The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities?
The innate immune response is the body's first line of defense against external pathogens and endogenous damage signals. The cGAS-STING pathway is a crucial component of the innate immune response, playing a key role in initiating antiviral and anti-infective immune responses by recognizing cyt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1471287/full |
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| author | Jun Hu Mengxiang Tian |
| author_facet | Jun Hu Mengxiang Tian |
| author_sort | Jun Hu |
| collection | DOAJ |
| description | The innate immune response is the body's first line of defense against external pathogens and endogenous damage signals. The cGAS-STING pathway is a crucial component of the innate immune response, playing a key role in initiating antiviral and anti-infective immune responses by recognizing cytosolic DNA. Acute cerebral infarction is one of the leading causes of death and disability worldwide, with the primary treatment approach being the restoration of blood flow to ischemic brain tissue. However, reperfusion injury remains a significant challenge during treatment. The overactivation of the cGAS-STING pathway and its association with ischemia-reperfusion injury have been confirmed in numerous studies. This article will systematically elucidate the mechanisms of the cGAS-STING pathway, its role in ischemia-reperfusion injury in acute cerebral infarction, the current research status of cGAS-STING inhibitors, and the application of nanomaterials in this context, evaluating the therapeutic potential of this pathway. |
| format | Article |
| id | doaj-art-dfce2b15645d422e83e95f6f92fe2b20 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-dfce2b15645d422e83e95f6f92fe2b202024-12-17T05:10:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14712871471287The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities?Jun Hu0Mengxiang Tian1Department of Rehabilitation Medicine, The Affiliated Hospital of Yunnan University, Kunming, ChinaDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaThe innate immune response is the body's first line of defense against external pathogens and endogenous damage signals. The cGAS-STING pathway is a crucial component of the innate immune response, playing a key role in initiating antiviral and anti-infective immune responses by recognizing cytosolic DNA. Acute cerebral infarction is one of the leading causes of death and disability worldwide, with the primary treatment approach being the restoration of blood flow to ischemic brain tissue. However, reperfusion injury remains a significant challenge during treatment. The overactivation of the cGAS-STING pathway and its association with ischemia-reperfusion injury have been confirmed in numerous studies. This article will systematically elucidate the mechanisms of the cGAS-STING pathway, its role in ischemia-reperfusion injury in acute cerebral infarction, the current research status of cGAS-STING inhibitors, and the application of nanomaterials in this context, evaluating the therapeutic potential of this pathway.https://www.frontiersin.org/articles/10.3389/fneur.2024.1471287/fullcGAS-STING pathwayacute cerebral infarctionischemia-reperfusioncGAS-STING inhibitorapplication of nanomaterials |
| spellingShingle | Jun Hu Mengxiang Tian The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? Frontiers in Neurology cGAS-STING pathway acute cerebral infarction ischemia-reperfusion cGAS-STING inhibitor application of nanomaterials |
| title | The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? |
| title_full | The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? |
| title_fullStr | The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? |
| title_full_unstemmed | The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? |
| title_short | The cGAS-STING pathway in ischemia-reperfusion injury in acute cerebral infarction: a new therapeutic opportunities? |
| title_sort | cgas sting pathway in ischemia reperfusion injury in acute cerebral infarction a new therapeutic opportunities |
| topic | cGAS-STING pathway acute cerebral infarction ischemia-reperfusion cGAS-STING inhibitor application of nanomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1471287/full |
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