Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator

In this paper, a fractional model in the Caputo sense is used to characterize the dynamics of HPV with cervical cancer. Generalized mean value theorem has been used to examine whether the infection model has a unique positive solution. The model has two equilibrium points: the disease-free point and...

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Main Authors: Bushra Bajjah, Mahmut Modanli
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Discrete Dynamics in Nature and Society
Online Access:http://dx.doi.org/10.1155/2024/2580745
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author Bushra Bajjah
Mahmut Modanli
author_facet Bushra Bajjah
Mahmut Modanli
author_sort Bushra Bajjah
collection DOAJ
description In this paper, a fractional model in the Caputo sense is used to characterize the dynamics of HPV with cervical cancer. Generalized mean value theorem has been used to examine whether the infection model has a unique positive solution. The model has two equilibrium points: the disease-free point and the endemic point. The examination of the system’s local and global stability is provided in terms of the basic reproductive number Rp°. The global stability analysis has been carried out using an appropriate Lyapunov function and the LaSalle invariant principle. The results demonstrate that in the infection model, if Rp°<1, then the solution converges to the disease-free equilibrium, which is both locally and globally asymptotically stable. Whilst Rp°>1, the endemic equilibrium is considered to exist. Simulations are implemented via a finite difference method with Grünwald-Letnikov discretization approach for Caputo derivative operator to define how changes in parameters impact the dynamic behavior of the system using Matlab.
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spelling doaj-art-dfcea414db0142e9b91f32c8201a592d2025-02-03T07:23:23ZengWileyDiscrete Dynamics in Nature and Society1607-887X2024-01-01202410.1155/2024/2580745Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo OperatorBushra Bajjah0Mahmut Modanli1Thamar UniversityHarran UniversityIn this paper, a fractional model in the Caputo sense is used to characterize the dynamics of HPV with cervical cancer. Generalized mean value theorem has been used to examine whether the infection model has a unique positive solution. The model has two equilibrium points: the disease-free point and the endemic point. The examination of the system’s local and global stability is provided in terms of the basic reproductive number Rp°. The global stability analysis has been carried out using an appropriate Lyapunov function and the LaSalle invariant principle. The results demonstrate that in the infection model, if Rp°<1, then the solution converges to the disease-free equilibrium, which is both locally and globally asymptotically stable. Whilst Rp°>1, the endemic equilibrium is considered to exist. Simulations are implemented via a finite difference method with Grünwald-Letnikov discretization approach for Caputo derivative operator to define how changes in parameters impact the dynamic behavior of the system using Matlab.http://dx.doi.org/10.1155/2024/2580745
spellingShingle Bushra Bajjah
Mahmut Modanli
Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
Discrete Dynamics in Nature and Society
title Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
title_full Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
title_fullStr Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
title_full_unstemmed Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
title_short Finite Difference Method for Infection Model of HPV with Cervical Cancer under Caputo Operator
title_sort finite difference method for infection model of hpv with cervical cancer under caputo operator
url http://dx.doi.org/10.1155/2024/2580745
work_keys_str_mv AT bushrabajjah finitedifferencemethodforinfectionmodelofhpvwithcervicalcancerundercaputooperator
AT mahmutmodanli finitedifferencemethodforinfectionmodelofhpvwithcervicalcancerundercaputooperator