Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study
Background: Chronic obstructive pulmonary disease (COPD) is a major health concern in India, with exacerbations leading to increased morbidity, mortality, and healthcare costs. Periodontal disease, a chronic inflammatory condition, may affect COPD outcomes by promoting systemic inflammation. This pr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1223_24 |
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| author | Anuj Singh Parihar Dhairaysheel N. Edake Sandhya Nema Manoharmayum Laxmipriya Shailja S. Vediya Deepak Kochar Rashmi Laddha |
| author_facet | Anuj Singh Parihar Dhairaysheel N. Edake Sandhya Nema Manoharmayum Laxmipriya Shailja S. Vediya Deepak Kochar Rashmi Laddha |
| author_sort | Anuj Singh Parihar |
| collection | DOAJ |
| description | Background:
Chronic obstructive pulmonary disease (COPD) is a major health concern in India, with exacerbations leading to increased morbidity, mortality, and healthcare costs. Periodontal disease, a chronic inflammatory condition, may affect COPD outcomes by promoting systemic inflammation. This prospective cohort study aimed to investigate the association between periodontal inflammation and the risk of COPD exacerbations in the Indian population.
Methods:
A total of 2500 participants with established COPD from various regions of India were enrolled and followed for five years. Baseline assessments included comprehensive periodontal evaluations, with measurements of clinical parameters and inflammatory markers (C-reactive protein, interleukin-6). COPD exacerbations were defined as events requiring medical intervention, such as hospitalization, emergency room visits, or changes in medication.
Results:
Periodontal inflammation, measured by clinical attachment loss and elevated inflammatory markers, was significantly associated with a higher risk of COPD exacerbations (Hazard Ratio [HR] 2.3, 95% Confidence Interval [CI] 1.7–3.1), even after adjusting for confounders. Specific periodontal parameters and inflammatory markers were identified as strong predictors of future exacerbations.
Conclusions:
This study provides evidence that periodontal inflammation is an independent and potentially modifiable risk factor for COPD exacerbations in the Indian population. Addressing periodontal health as a part of COPD management may offer a novel approach to reduce the frequency and severity of exacerbations, thereby improving quality of life and clinical outcomes. |
| format | Article |
| id | doaj-art-df97b385641447fa9a86732358566ad7 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-df97b385641447fa9a86732358566ad72025-01-13T10:54:51ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4006S400910.4103/jpbs.jpbs_1223_24Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort StudyAnuj Singh PariharDhairaysheel N. EdakeSandhya NemaManoharmayum LaxmipriyaShailja S. VediyaDeepak KocharRashmi LaddhaBackground: Chronic obstructive pulmonary disease (COPD) is a major health concern in India, with exacerbations leading to increased morbidity, mortality, and healthcare costs. Periodontal disease, a chronic inflammatory condition, may affect COPD outcomes by promoting systemic inflammation. This prospective cohort study aimed to investigate the association between periodontal inflammation and the risk of COPD exacerbations in the Indian population. Methods: A total of 2500 participants with established COPD from various regions of India were enrolled and followed for five years. Baseline assessments included comprehensive periodontal evaluations, with measurements of clinical parameters and inflammatory markers (C-reactive protein, interleukin-6). COPD exacerbations were defined as events requiring medical intervention, such as hospitalization, emergency room visits, or changes in medication. Results: Periodontal inflammation, measured by clinical attachment loss and elevated inflammatory markers, was significantly associated with a higher risk of COPD exacerbations (Hazard Ratio [HR] 2.3, 95% Confidence Interval [CI] 1.7–3.1), even after adjusting for confounders. Specific periodontal parameters and inflammatory markers were identified as strong predictors of future exacerbations. Conclusions: This study provides evidence that periodontal inflammation is an independent and potentially modifiable risk factor for COPD exacerbations in the Indian population. Addressing periodontal health as a part of COPD management may offer a novel approach to reduce the frequency and severity of exacerbations, thereby improving quality of life and clinical outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_1223_24copdexacerbationsindiainflammationperiodontal diseaseprospective cohort study |
| spellingShingle | Anuj Singh Parihar Dhairaysheel N. Edake Sandhya Nema Manoharmayum Laxmipriya Shailja S. Vediya Deepak Kochar Rashmi Laddha Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study Journal of Pharmacy and Bioallied Sciences copd exacerbations india inflammation periodontal disease prospective cohort study |
| title | Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study |
| title_full | Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study |
| title_fullStr | Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study |
| title_full_unstemmed | Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study |
| title_short | Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study |
| title_sort | periodontal inflammation as a modifiable risk factor for copd exacerbations in the indian population a prospective cohort study |
| topic | copd exacerbations india inflammation periodontal disease prospective cohort study |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1223_24 |
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