpus callosum using 3 tesla mri |
| topic | brain corpus callosum sheep magnetic resonance imaging |
| url | http://eurasianjvetsci.org/pdf.php3?id=1368 |
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