Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol
Introduction Neonatal sepsis, a significant contributor to global neonatal mortality, poses substantial risks to infant health, particularly in low-resource countries like Nepal. Despite its high prevalence, there is a lack of clarity in defining and understanding neonatal sepsis, leading to challen...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/8/1/e002955.full |
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| author | Manu Raj Remya Sudevan Swechhya Vaidya Jayasree Chandramathi Shailendra Bir Karmacharya Kalpana Subedi Ganendra Bhakta Raya Dhruba Shrestha |
| author_facet | Manu Raj Remya Sudevan Swechhya Vaidya Jayasree Chandramathi Shailendra Bir Karmacharya Kalpana Subedi Ganendra Bhakta Raya Dhruba Shrestha |
| author_sort | Manu Raj |
| collection | DOAJ |
| description | Introduction Neonatal sepsis, a significant contributor to global neonatal mortality, poses substantial risks to infant health, particularly in low-resource countries like Nepal. Despite its high prevalence, there is a lack of clarity in defining and understanding neonatal sepsis, leading to challenges in diagnosing and managing the condition effectively. The probable impact of neonatal sepsis on long-term neurodevelopmental outcomes, including motor and cognitive delays, remains under-explored in Nepal. The primary objective of this study is to report the prevalence of neurodevelopmental delay in neonates with documented sepsis. The secondary objective is to report significant associations of the same with selected probable risk factors.Methods and analysis This is a dual-centric prospective cohort study that is ongoing at two hospitals—Paropakar Maternity and Women’s Hospital and Siddhi Memorial Hospital in Nepal, over a 2-year period. Neonates diagnosed with sepsis will be assessed using the Developmental Assessment Scale for Indian Infants at 6 months and 1 year, postdiagnosis. Statistical analyses will include prevalence estimation and logistic regression. |
| format | Article |
| id | doaj-art-dfb5638b020243b984da9d909528d854 |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj-art-dfb5638b020243b984da9d909528d8542024-12-06T07:05:08ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722024-12-018110.1136/bmjpo-2024-002955Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocolManu Raj0Remya Sudevan1Swechhya Vaidya2Jayasree Chandramathi3Shailendra Bir Karmacharya4Kalpana Subedi5Ganendra Bhakta Raya6Dhruba Shrestha7Health Sciences Research, Amrita Institute of Medical Sciences, Kochi, Kerala, IndiaDepartments of Health Sciences Research & Cardiology, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, IndiaHealth Science Research, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, IndiaDivision of Neonatology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, IndiaNeonatology, Paropakar Maternity and Women`s Hospital, Kathmandu, NepalNeonatology, Paropakar Maternity and Women`s Hospital, Kathmandu, NepalPaediatrics, Siddhi Memorial Foundation, Bhaktapur, Bagmati, NepalPaediatrics, Siddhi Memorial Foundation, Bhaktapur, Bagmati, NepalIntroduction Neonatal sepsis, a significant contributor to global neonatal mortality, poses substantial risks to infant health, particularly in low-resource countries like Nepal. Despite its high prevalence, there is a lack of clarity in defining and understanding neonatal sepsis, leading to challenges in diagnosing and managing the condition effectively. The probable impact of neonatal sepsis on long-term neurodevelopmental outcomes, including motor and cognitive delays, remains under-explored in Nepal. The primary objective of this study is to report the prevalence of neurodevelopmental delay in neonates with documented sepsis. The secondary objective is to report significant associations of the same with selected probable risk factors.Methods and analysis This is a dual-centric prospective cohort study that is ongoing at two hospitals—Paropakar Maternity and Women’s Hospital and Siddhi Memorial Hospital in Nepal, over a 2-year period. Neonates diagnosed with sepsis will be assessed using the Developmental Assessment Scale for Indian Infants at 6 months and 1 year, postdiagnosis. Statistical analyses will include prevalence estimation and logistic regression.https://bmjpaedsopen.bmj.com/content/8/1/e002955.full |
| spellingShingle | Manu Raj Remya Sudevan Swechhya Vaidya Jayasree Chandramathi Shailendra Bir Karmacharya Kalpana Subedi Ganendra Bhakta Raya Dhruba Shrestha Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol BMJ Paediatrics Open |
| title | Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol |
| title_full | Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol |
| title_fullStr | Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol |
| title_full_unstemmed | Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol |
| title_short | Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol |
| title_sort | prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in nepal study protocol |
| url | https://bmjpaedsopen.bmj.com/content/8/1/e002955.full |
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