Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus
AIMS: The purpose of this study is to determine if heat shock protein 70 (Hsp-70), a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus (GDM) and to determine whether altered serum Hsp-70 concentrations in umbilical...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2024-04-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3579126 |
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| author | Aybike Tazegul Sedat Abuşoğlu Görkem Aktaş Nasuh Utku Doğan Berat Berrin Gençoğlu Bakbak Cetin Celik Ali Unlu Özlem Seçilmiş Ayşegül Kebapçılar Setenay Yılmaz Mete Bertizlioğlu |
| author_facet | Aybike Tazegul Sedat Abuşoğlu Görkem Aktaş Nasuh Utku Doğan Berat Berrin Gençoğlu Bakbak Cetin Celik Ali Unlu Özlem Seçilmiş Ayşegül Kebapçılar Setenay Yılmaz Mete Bertizlioğlu |
| author_sort | Aybike Tazegul |
| collection | DOAJ |
| description | AIMS: The purpose of this study is to determine if heat shock protein 70 (Hsp-70), a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus (GDM) and to determine whether altered serum Hsp-70 concentrations in umbilical cord are related to serve as an indicator of early term delivery (37 0/7–38 6/7 weeks of gestation) in women with GDM and control group.
METHODS: The study included 62 patients with GDM (GDM group) and 22 non-diabetic, healthy women before caesarean section in this case-control study. We analyzed serum levels of Hsp-70 in pregnancies and umbilical cord sera and other biochemical and anthropometric markers, early term delivery in all subjects.
RESULTS: Maternal Serum levels of Hsp-70 were significantly higher in patients with GDM than in healthy pregnant women. The umbilical cord levels of Hsp-70 in GDM patients were also increased as compared to healthy pregnant women but missed the commonly acceptable significance level. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, in women with GDM patients. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, also in the whole group.
CONCLUSIONS: Maternal Hsp-70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp-70 values may potentially be used as indicators of risk factor for early term delivery in pregnancies. |
| format | Article |
| id | doaj-art-df9f63312de949eb8e7cf3dc42149434 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-df9f63312de949eb8e7cf3dc421494342025-01-03T00:46:51ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-04-0134225125710.54005/geneltip.1400341154Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes MellitusAybike Tazegul0Sedat Abuşoğlu1Görkem Aktaş2Nasuh Utku Doğan3Berat Berrin Gençoğlu BakbakCetin Celik4Ali Unlu5Özlem Seçilmiş6Ayşegül KebapçılarSetenay Yılmaz7Mete Bertizlioğlu8SELCUK UNIVERSITYSELCUK UNIVERSITYSAĞLIK BAKANLIĞI KONYA DR. ALİ KEMAL BELVİRANLI KADIN HASTALIKLARI VE DOĞUM HASTANESİAKDENİZ ÜNİVERSİTESİSELCUK UNIVERSITYSELCUK UNIVERSITYSELCUK UNIVERSITYSELCUK UNIVERSITYKONYA ŞEHİR HASTANESİAIMS: The purpose of this study is to determine if heat shock protein 70 (Hsp-70), a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus (GDM) and to determine whether altered serum Hsp-70 concentrations in umbilical cord are related to serve as an indicator of early term delivery (37 0/7–38 6/7 weeks of gestation) in women with GDM and control group. METHODS: The study included 62 patients with GDM (GDM group) and 22 non-diabetic, healthy women before caesarean section in this case-control study. We analyzed serum levels of Hsp-70 in pregnancies and umbilical cord sera and other biochemical and anthropometric markers, early term delivery in all subjects. RESULTS: Maternal Serum levels of Hsp-70 were significantly higher in patients with GDM than in healthy pregnant women. The umbilical cord levels of Hsp-70 in GDM patients were also increased as compared to healthy pregnant women but missed the commonly acceptable significance level. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, in women with GDM patients. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, also in the whole group. CONCLUSIONS: Maternal Hsp-70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp-70 values may potentially be used as indicators of risk factor for early term delivery in pregnancies.https://dergipark.org.tr/tr/download/article-file/3579126heat-shock protein 70gestasyonel diyabetes mellituserken doğumgestational diabetes mellitusheat-shock protein 70preterm birth |
| spellingShingle | Aybike Tazegul Sedat Abuşoğlu Görkem Aktaş Nasuh Utku Doğan Berat Berrin Gençoğlu Bakbak Cetin Celik Ali Unlu Özlem Seçilmiş Ayşegül Kebapçılar Setenay Yılmaz Mete Bertizlioğlu Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus Genel Tıp Dergisi heat-shock protein 70 gestasyonel diyabetes mellitus erken doğum gestational diabetes mellitus heat-shock protein 70 preterm birth |
| title | Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus |
| title_full | Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus |
| title_fullStr | Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus |
| title_full_unstemmed | Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus |
| title_short | Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus |
| title_sort | maternal and umbilical cord heat shock protein 70 levels in patients with gestational diabetes mellitus |
| topic | heat-shock protein 70 gestasyonel diyabetes mellitus erken doğum gestational diabetes mellitus heat-shock protein 70 preterm birth |
| url | https://dergipark.org.tr/tr/download/article-file/3579126 |
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