Households as foci for dengue transmission in highly urban Vietnam.
<h4>Background</h4>Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unc...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-02-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0003528 |
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| author | Katherine L Anders Le Hong Nga Nguyen Thi Van Thuy Tran Van Ngoc Cao Thi Tam Luong Thi Hue Tai Nguyen Thanh Truong Huynh Thi Le Duyen Vu Tuan Trung Duong Thi Hue Kien Marcel Wolbers Bridget Wills Nguyen Van Vinh Chau Nguyen Dac Tho Cameron P Simmons |
| author_facet | Katherine L Anders Le Hong Nga Nguyen Thi Van Thuy Tran Van Ngoc Cao Thi Tam Luong Thi Hue Tai Nguyen Thanh Truong Huynh Thi Le Duyen Vu Tuan Trung Duong Thi Hue Kien Marcel Wolbers Bridget Wills Nguyen Van Vinh Chau Nguyen Dac Tho Cameron P Simmons |
| author_sort | Katherine L Anders |
| collection | DOAJ |
| description | <h4>Background</h4>Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam.<h4>Methods</h4>We enrolled 71 index cases with suspected dengue (subsequently classified as 52 dengue cases and 19 non-dengue controls); each initiated the enrollment of a cluster of 25-35 household members and neighbors who were followed up over 14 days. Incident DENV infections in cluster participants were identified by RT-PCR, NS1-ELISA, and/or DENV-IgM/-IgG seroconversion, and recent infections by DENV-IgM positivity at baseline.<h4>Principal findings/conclusions</h4>There was no excess risk of DENV infection within dengue case clusters during the two-week follow-up, compared to control clusters, but the prevalence of recent DENV infection at baseline was two-fold higher in case clusters than controls (OR 2.3, 95%CI 1.0-5.1, p = 0.05). Prevalence of DENV infection in Aedes aegypti was similar in case and control houses, and low overall (1%). Our findings are broadly consistent with household clustering of dengue risk, but indicate that any clustering is at a short temporal scale rather than sustained chains of localized transmission. This suggests that reactive perifocal insecticide spraying may have a limited impact in this setting. |
| format | Article |
| id | doaj-art-dfa6173b5fa44b68b9f87ee84bd5153d |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-dfa6173b5fa44b68b9f87ee84bd5153d2025-08-20T03:46:23ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352015-02-0192e000352810.1371/journal.pntd.0003528Households as foci for dengue transmission in highly urban Vietnam.Katherine L AndersLe Hong NgaNguyen Thi Van ThuyTran Van NgocCao Thi TamLuong Thi Hue TaiNguyen Thanh TruongHuynh Thi Le DuyenVu Tuan TrungDuong Thi Hue KienMarcel WolbersBridget WillsNguyen Van Vinh ChauNguyen Dac ThoCameron P Simmons<h4>Background</h4>Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam.<h4>Methods</h4>We enrolled 71 index cases with suspected dengue (subsequently classified as 52 dengue cases and 19 non-dengue controls); each initiated the enrollment of a cluster of 25-35 household members and neighbors who were followed up over 14 days. Incident DENV infections in cluster participants were identified by RT-PCR, NS1-ELISA, and/or DENV-IgM/-IgG seroconversion, and recent infections by DENV-IgM positivity at baseline.<h4>Principal findings/conclusions</h4>There was no excess risk of DENV infection within dengue case clusters during the two-week follow-up, compared to control clusters, but the prevalence of recent DENV infection at baseline was two-fold higher in case clusters than controls (OR 2.3, 95%CI 1.0-5.1, p = 0.05). Prevalence of DENV infection in Aedes aegypti was similar in case and control houses, and low overall (1%). Our findings are broadly consistent with household clustering of dengue risk, but indicate that any clustering is at a short temporal scale rather than sustained chains of localized transmission. This suggests that reactive perifocal insecticide spraying may have a limited impact in this setting.https://doi.org/10.1371/journal.pntd.0003528 |
| spellingShingle | Katherine L Anders Le Hong Nga Nguyen Thi Van Thuy Tran Van Ngoc Cao Thi Tam Luong Thi Hue Tai Nguyen Thanh Truong Huynh Thi Le Duyen Vu Tuan Trung Duong Thi Hue Kien Marcel Wolbers Bridget Wills Nguyen Van Vinh Chau Nguyen Dac Tho Cameron P Simmons Households as foci for dengue transmission in highly urban Vietnam. PLoS Neglected Tropical Diseases |
| title | Households as foci for dengue transmission in highly urban Vietnam. |
| title_full | Households as foci for dengue transmission in highly urban Vietnam. |
| title_fullStr | Households as foci for dengue transmission in highly urban Vietnam. |
| title_full_unstemmed | Households as foci for dengue transmission in highly urban Vietnam. |
| title_short | Households as foci for dengue transmission in highly urban Vietnam. |
| title_sort | households as foci for dengue transmission in highly urban vietnam |
| url | https://doi.org/10.1371/journal.pntd.0003528 |
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