A systematic review on gut microbiota in type 2 diabetes mellitus
Aims/hypothesisThe gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis of biological agents, development of the immune system, and maintenance of gastrointestinal integrity. Gut dysbiosis is thought to be associated with type 2 diabetes mellitus (T2DM), one of...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1486793/full |
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| author | Serena Chong Serena Chong Mike Lin Mike Lin Deborah Chong Slade Jensen Slade Jensen Slade Jensen Namson S. Lau Namson S. Lau Namson S. Lau |
| author_facet | Serena Chong Serena Chong Mike Lin Mike Lin Deborah Chong Slade Jensen Slade Jensen Slade Jensen Namson S. Lau Namson S. Lau Namson S. Lau |
| author_sort | Serena Chong |
| collection | DOAJ |
| description | Aims/hypothesisThe gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis of biological agents, development of the immune system, and maintenance of gastrointestinal integrity. Gut dysbiosis is thought to be associated with type 2 diabetes mellitus (T2DM), one of the world’s fastest growing diseases. The aim of this systematic review is to identify differences in the composition and diversity of the gut microbiota in individuals with T2DM.MethodsA systematic search was conducted to identify studies reporting on the difference in gut microbiota composition between individuals with T2DM and healthy controls. Relevant studies were evaluated, and their characteristics and results were extracted using a standardized data extraction form. The studies were assessed for risk of bias and their findings were reported narratively.Results58 observational studies published between 2010 and 2024 were included. Beta diversity was commonly reported to be different between individuals with T2DM and healthy individuals. Genera Lactobacillus, Escherichia-Shigella, Enterococcus, Subdoligranulum and Fusobacteria were found to be positively associated; while Akkermansia, Bifidobacterium, Bacteroides, Roseburia, Faecalibacteirum and Prevotella were found to be negatively associated with T2DM.ConclusionsThis systematic review demonstrates a strong association between T2DM and gut dysbiosis, as evidenced by differential microbial abundances and altered diversity indices. Among these taxa, Escherichia-Shigella is consistently associated with T2DM, whereas Faecalibacterium prausnitzii appears to offer a protective effect against T2DM. However, the heterogeneity and observational nature of these studies preclude the establishment of causative relationships. Future research should incorporate age, diet and medication-matched controls, and include functional analysis of these gut microbes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023459937. |
| format | Article |
| id | doaj-art-dfd68da577b24d10a43f452e28a4a850 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-dfd68da577b24d10a43f452e28a4a8502025-01-17T05:10:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14867931486793A systematic review on gut microbiota in type 2 diabetes mellitusSerena Chong0Serena Chong1Mike Lin2Mike Lin3Deborah Chong4Slade Jensen5Slade Jensen6Slade Jensen7Namson S. Lau8Namson S. Lau9Namson S. Lau10South West Sydney Limb Preservation and Wound Research, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaSouth West Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, AustraliaDepartment of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, AustraliaGarvan Institute of Research, Sydney, NSW, AustraliaAnimal Health Laboratory, Department of Natural Resources and Environment Tasmania, Tasmania, TAS, AustraliaSouth West Sydney Limb Preservation and Wound Research, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaInfectious Disease and Microbiology, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaSchool of Medicine Antibiotic Resistance and Mobile Elements Groups, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaSouth West Sydney Limb Preservation and Wound Research, Ingham Institute for Applied Medical Research, Sydney, NSW, AustraliaSouth West Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, AustraliaLiverpool Diabetes Collaboration, Ingham Institute of Applied Medical Research, Sydney, NSW, AustraliaAims/hypothesisThe gut microbiota play crucial roles in the digestion and degradation of nutrients, synthesis of biological agents, development of the immune system, and maintenance of gastrointestinal integrity. Gut dysbiosis is thought to be associated with type 2 diabetes mellitus (T2DM), one of the world’s fastest growing diseases. The aim of this systematic review is to identify differences in the composition and diversity of the gut microbiota in individuals with T2DM.MethodsA systematic search was conducted to identify studies reporting on the difference in gut microbiota composition between individuals with T2DM and healthy controls. Relevant studies were evaluated, and their characteristics and results were extracted using a standardized data extraction form. The studies were assessed for risk of bias and their findings were reported narratively.Results58 observational studies published between 2010 and 2024 were included. Beta diversity was commonly reported to be different between individuals with T2DM and healthy individuals. Genera Lactobacillus, Escherichia-Shigella, Enterococcus, Subdoligranulum and Fusobacteria were found to be positively associated; while Akkermansia, Bifidobacterium, Bacteroides, Roseburia, Faecalibacteirum and Prevotella were found to be negatively associated with T2DM.ConclusionsThis systematic review demonstrates a strong association between T2DM and gut dysbiosis, as evidenced by differential microbial abundances and altered diversity indices. Among these taxa, Escherichia-Shigella is consistently associated with T2DM, whereas Faecalibacterium prausnitzii appears to offer a protective effect against T2DM. However, the heterogeneity and observational nature of these studies preclude the establishment of causative relationships. Future research should incorporate age, diet and medication-matched controls, and include functional analysis of these gut microbes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023459937.https://www.frontiersin.org/articles/10.3389/fendo.2024.1486793/fullgut microbiotadiabetesgut dysbiosisdiabetes mellitussystematic review |
| spellingShingle | Serena Chong Serena Chong Mike Lin Mike Lin Deborah Chong Slade Jensen Slade Jensen Slade Jensen Namson S. Lau Namson S. Lau Namson S. Lau A systematic review on gut microbiota in type 2 diabetes mellitus Frontiers in Endocrinology gut microbiota diabetes gut dysbiosis diabetes mellitus systematic review |
| title | A systematic review on gut microbiota in type 2 diabetes mellitus |
| title_full | A systematic review on gut microbiota in type 2 diabetes mellitus |
| title_fullStr | A systematic review on gut microbiota in type 2 diabetes mellitus |
| title_full_unstemmed | A systematic review on gut microbiota in type 2 diabetes mellitus |
| title_short | A systematic review on gut microbiota in type 2 diabetes mellitus |
| title_sort | systematic review on gut microbiota in type 2 diabetes mellitus |
| topic | gut microbiota diabetes gut dysbiosis diabetes mellitus systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1486793/full |
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